UROTHELIAL CARCINOMA

This study tests a drug called zanidatamab in about 200 adults with advanced HER2-positive cancers (like breast, stomach, lung, or ovarian cancer) that have worsened after at least one prior treatment. The goal is to see if the drug can shrink tumors and how long that effect last…

This program provides access to an experimental treatment called cretostimogene grenadenorepvec for people with a type of bladder cancer that has not responded to standard therapy. It is for patients with non-muscle invasive bladder cancer that includes carcinoma in situ. The goa…

This study tests a new drug (trastuzumab rezetecan) alone or with an immunotherapy (adebrelimab) in people with advanced bladder cancer that has spread and shows HER2 protein. About 96 adults with HER2-positive urothelial carcinoma will receive the treatment to see if tumors shri…

This study tests a new drug, BMS-986340, alone or with other cancer treatments (nivolumab or docetaxel) in people with advanced solid tumors that have worsened after standard therapy. The goal is to find safe doses and understand side effects. About 949 adults with various cancer…

This study is for people with advanced bladder cancer that has spread and cannot be removed by surgery, and whose tumors have a protein called HER2. It tests a drug called disitamab vedotin, either alone or with pembrolizumab, to see if it can shrink tumors and how safe it is. Ab…

This early-phase study tests a new drug called BL-M07D1 in adults with advanced HER2-positive solid tumors (including breast, lung, stomach, and ovarian cancers) that have not responded to at least two prior treatments. The main goals are to check the drug's safety, find the best…

This study tests a new treatment for people with advanced bladder cancer that has not responded to standard therapies. The treatment uses specially engineered immune cells (CAR-NK cells) from a healthy donor to target and kill cancer cells. Up to 42 adults will receive the cells …

This early-stage trial tests a new drug, AVA6000, designed to deliver chemotherapy directly to tumor cells while reducing harm to healthy tissue. It is for people with advanced solid tumors (like breast, ovarian, or salivary gland cancer) that have not responded to standard treat…

This study tests two experimental drugs, SI-B003 alone or combined with BL-B01D1, in 52 adults with advanced bladder cancer or other solid tumors that have not responded to standard treatments. The goal is to see if these drugs can shrink tumors or slow disease progression. Parti…

This study tests a combination of two drugs (9MW2821 and toripalimab) in people with urothelial cancer, a type of bladder and urinary tract cancer. The goal is to see if the treatment can shrink or control the cancer before and after surgery. About 90 adults with non-spread cance…

This study tests a new drug called BL-B01D1 against standard chemotherapy for people with advanced bladder cancer (urothelial carcinoma) that has worsened after prior treatments. About 508 adults whose cancer did not respond to platinum chemo and immunotherapy will be randomly as…

This study tests an experimental drug called MT-4561 in people with advanced solid tumors (like lung, breast, or pancreatic cancer) who have tried at least one prior therapy. The main goals are to find a safe dose and check for early signs of tumor shrinkage. About 27 adults will…

This study tests whether giving two drugs together after surgery can keep bladder cancer from returning in patients at high risk. About 23 adults who have had their bladder or part of their urinary tract removed will receive sacituzumab govitecan and nivolumab. The goal is to see…

This study tests whether giving two drugs (enfortumab vedotin and pembrolizumab) before bladder cancer surgery can eliminate cancer in the lymph nodes and shrink tumors. About 23 adults with advanced bladder cancer that has spread to lymph nodes will receive the combination befor…

This study tests whether people with advanced bladder cancer can safely switch to a single immunotherapy drug (pembrolizumab) after an initial 24-week combination therapy. The goal is to see if the cancer stays controlled with fewer drugs, reducing side effects. About 30 particip…

This study tests a new medicine, PF-08634404, in adults with advanced bladder cancer that has spread. Some participants get the drug alone, others get it with another cancer drug. The goal is to see if the treatment is safe and shrinks tumors.

This early-phase study tests the safety of an experimental drug (BMS-986504) combined with standard cancer treatments in 60 people whose advanced solid tumors (mesothelioma, stomach/esophageal cancer, or bladder cancer) lack the MTAP gene. The goal is to find a safe dose and see …

This study tests a new drug, ALE.P03, that delivers a cancer-killing agent directly to tumor cells with a specific marker (CLDN1). It is for adults with advanced or metastatic cancers of the cervix, lung, colon, bile duct, or bladder that have not responded to standard treatments…

This early-stage study tests a new drug, enzelkitug, given alone or with standard immunotherapy drugs, in people with advanced solid tumors that have spread or cannot be removed. The main goals are to check safety and find the right dose. About 450 adults with cancers like lung, …

This study tests whether the drug enfortumab vedotin can safely shrink or eliminate high-grade upper urinary tract cancer before surgery. It is for 24 people who cannot take or choose not to take the standard chemotherapy drug cisplatin. Participants will receive the drug before …

This early-phase study is testing an experimental drug called DR-0202 in people with advanced solid tumors (like breast, lung, or pancreatic cancer) that have stopped responding to standard treatments. The main goal is to check the drug's safety and find the right dose. About 96 …

This early-phase study tests an experimental drug called PF-08046876 in adults with advanced solid tumors (bladder, lung, head/neck, esophagus, or pancreatic cancer) that have not responded to standard treatments. The drug is an antibody-drug conjugate designed to stick to cancer…

This study tests a new experimental drug called GI-101, given alone or with other cancer drugs (pembrolizumab or lenvatinib), in people with advanced solid tumors that have spread. The goal is to see if the drug is safe and can shrink or control tumors. About 317 adults with canc…

This study tests whether a combination of two drugs (Talazoparib and Avelumab) can help keep advanced urothelial (bladder) cancer from growing after initial chemotherapy. About 50 adults with cancer that has spread will receive this maintenance treatment. The goal is to see if it…

This study tests an experimental oral drug called NEO212 in adults with certain brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it can slow tumor growth. About 134 participants will receive NEO212 a…

This early-phase study tests a new drug, QXL138AM, for safety and tolerability in about 100 people with advanced solid tumors (like ovarian, pancreatic, or lung cancer) or multiple myeloma. Participants must have tried standard treatments without success. The study will also look…

This early-phase study tests a new experimental drug (LB-LR1109) alone or combined with atezolizumab in people with advanced solid tumors, including lung, head and neck, kidney, bladder, and skin cancers. The main goals are to find safe doses and understand side effects. About 76…

This early-stage study tests a new oral drug, DCC-2812, in about 60 people with advanced kidney, bladder, or prostate cancer that has spread or not responded to other treatments. The main goals are to check safety and find the right dose, while also watching for any tumor shrinka…

This study tests a new version of a cancer drug called UGN-104, given directly into the upper urinary tract, for people with low-grade upper tract urothelial cancer. The goal is to see if it can completely eliminate visible tumors and keep the cancer from coming back. About 70 ad…

This study looks at whether combining radiation and immunotherapy works better than standard chemotherapy for people with high-risk upper urinary tract cancer. The goal is to prevent the cancer from coming back after surgery. About 178 adults with certain high-risk features will …

This early-phase trial tests a new drug called ZM008, alone and with another drug (toripalimab), in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and check for side effects. About 100 adults with canc…

This study is for people with a type of bladder cancer that hasn't spread into the muscle. It tests a drug called durvalumab, either alone or with other treatments like BCG, radiation, or chemotherapy. The goal is to find safe doses and see how well these combinations work at mak…

This early-stage trial tests a new drug, GEN1106, in about 103 people with solid tumors that have not responded to standard treatments. The study has three parts: first, finding a safe dose; then refining that dose; and finally, checking how well the drug works in a specific canc…

This study tests a combination of two targeted drugs (trastuzumab and serplulimab) plus chemotherapy in 20 adults with advanced bile duct or bladder cancers that have stopped responding to standard treatments. The goal is to see if this triple therapy can shrink tumors and improv…

This study looks at whether placing a small tube (stent) in the ureter after bladder removal surgery reduces the risk of urinary tract infections. About 70 adults with bladder or pelvic cancer will be randomly assigned to receive a stent or not. Researchers will track infections …

This study is for people with advanced bladder cancer that has stopped responding to standard immunotherapy. It tests new drug combinations, with or without the drug pembrolizumab, to see if they can shrink tumors or slow the disease. About 48 adults will take part, and the main …

This study tests whether a combination of two chemotherapy drugs, gemcitabine and docetaxel, can treat high-risk bladder cancer that did not respond to standard BCG therapy. About 174 adults will receive the drugs directly into the bladder weekly for 6 weeks, then monthly for up …

This study explores whether a urine DNA test can safely replace many invasive cystoscopies (a scope inserted into the bladder) when checking for bladder cancer. Currently, only 1 in 10 people with blood in their urine actually have cancer, yet nearly all undergo the uncomfortable…

This study is testing whether a combination of blood and urine DNA tests can detect muscle-invasive bladder cancer that standard scopes might miss before bladder removal surgery. About 92 adults scheduled for cystectomy will provide samples to see if the test accurately predicts …

This study is testing a non-invasive urine test called Cxbladder Triage-Plus to see if it can accurately detect bladder cancer in people who have microscopic blood in their urine (invisible to the naked eye). Currently, these patients often need a cystoscopy, an invasive camera p…

This study tests a new radioactive tracer called [68Ga]N188 to see if it can better detect bladder cancer on PET scans. About 20 adults with urothelial carcinoma, including those with advanced or recurrent disease, will receive the tracer and undergo imaging. The goal is to measu…

This study aims to see how well specially trained dogs can detect bladder cancer by smelling urine samples. Researchers will collect urine from 340 adults scheduled for bladder surgery and have the dogs sniff each sample. If successful, this could lead to a simple, non-invasive, …

This study is testing whether a urine test that looks for tumor DNA can find bladder and urinary tract cancers early in people with Lynch syndrome, a genetic condition that raises cancer risk. About 200 participants aged 50–75 will provide urine samples and be followed for one ye…

This study tests whether wearing a compression stocking on one foot during chemotherapy can prevent nerve damage (peripheral neuropathy) caused by certain cancer drugs. About 58 adults with advanced bladder or related cancers will participate, with the left foot covered and the r…

This study tests whether giving the cancer drug nivolumab as a shot at home is as safe and effective as getting it in a clinic. About 50 adults with various cancers will try both settings to see which they prefer and how it affects their quality of life. The goal is to reduce the…

This study tests whether a personalized home exercise program before bladder cancer surgery can improve physical function and recovery. About 128 adults scheduled for bladder or upper tract surgery will either receive the exercise program plus standard care, or standard care alon…

This study tests whether giving cancer treatment at home is preferred over going to a clinic. It involves 27 adults with various cancers in the Florida Panhandle. The goal is to see if home care improves patient satisfaction and is safe.

This study looks at two different treatment plans for people aged 65 and older with advanced bladder cancer who cannot take the standard chemotherapy drug cisplatin. The goal is to see which treatment better maintains quality of life and causes fewer side effects. Participants wi…

This study is testing whether a simple urine test every 6 months for 2 years can help find bladder cancer at an earlier stage in people at high risk. Participants must be 50 or older with a heavy smoking history or long-term exposure to certain workplace chemicals. The goal is to…

This study is testing whether an artificial intelligence tool can help match cancer patients to clinical trials they might be eligible for. Researchers will enroll up to 50,000 people with various types of cancer and use the AI to suggest trials. The goal is to see if this approa…

This study looks at how hospitals handle patients who are admitted with blood in their urine (hematuria). Researchers will track about 1,050 adults to see differences in care, how long they stay, and what happens after. The goal is to create better guidelines and improve the pati…

This study is a registry that collects information from about 1,930 people with advanced kidney or bladder cancer in Germany. Researchers will track what treatments patients receive, how their disease responds, and their quality of life over time. The goal is to understand real-w…

This study looks at whether removing lymph nodes during surgery for upper tract urothelial cancer helps prevent the cancer from coming back. About 94 adults with this cancer will be randomly assigned to have standard surgery with or without lymph node removal. Researchers will tr…

This study is for people with certain advanced cancers (like lung, head and neck, or esophageal cancer) who are already receiving immunotherapy. Researchers want to see if adding radiation therapy improves outcomes and, more importantly, if changes in immune cells in the blood ca…

This study looks at how a drug called enfortumab vedotin affects the nerves of people with advanced bladder cancer that has spread. Researchers will measure nerve function with simple tests before and during treatment. The goal is to better understand nerve damage caused by the d…

This study is collecting tumor, blood, urine, and stool samples from 1000 adults with suspected or diagnosed bladder cancer. The samples will be stored for future research to better understand the disease. No treatment or direct benefit is offered to participants.

This study looks at 300 women aged 50 and older who have blood in their urine along with a bladder infection. Researchers want to see if these women need the full set of cancer tests (like a camera in the bladder and CT scans) or if they can safely skip them. The goal is to find …

This study looks at how kidney and bladder cancers use nutrients like sugar and fat to grow. About 600 adults having surgery or a biopsy will receive a special nutrient tracer through an IV. Blood and tissue samples are then analyzed to see how the cancer uses these fuels. Partic…