SYSTEMIC SCLEROSIS

This early-stage study tests a one-time treatment made from donor immune cells that are gene-edited to target and destroy faulty immune cells causing disease. It is for 80 adults with severe lupus, scleroderma, or myositis that have not responded to standard therapies. The main g…

This early-stage study tests a new treatment using a patient's own immune cells, modified to target and destroy faulty immune cells causing autoimmune diseases like lupus and scleroderma. The goal is to see if this 'reset' is safe and can control disease activity. About 20 adults…

This study tests whether injecting a patient's own cultured stem cells into the base of finger ulcers can help them heal. It is for people with scleroderma who have painful, open sores on their fingers that have not improved with other treatments. The trial will compare the stem …

This study tests a drug called nemolizumab in adults with systemic sclerosis, a disease that causes skin thickening and organ damage. The goal is to see if the drug can reduce skin hardness and find the best dose. About 162 participants will receive either nemolizumab or a placeb…

This study tests a new treatment called anti-CD19/BCMA universal CAR-T cells for people with severe autoimmune diseases like lupus, scleroderma, and rheumatoid arthritis that haven't responded to standard therapies. The treatment uses specially engineered immune cells to target a…

This study tests a new treatment for people with lupus, scleroderma, or certain muscle diseases. The treatment uses a patient's own immune cells, modified to find and attack faulty B cells that drive the disease. About 24 adults will receive the therapy after a short course of ch…

This phase 3 study tests whether a one-time infusion of specially engineered immune cells (CAR T cells) can control active systemic sclerosis better than current standard treatments. About 92 adults with lung and skin involvement will be randomly assigned to receive either the ce…

This early-phase study tests a new treatment called RD06-05, which uses a patient's own immune cells modified to target and calm overactive immune responses in autoimmune diseases like lupus, scleroderma, and multiple sclerosis. The main goal is to check safety and how the body h…

This early-stage trial tests a new treatment called AZD0120, which uses a patient's own immune cells modified to target and calm overactive immune responses. It is for adults with systemic sclerosis, inflammatory myopathies, or difficult-to-treat rheumatoid arthritis. The main go…

This early-stage trial tests whether injecting donated stem cells into the muscles around finger ulcers can help heal them in people with scleroderma. The study includes 20 adults with at least one painful, deep finger sore that did not improve with standard treatment. The main g…

This study tests a new treatment called NKX019, made from immune cells (natural killer cells) that are engineered to target and destroy certain immune cells causing disease. It is for people with autoimmune conditions like systemic sclerosis, inflammatory myopathies, or vasculiti…

This early-stage study tests a new treatment called ALLO-329 for people with lupus, myositis, or scleroderma. The therapy uses specially engineered immune cells from a healthy donor to target and calm overactive immune cells. The main goal is to check safety and find the right do…

This study tests a new treatment called CABA-201 for people with systemic sclerosis (scleroderma), a disease that causes hardening of the skin and can damage organs. The treatment uses a patient's own immune cells, modified to target and destroy certain immune cells that drive th…

This study tests whether adding two immune-targeting drugs (belimumab and rituximab) to standard treatment can improve skin hardening in people with early, severe scleroderma. About 30 adults will receive either the drug combo or a placebo, plus their usual medication, for one ye…

This study tests a new treatment using a patient's own immune cells, modified to attack harmful cells in three severe autoimmune diseases: lupus kidney disease, scleroderma, and Sjogren's syndrome with lung complications. About 45 adults will receive a single infusion of CD19-BCM…

This early-stage study tests a new cell therapy called YTS109 in 18 adults with autoimmune diseases like lupus and Sjogren's syndrome that have not responded to standard treatments. Participants receive a single infusion of these immune cells to see if it is safe and can help con…

This early-phase trial is testing a new treatment made from donated cord blood cells, engineered to target and destroy faulty immune cells. It is for people with severe lupus kidney disease, systemic sclerosis, or Sjogren's syndrome with lung complications. The main goal is to se…

This study tests a stem cell transplant in children and young adults (ages 8 to 25) with life-threatening lupus or scleroderma that hasn't responded to standard treatments. The goal is to wipe out the faulty immune system and replace it with the patient's own healthy stem cells, …

This study tests a new treatment for autoimmune diseases like lupus and scleroderma. It combines a special immune cell therapy (AD-PluReceptor NK cells) with a targeted drug (tafasitamab) and chemotherapy. The goal is to find a safe dose and see if it can control the disease. Abo…

This study tests whether combining two drugs (nintedanib and tocilizumab) works better than standard treatments for lung scarring caused by scleroderma. About 86 adults will take the combination or standard therapy for 56 weeks. The main goal is to see if the combo better preserv…

This study tests if itacitinib is safe and effective for adults with systemic sclerosis, a disease that causes skin thickening and organ damage. About 74 participants will receive the drug or a placebo for a year, and doctors will measure changes in skin thickness. The goal is to…

This early-phase study tests a new treatment called CC-97540, which uses a person's own immune cells (CAR T cells) to target and calm the overactive immune system in severe autoimmune diseases like lupus, myositis, scleroderma, and rheumatoid arthritis. The goal is to see if it i…

This study tests a stem cell transplant for people aged 8-24 with severe systemic sclerosis (scleroderma) that hasn't improved with standard treatments. The goal is to see if this approach is safer and still controls the disease. Participants receive high-dose therapy to reset th…

This study is building a large collection of health information and blood samples from 5,000 adults with rheumatic diseases like rheumatoid arthritis, lupus, and scleroderma. Researchers will use this data to find links between patient outcomes and biological markers. The goal is…

This study follows 500 adults with systemic sclerosis (scleroderma) for up to 5 years. Researchers will track how the disease naturally progresses by monitoring key complications like lung and kidney problems. They will also collect blood and tissue samples to better understand t…

This study aims to better understand systemic sclerosis, a rare disease that causes skin hardening and organ damage. Researchers will analyze skin and blood samples from 40 adults with the condition to see how different cell types interact. The goal is to find new clues for futur…

This study looks at the gut bacteria of 60 people with systemic sclerosis (a chronic autoimmune disease) and compares them to healthy volunteers. Researchers will collect stool samples over 7 months from patients to see how their gut bacteria change over time. The goal is to find…