SYSTEMIC SCLEROSIS

This study tested whether using a stem cell transplant early in the disease is better than starting with standard immunosuppressive drugs for people with a severe form of scleroderma. Sixty adults with early diffuse scleroderma were randomly assigned to either receive their own s…

This study tested whether adding a strong immune-suppressing drug (cyclophosphamide) to standard prednisone can stop lung function from getting worse in people with scleroderma-related lung scarring. Forty adults with worsening lung function took part. The goal was to see if more…

This early study tested a drug called nemolizumab in 6 people with systemic sclerosis, a rare disease that causes skin to harden and tighten. The main goal was to see if the drug could reduce skin thickness over 24 weeks, and to check for side effects. Researchers also looked at …

This study looked at whether a chest ultrasound can find early signs of lung disease in people with systemic scleroderma, a condition that often leads to deadly lung scarring. Current methods like CT scans have limits, so researchers tested ultrasound in 30 patients without known…

This study tested an online self-management program for people with scleroderma, a chronic autoimmune disease. The program includes educational videos and group video calls led by trained peers. It aims to help patients feel more confident managing their symptoms like pain, fatig…

This study tested whether a personalized home respiratory rehabilitation program is feasible for people with systemic sclerosis (scleroderma) who have early lung disease. Fifteen participants did one supervised session and then followed a 3-month home exercise plan. The goal was …

This study tested whether rituximab, a drug used for certain cancers and autoimmune diseases, can reduce joint pain and swelling in people with scleroderma (systemic sclerosis) who have arthritis. 22 adults with active joint inflammation took part. Researchers counted tender and …

This study involved 113 adults with systemic sclerosis (scleroderma) to develop a standard way to measure how the disease affects their daily life and functioning. Researchers worked with patients and experts to create a list of important items. The goal is to improve how doctors…

This study looked at whether a type of white blood cell called eosinophils plays a role in the scarring (fibrosis) seen in systemic sclerosis, an autoimmune disease. Researchers compared blood and tissue samples from 40 patients with systemic sclerosis and 30 healthy volunteers. …

This study looked at the experiences of family members who care for someone with systemic sclerosis, a rare and serious disease. Researchers surveyed 50 caregivers to understand their physical, mental, and social challenges. The goal is to use this information to create better su…

This study tested a smartphone app called RENEW designed to help people with scleroderma manage fatigue and build resilience. Researchers enrolled 43 participants to see if the app was easy to use and if people would stick with it. The goal was to gather information on how well t…

This study followed 56 people with systemic sclerosis (scleroderma) who also have a serious lung condition called diffuse infiltrating pneumonia. Researchers measured lung function at 12 and 24 months to see how it changed and to identify factors that might predict worsening. The…

This study looked at 214 people with systemic sclerosis (scleroderma) to find out how often calcium deposits form under the skin, especially in the hands and feet. Researchers used X-rays to detect these deposits and checked if they were linked to damage in organs like the lungs,…

This study looked at 629 adults with different types of pulmonary arterial hypertension (PAH), including those linked to HIV, heart defects, and connective tissue diseases. Researchers tested blood for antibodies that attack blood vessel and lung cells to see if these immune mark…