SYSTEMIC SCLEROSIS

This study tests a new treatment called CD19 UCAR-T cells for people with autoimmune diseases like lupus, vasculitis, and Sjögren's syndrome. The goal is to see if it is safe and can control the disease. About 24 adults aged 18 to 65 will take part. The treatment uses modified im…

This study tests a new oral medication, nerandomilast, for people with systemic sclerosis, a chronic autoimmune disease that causes skin thickening and organ damage. About 448 adults will be randomly assigned to receive either the drug or a placebo twice daily for up to 4 years. …

This study aims to understand sleep breathing problems in people with systemic sclerosis (scleroderma), a condition that causes skin and organ hardening. Researchers will use overnight sleep tests (polysomnography) to measure breathing pauses in 30 adults with scleroderma. The go…

This study looks at whether a substance in the blood called catestatin can be used as a marker for disease activity in people with systemic sclerosis (scleroderma). Researchers will compare catestatin levels in 70 patients with the disease to healthy volunteers. The goal is to se…

This study compares two ways of sharing research results with people who have scleroderma, a rare autoimmune disease. About 128 participants will receive either an infographic or a plain-language summary and rate them for completeness, understandability, and ease of use. The goal…

This study is creating a large collection of medical data and blood samples from 450 adults with autoimmune diseases (rheumatoid arthritis, lupus, or scleroderma) and 50 healthy volunteers. Researchers will use advanced lab techniques to find biological patterns that distinguish …