RESPIRATORY FAILURE

This study compares two methods doctors use to help patients breathe during a cardiac arrest in the hospital: a supraglottic airway (a tube placed above the voice box) versus endotracheal intubation (a tube placed into the windpipe). About 1,060 adults who suffer cardiac arrest w…

This study looks at whether using a heart-lung machine (ECMO) routinely during lung transplants is better than using it only when necessary. About 218 people getting a lung transplant will take part. The goal is to find out which approach reduces time in the ICU and improves reco…

This study compares standard mechanical ventilation to a personalized, lung-stress oriented strategy in 1,100 adults with acute respiratory distress syndrome (ARDS). The goal is to see if tailoring the breathing machine settings to each patient can improve survival. Participants …

This study compares three ways to help people with severe low oxygen levels breathe easier: a helmet that pushes air, a CPAP mask, and high-flow oxygen through the nose. The goal is to see which method reduces the need for a breathing tube. About 1,200 adults with acute respirato…

This study tests whether using a real-time lung imaging tool called electrical impedance tomography (EIT) to guide breathing therapy can help adults who have been on a breathing machine for 21 days or more get off it faster. About 200 participants will either receive standard the…

This study looks at whether using a high-flow nasal cannula along with noninvasive ventilation helps people with acute respiratory failure breathe better than noninvasive ventilation alone. It will include 75 adults in the ICU. The main goal is to see if oxygen levels in the bloo…

This study looks at whether playing music for children in the intensive care unit can help them stay calm and stable while their breathing tube is removed. The process can be stressful and painful, sometimes leading to complications. Researchers will compare children who receive …

This study looks at two ways to help heart failure patients breathe after a breathing tube is removed. It compares high-flow nasal cannula (a device that delivers warm, moist oxygen through the nose) with noninvasive ventilation (a mask that helps push air into the lungs). The go…

This study tests whether a community-based exercise program can improve exercise capacity in 200 adults aged 18-85 with reduced heart or lung function. Participants will do 40-60 minutes of exercise (like brisk walking or cycling) five times a week for eight weeks. Researchers wi…

This study looks at two sedatives, ciprofol and propofol, for ICU patients who need help breathing but are not on a ventilator. The goal is to see which drug works better and has fewer side effects like breathing problems. About 1,680 adults from 30 hospitals in China will be inc…

This study compares two methods (pressure support ventilation and T-piece) used to test if overweight ICU patients are ready to have their breathing tube removed. About 100 adults with a BMI of 25 or higher who have been on a ventilator for over 24 hours will be randomly assigned…

This study tests a non-invasive light and magnetic field therapy (PBMT-sMF) in 112 adults on mechanical ventilators. The goal is to see if it reduces ICU stay and prevents diaphragm muscle weakening. Participants receive either active therapy or a placebo, alongside standard care…

This study looks at how different types of blood platelets change in adults who need ECMO support for severe heart or lung failure. Researchers will take blood samples on days 1, 3, and 7 after ECMO starts to measure shifts in platelet populations. The goal is to better understan…

This study is for adults with ARDS (a severe lung condition) who are on a breathing machine and need to lie on their stomach to help their lungs work better. Researchers will use a special 3D imaging technique called EIT to watch how air and blood flow change in different parts o…

This study tests whether a training program for hospital staff can improve how oxygen levels are managed in ICU patients on breathing machines. The goal is to keep oxygen saturation between 90-96% and reduce the time patients need a ventilator. About 3,600 adults in the ICU who n…

This study collects blood and tissue samples from 100 adults who have had a lung transplant in the last 10 years. Researchers will use these samples to study biomarkers and how infections affect outcomes. The goal is to improve care for people with advanced lung disease, not to t…

This study looks back at medical records of about 60 ICU patients who received a treatment called low-flow ECCO2R, which helps remove carbon dioxide from the blood when the lungs are failing. Researchers want to describe how the therapy is used in practice and what outcomes patie…

This study tests whether artificial intelligence can help emergency call operators quickly identify serious conditions like heart attack, stroke, or breathing trouble. Researchers will analyze millions of past emergency calls to build and compare AI models. The goal is to reduce …

This study looks at whether using an EEG (a device that tracks brain activity) can give a more accurate picture of sleep quality in intensive care patients with acute respiratory failure. About 47 adults will have their sleep assessed by both EEG and nurse observation. The goal i…

This study follows 100 adults who needed a machine called ECMO to support their heart and lungs after a severe failure. Researchers want to understand how muscle wasting and weakness affect patients' recovery and quality of life. The goal is to find better ways to help people reg…

This study looks at whether a special ultrasound technique can help doctors choose the right oxygen flow for people with breathing failure. Researchers will measure how the diaphragm (the main breathing muscle) works in 100 healthy adults and patients. The goal is to see if this …

This study is developing a new scoring system called REXs to help doctors decide when ICU patients on breathing machines are ready to have their breathing tube removed. The goal is to reduce the number of patients who need the tube put back in within 48 hours. About 470 adults in…

This study looks at how a new FDA-approved suction device affects heart rate and oxygen levels in intubated preterm and term babies compared to standard suctioning. About 30 infants in the NICU will be monitored during both procedures. The goal is to see if the new device causes …

This study tests whether a supraglottic airway (a small mask placed over the voice box) can be used as the main tool to help premature babies breathe during delivery room resuscitation. About 20 infants born between 29 and 33 weeks who need breathing support at birth will receive…

This study looks at how changing the pressure in a breathing machine (ventilator) affects the effort patients need to breathe on their own. It will include 12 adults in the ICU who are already using a ventilator to help them breathe. Researchers will test four different pressure …

This study looks at how the oxygen level target and the type of oximeter used together affect the amount of oxygen patients need. It includes 40 adults in the cardiac surgery ICU who are either breathing on their own or on a ventilator. The goal is to see if using a higher oxygen…

This study looks at a new way to set breathing machine pressure for people with obesity who need a ventilator. It involves 30 patients with a BMI of 30 or higher. The goal is to see if this method is practical and safe enough to test in a larger study.

This study looks at how the diaphragm—the main breathing muscle—weakens in patients on a breathing machine (mechanical ventilation) in the ICU. Researchers will use mild nerve stimulation and ultrasound to measure muscle strength and brain control over time. The goal is to unders…