Respiratory failure

This trial tests whether epidural spinal cord stimulation can help people with severe brain injury breathe without a ventilator. Ten patients with stroke or traumatic brain injury who need mechanical ventilation will receive a surgically implanted electrode that delivers electric…

This study compares a new type of breathing device (biphasic cuirass ventilator) to standard non-invasive ventilation in 50 high-risk patients who are about to have their breathing tube removed. The goal is to see if the new device can reduce the number of patients who need to be…

Blunt chest trauma can lead to serious breathing problems, but current imaging tools have limits. This study tests whether adding a diaphragm ultrasound to the standard lung ultrasound helps doctors predict which patients will develop hypoxemic respiratory failure. Adults with is…

This study looks at whether adding a type of stretching called proprioceptive neuromuscular facilitation (PNF) to standard breathing exercises helps patients get off a breathing machine faster. About 93 adults in the ICU who are stable and awake will be split into three groups: o…

This study tests a redesigned non-invasive ventilation mask that may help people with respiratory insufficiency breathe more easily. Sixty adults who are stable on NIV will wear their usual mask for one hour and then the new mask for one hour. Researchers will measure breathing r…

This study tests a procedure that freezes the nerves around broken ribs to see if it reduces pain and helps people breathe better. About 30 adults with at least two broken ribs and severe pain will either get the freezing treatment or standard pain medicine. Researchers will trac…

This study tests two methods to train the breathing muscles of patients with respiratory failure who are on mechanical ventilators. One method slowly increases the effort needed to trigger a breath, while the other gradually reduces the machine's support. The goal is to see which…

This study looks at elderly patients (60 and older) with COPD who need a breathing machine in the ICU. Researchers will check their nutritional status and measure the thickness of their diaphragm muscle using ultrasound. The goal is to see if these factors can predict how well pa…

This pilot study investigates how standard changes to mechanical ventilator settings—such as breath size, flow rate, and pressure—affect shortness of breath in awake patients on ventilators. Many ICU patients experience breathlessness despite sedation, which may contribute to PTS…

This study looks at whether a bedside lung ultrasound can help doctors see how well the lungs of obese patients are opening during a breathing machine procedure. The goal is to find the best air pressure to keep lungs open and improve oxygen levels. About 45 adults with a BMI of …

This study looks at whether a chest CT scan gives important new information beyond a simple chest X-ray for ICU patients with respiratory failure. Researchers will review records of 50 patients to see if CT findings changed their treatment. The goal is to find out if some CT scan…

This study looks at patients who needed a breathing machine for more than 48 hours in the ICU between 2021 and 2023. Researchers will interview 90 adults in 2025 to see if they still have physical, mental, or thinking problems (called post-ICU syndrome) and how it affects their q…