RESPIRATORY FAILURE

This study looks at 100 adults on ECMO (a machine that helps breathe) for respiratory failure. It compares a standard blood thinner given through a vein to one given as a shot under the skin. The goal is to see if the shot is as safe and effective at preventing clots and bleeding…

This study tests a simple checklist called CMOT to help ICU teams reduce distress when removing breathing machines from dying patients. About 184 patients and their care teams will take part across four ICUs. The goal is to see if the checklist is practical and improves comfort d…

This study tests whether an inhaled asthma medicine (salbutamol) can safely reduce breathing problems in newborns with transient tachypnoea, a condition where fluid stays in the lungs after birth. About 608 babies born between 32 and 42 weeks are taking part. The goal is to see i…

This study was designed to measure pressure inside the lungs of people with severe obesity using a small balloon in the esophagus and a CT scan. It aimed to compare these measurements between people with a BMI over 40 and those with a normal BMI. The study was withdrawn before en…

This study looks at whether the type of breathing machine setting used in the ICU affects how well patients recover. Researchers will switch the ventilator mode used in entire ICUs every two months and track survival and time off the machine. About 4,785 adults on breathing machi…

This study looks at whether moving from lying flat to sitting upright improves oxygen levels in patients with respiratory failure who are on a breathing machine. Researchers will measure oxygen and carbon dioxide in the blood to see if position makes a difference. The study invol…

This quality improvement study tests a software system that gives ICU teams real-time feedback on ventilator settings and patient data. The goal is to reduce ventilator-associated events and lung injury in 875 patients on breathing machines. Researchers will compare outcomes befo…

This study follows 500 adults who were in the ICU with breathing failure. Researchers want to see if COVID-19 patients have different long-term mental and physical problems compared to those without COVID-19. The goal is to understand these differences so doctors can better treat…