POST-OPERATIVE PAIN

This study looked at 63 adults who had heart surgery through a small cut in the chest. It compared two pain relief methods: freezing the nerves (cryoanalgesia) and a nerve block (BRILMA). The goal was to see which method better reduces pain after surgery, including where and how …

This study tested different ways of shaping the root canal during treatment to see which causes the least pain afterward. 168 adults with asymptomatic apical periodontitis (a silent infection at the tooth root) were treated using either a single file or a combination of files. Pa…

This study looked at two methods to control pain after a mastectomy: a nerve block (erector spinae plane block) and numbing medicine injected into the wound. 37 women took part, and researchers measured how much morphine they needed in the first day after surgery. The goal was to…

This study looked at whether a genetic test can help doctors choose the best pain medicine for women after gynecologic surgery. 112 women were randomly assigned to have their painkiller choice guided by a genetic test or to receive standard care. The goal was to see if using gene…

This study tested a new medicine called MR-107A-02 to see if it can safely reduce pain after hernia repair surgery. About 579 adults took part, comparing the new drug to a placebo (fake pill) and an active painkiller. The goal was to measure pain intensity and the need for extra …

This study tested two methods of giving a nerve block (erector spinae plane block) to manage pain after lumbar spinal fusion surgery. 52 adults received either an ultrasound-guided or a surgeon-placed block using a mix of numbing medicine and dexmedetomidine. The goal was to see …

This study tested whether adding magnesium to a common numbing medicine (bupivacaine) improves pain control after total knee replacement. 94 adults having knee surgery received either the combination or bupivacaine alone. The goal was to see if the mix reduces pain scores and the…

This study tested whether adding dexamethasone or magnesium sulfate to a standard numbing medicine (bupivacaine) could provide longer pain relief after total hip replacement. 66 adults received an ultrasound-guided nerve block before surgery. The main goal was to see how long it …

This study tested if applying cold therapy (cryotherapy) after a root canal can lower pain and inflammation in people with an infected tooth. Thirty adults with a painful lower premolar were split into three groups: one got an ice pack on the cheek, one got a cold saline rinse in…

This study tested whether using a laser or different sonic cleaning tools during a root canal could lower pain after the procedure. Eighty adults with infected single-root teeth were split into four groups, each receiving a different cleaning method. Patients reported their pain …

This study tested two different ultrasound-guided nerve blocks to see which one provides better pain relief after inguinal hernia repair. Forty-three men undergoing hernia surgery received one of the two blocks, and their pain was measured using a simple 0-to-10 scale. The goal w…

This study looked at whether a quadratus lumborum (QL) nerve block can reduce pain and the need for opioid painkillers after robotic surgery for pelvic organ prolapse. Seventy women were randomly assigned to receive either standard enhanced recovery care or a QL block. The main g…

This study looked at whether using a sonic device to clean the tooth during a root canal can lower pain afterward. Fifty-eight adults with infected teeth were randomly assigned to get either the sonic cleaning or the usual syringe method. Their pain was measured before and at sev…

This study tested whether adding dexamethasone (a steroid) to a standard nerve block could provide longer pain relief after total knee replacement surgery. 66 adults having knee replacement under spinal anesthesia received either the nerve block with or without dexamethasone. The…

This study looked at 60 adults aged 18-65 having partial hip replacement to compare two spinal anesthesia methods: hypobaric (light) and hyperbaric (heavy). The goal was to see which method better protects blood pressure and reduces pain after surgery. Researchers measured pain l…

This study tested a new approach for knee replacement surgery in 70 people with severe knee arthritis. The idea was to add a nerve-freezing procedure during the operation to see if it reduces pain and helps the knee work better after surgery. The study compared people who got the…

This study tested three different oral painkillers to see which one works best for pain after a root canal. One hundred adults with tooth pain took part. The goal was to find the most effective way to ease discomfort after the procedure.

This study tested an experimental drug called CPL-01 to see if it can control pain after open inguinal hernia surgery. About 518 adults received either CPL-01, a standard painkiller, or a placebo. The main goal was to measure how much pain people felt during activity using a 0-to…

This study tested two methods of pain control after radical cystectomy (bladder removal) surgery. Twenty adults received either a standard epidural or a newer ultrasound-guided nerve block (erector spinae plane block). Researchers measured how long pain relief lasted, pain scores…

This study looked at 105 older adults (over 60) having hip fracture surgery to see if continuous spinal anesthesia (a tube that delivers numbing medicine over time) works better than a single shot of spinal anesthesia or general anesthesia for pain control. The researchers measur…

This study looked at 80 women having breast reduction surgery to see which nerve block—erector spinae plane block or serratus anterior plane block—works better for pain after surgery. The goal was to reduce pain and the need for strong painkillers like opioids. Researchers measur…

This study tested whether adding dexmedetomidine to a standard numbing medicine (bupivacaine) in chest nerve blocks can provide better pain relief after heart surgery. Sixty adults having open-heart surgery through a breastbone incision took part. The main goal was to see how lon…

This study tested a pain-relief method for adults having open-heart surgery. Half received a numbing medicine (ropivacaine) through small tubes placed near the breastbone, while the other half got a saltwater placebo. The goal was to see if the nerve block could lower the amount …

This study tested two different nerve blocks to see which one works better for pain after laparoscopic inguinal hernia surgery. 90 adults received either a modified thoracoabdominal nerve block (M-TAPA) or a standard transversus abdominis plane (TAP) block. Researchers measured p…

This study tested three different pain-relief methods for people having lung surgery through a single small cut. 102 adults were randomly assigned to receive one of the blocks. The goal was to see which method kept patients comfortable the longest after surgery.

This study looked at whether the 4-7-8 breathing technique (breathe in for 4 seconds, hold for 7, out for 8) can help reduce pain, nausea, and vomiting after bariatric surgery. Sixty adults who had weight-loss surgery were split into two groups: one practiced the breathing techni…

This study tested whether a non-opioid painkiller called suzetrigine can help adults control pain and avoid opioids after outpatient facial plastic surgery. 100 adults took the drug as part of their standard pain plan. Researchers tracked how many opioid pills they used and wheth…

This study tested a new medicine called MR-107A-02 to see if it can safely relieve pain after bunionectomy (foot surgery). About 410 adults took part. The goal was to measure how well the drug reduces pain and whether it can cut down the need for stronger opioid painkillers.

This study tested two different nerve blocks to manage pain after midshaft clavicle (collarbone) surgery in 50 adults. One block targets the shoulder area, the other the chest wall. Researchers measured how long pain relief lasted and whether one method caused less diaphragm weak…

This study looked at whether giving ketamine during surgery and methadone after surgery can prevent a condition called opioid-induced hyperalgesia, where painkillers actually make you more sensitive to pain. 113 adults having open colorectal surgery took part. The goal was to see…

This study tested whether a single injection of F14 (a long-acting pain reliever) given during knee replacement surgery can reduce pain and the need for opioid painkillers afterward. 151 adults aged 45 to 80 who had a knee replaced took part. The goal was to see if F14 plus stand…

This study tested whether multi-port epidural catheters provide better pain relief than single-port catheters after chest or upper belly surgery. 240 adults took part. The main goal was to see if the multi-port catheter reduced the need for extra pain medicine or catheter replace…

This study tested three different nerve blocks to see which one works best for pain after shoulder surgery. Forty adults having shoulder surgery received one of the blocks, and their pain was measured using a simple 0-to-100 scale. The goal was to find a block that controls pain …