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New pain shot could help knee replacement patients recover faster

NCT ID NCT05603832

First seen Jan 04, 2026 · Last updated May 15, 2026 · Updated 15 times

Summary

This study tested whether a single injection of F14 (a long-acting pain reliever) given during knee replacement surgery can reduce pain and the need for opioid painkillers afterward. 151 adults aged 45 to 80 who had a knee replaced took part. The goal was to see if F14 plus standard pain care works better than standard care alone.

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Contacts and locations

Locations

  • CenExel JBR

    Salt Lake City, Utah, 84107, United States

  • Endeavor Clinical Trials

    San Antonio, Texas, 78240, United States

  • HD Research - First Surgical Hospital

    Bellaire, Texas, 77401, United States

  • HD Research - Legent Orthopedic Hospital

    Carrollton, Texas, 75006, United States

  • Phoenix Clinical Research

    Tamarac, Florida, 33321, United States

  • The Orthopedic Center

    Tulsa, Oklahoma, 74104, United States

  • Woodland International Research Group

    Little Rock, Arkansas, 72211, United States

Conditions

Explore the condition pages connected to this study.