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Magnesium boost for knee surgery pain relief?

NCT ID NCT06520475

Symptom relief Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding magnesium to the anesthetic bupivacaine for a nerve block around the knee provides better pain relief after total knee replacement surgery. 94 adults undergoing knee replacement were randomly assigned to receive either bupivacaine with magnesium or bupivacaine alone. The goal was to see if the combination reduces pain scores, delays the first request for additional pain medication, and lowers opioid use.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bupivacaine and magnesium sulfate
What this could lead to
If adding magnesium works better than bupivacaine alone, it could offer longer-lasting pain relief after knee replacement surgery and reduce the need for strong painkillers.
What could go wrong
This is a small, completed study with only 94 participants. The results may not apply to all patients, and magnesium could cause side effects like low blood pressure or muscle weakness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

94 people

The number who actually took part.

Started

Aug 2024

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * American Society of Anesthesiologist (ASA) I or II physical status. * Between 18 and 70 years of age. * Both genders. * Patients undergoing total knee replacement surgery. Exclusion Criteria: * Patient refusal. * ASA Ⅲ and Ⅳ patients. * Known allergy to the study drugs. * Hypermagnesemia. * Central or peripheral neurological disease. * Pregnancy. * Drug or alcohol abuse. * Localized infection at the site of the block. * Bleeding disorder (platelets count less than 100,000 or international normalized ratio more than 1.4)

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Post operative pain

Contacts and locations

Locations

  • Kasr Alaini hospital

    Cairo, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.