METASTATIC MALIGNANT SOLID NEOPLASM

This early-phase trial tests a combination of three drugs (copanlisib, olaparib, and durvalumab) in people with advanced solid tumors that have spread or cannot be removed by surgery. The goal is to find the safest dose and see if the drugs shrink tumors. About 39 adults with spe…

This early-phase trial tests the safety and best dose of combining two drugs—ziv-aflibercept and pembrolizumab—in people with advanced solid tumors that have spread. Ziv-aflibercept cuts off the tumor's blood supply, while pembrolizumab helps the immune system fight cancer. The s…

This early-phase trial tests the safety and best dose of two oral drugs, ZEN003694 and binimetinib, taken together. It is for people with advanced solid tumors that have RAS pathway changes or triple-negative breast cancer that has spread or cannot be removed by surgery. The stud…

This early-phase trial tests a combination of two drugs—trastuzumab deruxtecan (a targeted chemotherapy) and ceralasertib (which blocks a DNA repair enzyme)—in people with advanced solid tumors that have a HER2 mutation. The goal is to find the safest dose and see if the combo wo…

This early-phase trial tests the safety and best dose of combining two drugs—neratinib and trastuzumab deruxtecan—for people with advanced solid tumors that have HER2 gene changes and have spread or can't be surgically removed. The goal is to see if the combination can shrink tum…

This study tests whether the immunotherapy drug nivolumab can help control advanced solid tumors that have spread or cannot be removed by surgery. It includes 16 adults whose tumors have a specific genetic change (ARID1A mutation) and a protein marker (CXCL13). The goal is to see…

This early-phase study tests the safety and best dose of two drugs, ceritinib and everolimus, given together to adults with advanced solid tumors or a specific type of lung cancer (ALK-positive NSCLC). The goal is to find a dose that controls tumor growth with manageable side eff…

This early-phase trial tests a new drug (DS3201) combined with an immunotherapy (ipilimumab) in people with advanced prostate, bladder, or kidney cancer that has spread. The goal is to find the safest dose and see if the combination can help control the cancer. About 65 adults wi…

This study tests whether adding nilotinib to paclitaxel can help control solid tumors that have continued to grow after prior taxane therapy. About 40 adults with advanced or worsening cancers will receive the combination. The goal is to see if the drugs work together to slow tum…

This study tests a drug called pembrolizumab (Keytruda) in 157 people with rare cancers that have spread or cannot be removed. The drug helps the immune system fight cancer by blocking a protein that tumors use to hide. The main goal is to see if the drug can stop the cancer from…

This early-phase study tests the safety and best dose of the drug veliparib when given with standard chemotherapy (carboplatin and paclitaxel) in adults with advanced solid tumors that also have liver or kidney dysfunction. The goal is to find out how the body processes the drugs…

This early-stage trial tested two drugs, adavosertib and olaparib, given one after the other in 13 people with advanced solid tumors that have specific genetic mutations. The goal was to find the best dose and check for side effects. The approach aims to shrink or stabilize tumor…

This early-phase trial tests the safety and best dose of sonidegib combined with the immunotherapy pembrolizumab in people with advanced solid tumors that have spread. The goal is to see if this drug pair can shrink tumors or slow their growth. About 36 adults with cancers like m…

This study is for people with advanced solid tumors that have specific gene changes (KRAS or NRAS mutations) and have not responded to standard treatments. It tests two drugs: trametinib, which blocks a protein that helps cancer grow, and navitoclax, which blocks proteins that ke…

This early-stage trial tests a combination of three drugs—ZEN003694, nivolumab, and ipilimumab—in people with advanced solid tumors that have stopped responding to standard treatments. The goal is to find the safest dose and see if the combo can shrink or stabilize tumors. About …

This study tests a drug called adavosertib in 18 adults with advanced solid tumors that lack the SETD2 gene. The drug works by blocking enzymes that help cancer cells grow. Researchers want to see if it can shrink tumors or keep them stable for at least 6 months.

This study tests whether adding panitumumab to sotorasib works better than sotorasib alone for people with advanced solid tumors that have a specific KRAS G12C mutation. About 105 adults will take part. The goal is to see if the combination can slow tumor growth or shrink tumors.

This early-phase study tests a new drug (M6620) combined with a standard chemotherapy (irinotecan) in adults with advanced solid tumors that have spread or can't be removed by surgery. The main goal is to find the safest dose and check for side effects. About 66 participants with…

This study tests a combination of two drugs (peposertib and avelumab) plus a special type of radiation for people with advanced solid tumors or bile duct cancers that have spread. The goal is to find the best dose and see if the treatment can shrink tumors or stop them from growi…

This early-phase study tests the safety and best dose of the drug neratinib combined with everolimus, palbociclib, or trametinib in people with advanced solid tumors that have not responded to standard treatments. Participants must have certain gene changes (EGFR, HER2, HER3, HER…

This study tests whether adding a targeted drug (ipatasertib) to standard chemotherapy (paclitaxel) can shrink or slow advanced solid tumors that have PTEN or AKT gene changes. About 33 adults with cancers that have spread or can't be removed by surgery will take part. The goal i…

This early-stage trial aimed to test the safety and effectiveness of STIL101, a personalized cell therapy made from a patient's own tumor-fighting T cells, for several advanced cancers including pancreatic, colorectal, kidney, cervical, and melanoma. The treatment involved collec…

This early-phase study tests the safety of the immunotherapy drug atezolizumab given after a patient's own immune cells have been modified and infused back (adoptive cell transfer). It includes 40 adults with advanced blood or solid cancers that no longer respond to standard trea…

This study tests a combination of two drugs—veliparib and topotecan—in people with advanced solid tumors or ovarian cancer that has returned after initial treatment. The goal is to find the safest dose and see how well the drugs shrink tumors. About 88 adults are taking part in t…

This study looks at whether giving radiation therapy to people whose cancer has spread or grown after immunotherapy can help control the disease. About 230 adults with various cancers will receive radiation to see if it stops or shrinks tumors. The goal is to find a safe and effe…

This early-phase study tests the safety and best dose of a drug called copanlisib combined with immunotherapy drugs (nivolumab, with or without ipilimumab) in adults with advanced solid tumors or lymphoma that has not responded to standard treatments. The goal is to find a dose t…

This study tests a drug called telaglenastat (CB-839) in adults with advanced solid tumors or malignant peripheral nerve sheath tumors that have certain gene mutations (NF1, KEAP1/NRF2, or LKB1). The drug works by blocking an enzyme cancer cells need to grow. Researchers want to …

This early-stage trial studies the safety and best dose of combining two immunotherapy drugs—pembrolizumab and recombinant interleukin-12—in 36 adults with advanced solid tumors that have spread or cannot be removed. The goal is to see if the combination can help the immune syste…

This study tests the safety and effectiveness of combining the immunotherapy drug avelumab with other drugs and radiation in people with advanced cancers that have not responded to standard treatments. About 173 adults with various solid tumors, including prostate cancer, will re…

This study tests whether genetic testing can help doctors choose the right drug for people whose cancer has spread to the brain. Researchers will look for specific gene changes in tumor samples and then give patients a targeted medication matched to their mutation. The goal is to…

This early-phase trial tests a combination of two drugs—niraparib (a PARP inhibitor) and dostarlimab (an immunotherapy)—in people with BRCA-mutated breast, pancreas, or ovarian cancers that have spread or cannot be surgically removed. The goal is to see if the combo can shrink tu…

This study tests a combination of three drugs (copanlisib, nivolumab, and ipilimumab) in adults with advanced solid tumors that have specific gene changes (PIK3CA or PTEN). The goal is to see if adding copanlisib to standard immunotherapy works better at controlling tumor growth.…

This study tests a combination of two drugs (avelumab and M6620) in people with advanced solid tumors that have spread or can't be removed by surgery. The tumors must have a specific DNA repair defect. The goal is to find the safest dose and see how well the drugs work together t…

This study tests a drug called ceralasertib, either alone or combined with olaparib or durvalumab, in people with advanced solid tumors like kidney, bladder, pancreatic, endometrial, and prostate cancers. The goal is to see if these combinations can shrink tumors or slow their gr…

This study tests whether giving radiation therapy to high-risk but painless bone tumors can prevent future fractures, spinal cord pressure, or the need for surgery. About 280 cancer patients with multiple metastases will receive either usual care (like bone-strengthening drugs or…

This study tests the drug pembrolizumab in 21 adults with advanced solid tumors that have specific gene mutations (BRCA1, BRCA2, POLE, or POLD1). The goal is to see if the drug can shrink or control the cancer. Pembrolizumab is a type of immunotherapy that helps the immune system…

This early-phase trial is testing the safety of combining two cancer drugs—nivolumab and cabozantinib—in people with HIV who have advanced solid tumors. The study includes 8 participants with various cancers that have spread. The goal is to see if the combination can shrink or st…

This was a Phase I trial testing a drug called CB-5339 in people with advanced solid tumors or lymphomas that had stopped responding to standard treatments. The goal was to find the best dose and check for side effects. However, the study was withdrawn before enrolling any partic…

This study tests whether injecting bone cement into the spine can prevent fractures in people with cancer that has spread to the spine. About 87 patients who are at high risk for a spine fracture after radiation therapy will receive either cement plus radiation or radiation alone…

This study tests whether a drug called anamorelin, combined with physical activity and nutritional counseling, can ease severe fatigue in people with advanced solid tumors that cannot be cured. About 129 participants will receive the combination for several weeks, and researchers…

This study looks at whether adding a steroid called dexamethasone to a physical activity program can ease severe tiredness in people with advanced cancer. About 99 patients with fatigue lasting at least 2 weeks will take part. The goal is to see if the combination is practical an…

This study tests whether an open labeled placebo—a pill with no active drug that patients know is a placebo—can reduce severe fatigue in people with advanced cancer. About 100 participants will either receive the placebo or be placed on a waitlist. The goal is to see if simply be…

This study tests whether early visits with a neuropsychologist can help people with cancer that has spread to the brain maintain their quality of life after radiation therapy. About 110 adults with stage IV solid tumors and brain metastases will receive neuropsychological evaluat…

This study follows nearly 1,900 cancer patients who tested positive for COVID-19. Researchers collect blood samples, medical records, and images to see how the virus impacts their cancer treatment and overall health. The goal is to learn which factors make COVID-19 more severe in…

This study looks at whether watching a short video can help people with metastatic cancer better understand tumor genomic testing. About 243 adults with advanced breast, lung, or other solid tumors will watch the video and answer questions before and after. The goal is to see if …

This study looks at whether a special team of doctors and scientists (a genomic tumor board) can help more patients with advanced solid tumors receive treatments that match their cancer's genetic makeup. About 1,284 patients will be involved, and their doctors will either use the…

This early-phase trial looks at how DS-8201a works in patients with advanced HER2-positive solid tumors that have spread or cannot be removed. The drug targets a protein on cancer cells to damage their DNA and kill them. Researchers will compare tumor samples taken before and aft…

This study looks at how often cancer patients in a supportive care clinic experience cachexia (unintentional weight loss and loss of appetite) and the emotional burden it places on both patients and their primary caregivers. Researchers will track weight changes and use questionn…

This study uses a brain wave test (EEG) to find out if cancer patients who appear unresponsive in their final days can still hear or feel. Researchers will measure brain activity when sounds or words are played. The goal is to help families and doctors understand what patients ma…

This study tests a program where a financial navigator helps cancer patients and their partners understand insurance, set up payment plans, and find cost-saving options. The goal is to see if this support reduces financial hardship and improves quality of life. About 331 patients…

This study looks at two different ways to provide palliative care—a special type of care that helps with symptoms and stress—to people with advanced cancer and their caregivers. One method uses a virtual learning group, and the other uses one-on-one technical help. The goal is to…