METASTATIC MALIGNANT SOLID NEOPLASM

This study tested an oral drug called infigratinib in 17 adults with advanced or spreading solid tumors that have certain FGFR gene mutations. The drug works by blocking overactive FGFR proteins that help cancer grow. The main goal was to see how many patients' tumors shrank or d…

This early study tested whether giving focused radiation to brain tumors before surgically removing them is safe and might lower the chance of the cancer coming back. 26 adults with cancer that spread to the brain took part. The main goal was to see how many had serious side effe…

This early-phase study tested a new drug (ALRN-6924) combined with standard chemotherapy (paclitaxel) in 28 adults with advanced solid tumors that had spread or couldn't be removed surgically, including a type of breast cancer. The main goal was to find the safest dose and check …

This early-phase trial tested a combination of two drugs, sapanisertib and ziv-aflibercept, in 83 adults with advanced solid tumors that had spread or could not be removed by surgery. The main goal was to find the safest dose and identify side effects. The approach aims to slow t…

This early-stage trial tested a new drug (AZD8186) combined with chemotherapy (docetaxel) in 23 people with advanced solid tumors that have certain gene mutations (PTEN or PIK3CB). The main goals were to find the best dose and check for side effects. The study was completed, but …

This study tested a combination of three immunotherapy drugs (ipilimumab, nivolumab, and BMS-986156) with or without precise radiation therapy in 51 people with advanced lung, chest, or liver cancers that had spread. The main goals were to find the safest dose of BMS-986156 and t…

This early-phase trial tested a combination of three drugs—vemurafenib, cetuximab, and irinotecan—in 47 people with advanced solid tumors that have a specific BRAF V600 mutation and have spread or cannot be removed by surgery. The main goal was to find the safest dose and underst…

This study tested whether a pharmaceutical-grade psilocybin (from magic mushrooms) given in a group therapy setting is safe and can help reduce anxiety and depression in people with metastatic cancer. 55 participants received the drug along with psychological support. The main go…

This study looked at whether a second psilocybin-assisted group therapy session is safe and helpful for people with metastatic cancer who still had anxiety after their first retreat. Fifteen participants who had a partial response to the first retreat took part. The goal was to s…

This study tested a program called PLAN that helps Latino adults with advanced cancer understand and talk about the medical care they would want if they could not speak for themselves. 27 people took part. The goal was to see if the program was helpful and if it improved their kn…

This study tested a website designed to help people with advanced cancer plan for end-of-life care, including medical wishes, legal documents, and financial tasks. About 100 patients participated to see if the tool reduced distress and improved planning. The goal was to learn whe…