Can a steroid and exercise beat cancer fatigue?
NCT ID NCT03583255
First seen Jan 09, 2026 · Last updated Jun 23, 2026 · Updated 25 times
Summary
This study tests whether adding the steroid dexamethasone to a physical activity program helps reduce severe fatigue in people with advanced cancer. About 99 participants will take the drug or a placebo while doing strength and walking exercises. The goal is to see if the combination is feasible and improves fatigue more than exercise alone.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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M D Anderson Cancer Center
Houston, Texas, 77030, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Dexamethasone (a steroid that reduces inflammation)
What this could lead to
If successful, this could offer a new way to ease severe fatigue in people with advanced cancer, improving their daily quality of life.
What could go wrong
This is a mid-stage trial with only 99 participants, so results may not apply to everyone. Dexamethasone has side effects like increased appetite, mood changes, and risk of infection.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.