ADVANCED MALIGNANT SOLID NEOPLASM

This early-phase trial tests a drug called talazoparib (a PARP inhibitor) combined with one of three other drugs (palbociclib, axitinib, or crizotinib) in people with advanced or metastatic solid tumors. The goal is to find the safest dose and see if the combinations can help con…

This early-phase trial tests an experimental drug called RSC-1255, given alone or with hydroxychloroquine, in adults with advanced solid tumors (such as lung, colon, pancreatic, or brain cancer) that have not responded to or cannot tolerate standard treatments. The study has two …

This early-phase study tests the safety and best dose of TAK-243, a drug that blocks a key enzyme cancer cells need to grow. About 95 adults with advanced solid tumors or lymphoma who have tried other treatments will receive TAK-243. The goal is to find side effects and the right…

This early-phase study tests a new drug called IACS-6274, given alone or with other medicines, in people with advanced solid tumors (like melanoma, ovarian, or head and neck cancers). The main goal is to find the safest dose and understand side effects. About 54 adults will take …

This study tests whether three antibody-drug conjugates (ADCs) can shrink advanced or metastatic solid tumors that have high levels of specific proteins (Trop-2, nectin-4, or HER2). Participants will receive a drug matched to their tumor's protein profile. The goal is to see if t…

This early-stage trial tests a new drug called AU409 in about 36 adults with advanced liver cancer or other cancers that have spread to the liver. The main goals are to find the safest dose and see if the drug can shrink tumors or stop them from growing. Participants must have tr…

This early-stage trial tests two experimental drugs, peposertib and tuvusertib, together in people with advanced solid tumors that have spread or cannot be removed. The main goals are to find the safest dose and understand side effects. About 66 adults whose cancer has not respon…

This study tests whether combining three drugs (axatilimab, retifanlimab, and paclitaxel) is safe and works against advanced or metastatic solid tumors. About 38 adults with tumors that have spread or come back will receive the combination. The goal is to find the best dose and s…

This study tests two experimental drugs, ZEN003694 and entinostat, in people with advanced or treatment-resistant solid tumors, including pancreatic cancer. The goal is to find the safest dose and see if the combination can shrink tumors. About 49 participants will take part in t…

This study tests whether giving siltuximab (a drug that lowers inflammation) can prevent severe immune-related side effects when restarting immunotherapy in 40 adults with advanced cancer. Participants previously had serious side effects from immunotherapy and are now at high ris…

This early-stage trial is testing a drug called CBX-12 in people with advanced solid tumors that have spread and stopped responding to at least one prior treatment. The drug works by entering cancer cells and damaging their DNA, which can kill the cells. The study aims to see how…

This early-phase study tests a combination of two drugs—trifluridine/tipiracil (a chemotherapy) and talazoparib (a targeted therapy)—in people with advanced colorectal or gastroesophageal cancers that have spread. The main goals are to find the safest dose and understand side eff…

This study is testing whether two drugs, ZEN003694 and talazoparib, can shrink tumors in people with advanced solid cancers that have spread or cannot be removed. The trial enrolls 88 adults whose cancer has not responded to standard treatments. Researchers will also look at how …

This study tests a combination of two drugs, temozolomide and M1774, in adults with advanced solid tumors that have spread. The goal is to find the safest dose and see if the combo can shrink or slow tumor growth better than temozolomide alone. About 58 participants will take par…

This study tests a new drug called NBTXR3, which makes cancer cells more sensitive to radiation, combined with standard radiation and immunotherapy (anti-PD-1/L-1) for people with advanced solid tumors that have spread to the lungs or liver. The goal is to see if this combination…

This early-stage study tests a new chemotherapy drug, TR-002, in about 52 people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find the safest dose and check for side effects. The study also looks at whether the drug can shr…

This study tests whether olanzapine, a drug that affects brain chemicals, can help people with advanced cancer who are losing weight and appetite. About 66 adults with certain cancers (like lung, stomach, or colon) will receive either olanzapine or a placebo. The goal is to see i…

This study tests whether a low-calorie, plant-based diet that mimics fasting can reduce common side effects like rash, diarrhea, and fatigue in cancer patients receiving immunotherapy. Ten adults with advanced cancer will follow the diet and report their symptoms. The goal is to …

This study compares giving cancer treatment at home versus in a clinic for people with advanced cancers. The goal is to see if home treatment reduces stress, financial burden, and improves the overall experience. About 220 participants will be randomly assigned to receive their t…

This study is testing whether getting immunotherapy in the morning or the afternoon makes it work better for people with advanced or metastatic solid tumors like lung, kidney, or skin cancer. Researchers think the body's internal clock might affect how the immune system responds.…

This study tests a phone-based coaching program called Talking About Cancer (TAC) to help people with advanced cancer and their support person have important conversations about future medical care. The program, delivered by a social worker, aims to reduce distress and help patie…

This study looks at whether a video-based mentoring program (Project ECHO) can help doctors in underserved areas of Kenya, Nigeria, Ghana, South Africa, India, and Ethiopia provide better palliative care to patients with advanced cancer. About 312 patients and their caregivers wi…

This study screens people with advanced solid tumors to see if their cancer has specific genetic changes. Based on those results, they may be matched to a treatment trial that targets their tumor's unique genetics. The goal is to learn how well these targeted combinations work an…

This study looks at whether a video and a special doctor's visit can help young adults (ages 18-39) with advanced solid tumors or high-grade brain tumors start planning their future medical care early. The goal is to see if these tools are helpful and easy to use. About 50 people…