ADVANCED MALIGNANT SOLID NEOPLASM

This early-stage study is testing a new chemotherapy drug called TR-002 in patients with advanced solid tumors that have spread or cannot be removed by surgery and have stopped responding to standard treatments. The main goals are to find the safest dose and understand the side e…

This early-stage trial is testing whether combining three different cancer drugs is safe and effective for patients with advanced solid tumors that have spread or stopped responding to standard treatments. The three drugs work in different ways: one attacks cancer cells directly,…

This is an early-stage study to find safe doses of a new oral drug called IACS-6274. It will be tested alone and in combination with other cancer drugs in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check for side e…

This is the first human study of an experimental oral medication called AU409 for people with advanced liver cancers or other solid tumors that have spread to the liver. The main goal is to find the safest and most effective dose by testing it in a small group of patients whose c…

This early-stage trial is testing three different drug combinations to find safe doses and see if they can help control advanced solid tumors that have spread. The study will enroll about 111 adults with specific genetic features in their cancer. Researchers aim to see if combini…

This study is testing whether a combination of two oral drugs, ZEN-3694 and talazoparib, can shrink or stop the growth of advanced solid tumors that have specific genetic features. It aims to enroll 88 adults whose cancer has progressed despite prior treatments. A key goal is to …

This study is testing a new three-part treatment for patients with advanced cancer that has spread to the lungs or liver. The goal is to see if a drug called NBTXR3, which is injected directly into a tumor, makes cancer cells more sensitive to radiation. Patients also receive an …

This trial is a large screening program that matches patients with advanced solid tumors to one of many smaller treatment studies. It uses genetic testing on a patient's tumor to find specific mutations. Patients are then assigned to a drug combination designed to target those mu…

This study is testing whether giving standard cancer treatments at home is as safe and effective as giving them in a clinic. It aims to see if receiving care at home reduces stress, improves quality of life, and is preferred by patients with advanced cancers. About 220 participan…

This study is testing the safety and effectiveness of a new two-drug combination for people with advanced solid tumors, including pancreatic cancer, that have spread or stopped responding to standard treatments. The trial aims to find the best dose and see if the drugs can help c…

This early-stage study is testing the safety and best dose of a new two-drug combination for people with advanced solid tumors that have a specific marker called HER2. The treatment pairs an existing targeted cancer drug with a new pill that aims to block cancer cells' ability to…

This early-stage trial is testing a new drug called CBX-12 in patients with advanced solid tumors that have spread to other parts of the body. The drug works by damaging cancer cell DNA to kill tumors. Researchers will study how the drug affects cancer cells, measure tumor respon…

This study is testing if adding a second drug (panitumumab) to a targeted cancer pill (sotorasib) works better than the pill alone for patients with advanced solid tumors that have a specific KRAS G12C mutation. It is for people whose cancer has spread and who have already tried …

This early-stage study aims to find the safest and most effective dose of a new two-drug combination for people with advanced colorectal or gastroesophageal (stomach/esophagus) cancers that have spread. The trial will enroll about 45 adults whose cancer has progressed after at le…

This study is testing whether adding a drug called siltuximab can help cancer patients safely restart a type of immunotherapy that previously caused them severe side effects. The trial will enroll 40 adults with advanced cancer who had to stop their original immunotherapy due to …

This early-stage trial is testing a new combination of two oral drugs, peposertib and tuvusertib, in adults with advanced solid tumors that have spread and stopped responding to standard treatments. The main goals are to find the safest and most effective dose of the drug pair an…

This early-stage trial is testing a new oral drug called RSC-1255 in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see how well the drug is tolerated, both alone and combined with another medicati…

This is an early safety study for a new drug called TAK-243 in adults with advanced solid tumors or lymphoma. The main goal is to find the safest dose and understand the side effects. Researchers will give the drug to about 95 patients and closely monitor how their bodies handle …

This study aims to see if matching patients to one of three targeted cancer drugs works better for treating advanced solid tumors. It will enroll 500 adults whose cancer has spread and who have specific proteins (Trop-2, nectin-4, or HER2) in their tumor. Patients will first be s…

This early-phase trial is testing a new combination of two drugs, temozolomide and M1774, for people with advanced cancers that have spread. The main goals are to find the safest and most effective dose and to see if the combination can shrink or stabilize tumors, especially in a…

This study tests whether educational videos and guided appointments help young adults with advanced cancer discuss and document their future medical care preferences. Researchers want to see if these tools make it easier for patients to have these important conversations early in…

This study is testing whether a special low-calorie, plant-based diet can help reduce the side effects that cancer patients experience during immunotherapy. The diet, which mimics fasting, will be given to 10 patients with advanced cancer who are receiving specific immunotherapy …

This study is testing whether olanzapine, a medication that affects brain chemicals, can help cancer patients who are losing too much weight and have poor appetite. The trial will involve 66 adults with advanced cancers of the stomach, liver, pancreas, colon, or lung who have los…

This study compares two medications—olanzapine and megestrol acetate—to see which works better at improving appetite and preventing weight loss in people with advanced cancer. Researchers will enroll 360 patients who have lost weight and have poor appetite due to their cancer. Pa…

This study is testing if a special online training program (called Project ECHO) can help doctors and nurses in rural and underserved areas provide better comfort and symptom care (palliative care) for people with advanced cancer. It will measure if patients' quality of life and …