ADVANCED MALIGNANT SOLID NEOPLASM

This study tested an oral drug called infigratinib in 17 adults with advanced or spreading solid tumors that have certain FGFR gene mutations. The drug works by blocking overactive FGFR proteins that help cancer grow. The main goal was to see how many patients' tumors shrank or d…

This early-phase trial tested two drugs, cabozantinib and pamiparib, in 44 people with advanced solid tumors that had not responded to standard treatments. The goal was to find the safest dose and understand side effects. The drugs work by blocking certain enzymes that help cance…

This study tested a drug called palbociclib in 23 children and young adults (ages 1 to 21) whose cancers had come back or did not respond to standard treatment. The drug works by blocking certain proteins that help cancer cells grow. The goal was to see if the drug could shrink t…

This study tested a drug called tazemetostat in 20 children whose cancers had come back or weren't responding to treatment. The children had specific gene changes (EZH2, SMARCB1, or SMARCA4) in their tumors. The goal was to see if the drug could shrink or slow the growth of these…

This early-phase study tested a new drug (ALRN-6924) combined with standard chemotherapy (paclitaxel) in 28 adults with advanced solid tumors that had spread or couldn't be removed surgically, including a type of breast cancer. The main goal was to find the safest dose and check …

This early-phase trial tested a combination of two drugs, sapanisertib and ziv-aflibercept, in 83 adults with advanced solid tumors that had spread or could not be removed by surgery. The main goal was to find the safest dose and identify side effects. The approach aims to slow t…

This early-stage trial tested a new drug (AZD8186) combined with chemotherapy (docetaxel) in 23 people with advanced solid tumors that have certain gene mutations (PTEN or PIK3CB). The main goals were to find the best dose and check for side effects. The study was completed, but …

This study tested a combination of three immunotherapy drugs (ipilimumab, nivolumab, and BMS-986156) with or without precise radiation therapy in 51 people with advanced lung, chest, or liver cancers that had spread. The main goals were to find the safest dose of BMS-986156 and t…

This study tested a drug called samotolisib in 18 children and teens whose cancers (solid tumors, lymphoma, or related disorders) had spread, returned, or stopped responding to treatment. Only those with specific gene mutations (TSC or PI3K/MTOR) were eligible. The goal was to se…