Which method helps cancer patients best? new study tests palliative care delivery

NCT ID NCT04062552

Symptom relief Sponsor: University of Rochester NCORP Research Base Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at two different methods—a Virtual Learning Collaborative or Technical Assistance—for delivering a palliative care program called ENABLE to people with advanced cancer and their caregivers. Palliative care focuses on relieving symptoms, reducing stress, and improving quality of life alongside regular cancer treatment. The goal is to find the best way for doctors to offer these services and see how they affect patients' well-being.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 208 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2021

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * PRACTICE SITE: All participating practice clusters will be asked to identify one (or more) ENABLE coach as part of study eligibility to deliver the ENABLE program. * PRACTICE SITE: Commitment of the ENABLE coach(es) to be trained to conduct the palliative care assessment (and ENABLE sessions if the practice plans to implement them). * PRACTICE SITE: Desire to implement ENABLE, including presence of an investigator (e.g., primary affiliate principal investigator \[PI\], oncology physician, Cancer Care Delivery Research \[CCDR\] Lead) and/or program administrator/supervisor who are willing to be key contacts. * PRACTICE SITE: Demonstrated support/buy-in from oncology physicians who are willing to enroll patients. * PRACTICE SITE: Agreement of practice leadership and other individuals at the practice cluster to support/participate in the study activities. * PRACTICE SITE: If necessary, willingness to participate in a phone interview to determine capacity to implement the ENABLE program. * INDIVIDUALS AT THE PARTICIPATING PRACTICE: The ENABLE implementation team at each participating practice will include at minimum one ENABLE coach and a coordinator. Other members of the team can include the primary affiliate PI, an oncology physician or investigator, CCDR lead (if different than the coordinator, and/or the program administrator/supervisor) and other professional individuals. * ONCOLOGY PHYSICIAN: Eligible providers at practices sites are oncology physicians (i.e., medical oncologists or radiation oncologists including trainees) caring for oncology patients. If no oncology physicians are available at the practice, other providers (e.g., advanced practice providers \[APPs\]) may take on the responsibilities of the oncology physician as laid out in this protocol. We do not require that all physicians at a practice setting agree to participate. Oncology physicians must work at a participating practice cluster with no plans to leave that practice site or retire at the time of enrollment into the study. Physicians (oncologists) may serve in the ENABLE coach role and perform the palliative care assessment, ENABLE sessions and/or monthly follow-up calls per practice discretion if they have completed appropriate training. * ENABLE COACH: All participating practice clusters will be required to identify one (or more) ENABLE coaches as part of study eligibility to deliver the ENABLE program. The ENABLE coach is responsible for ensuring the ENABLE sessions and follow-up calls are completed per protocol specifications. * ENABLE COACH: A registered nurse or advanced practice provider (including a nurse practitioner or physician assistant), a physician (e.g., medical and radiation oncologists, including oncology trainees), or other professionals (e.g., social workers, chaplains) with appropriate credentials and experience to deliver ENABLE * ENABLE COACH: Individuals with an appropriate clinical license (i.e., a registered nurse, advanced practice provider, or physician, as defined above) may perform the palliative care assessment and any ENABLE sessions and follow-up calls the practice chooses to deliver * ENABLE COACH: Other professionals (e.g., social workers, chaplains) may deliver ENABLE sessions and monthly follow-up calls for which their credentials and experience are appropriate * ENABLE COACH: ENABLE coaches complete appropriate study training for any content delivered. * PATIENTS: English-speaking as not all patient measures have been validated in other languages. * PATIENTS: Age \>= 18 * PATIENTS: Willing to complete palliative care assessment and ENABLE sessions. * PATIENTS: Diagnosed within the last 90 days with an advanced cancer (defined as a newly diagnosed stage III/IV, recurrence, or progressive solid tumor cancer). Patients can receive any cancer treatment for their advanced cancer while participating in this study. * The 90-day interval refers to when the patient was made aware of their diagnosis. * PATIENTS: Expected survival of at least 6 months. * PATIENTS: Have access to telephone that can receive incoming calls. * PATIENTS: Able to provide informed consent. Exclusion Criteria: * PATIENTS: Received previous palliative care services. (Concurrent palliative care is allowed.)

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Conditions

The condition(s) this trial relates to.

cancer metastatic malignant neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Advanced malignant solid neoplasm Metastatic malignant solid neoplasm Recurrent malignant solid neoplasm

Contacts and locations

Locations

Adena Regional Medical Center

Chillicothe, Ohio, 45601, United States
Advanced Breast Care Center PLLC

Warren, Michigan, 48088, United States
Aspirus Regional Cancer Center

Wausau, Wisconsin, 54401, United States
Bhadresh Nayak MD PC-Sterling Heights

Sterling Heights, Michigan, 48312, United States
Bon Secours Saint Francis Hospital

Charleston, South Carolina, 29414, United States
Cancer Hematology Centers - Flint

Flint, Michigan, 48503, United States
Caro Cancer Center

Caro, Michigan, 48723, United States
Central Ohio Breast and Endocrine Surgery

Gahanna, Ohio, 43230, United States
Chelsea Hospital

Chelsea, Michigan, 48118, United States
Columbus Oncology and Hematology Associates Inc

Columbus, Ohio, 43214, United States
Delaware Health Center-Grady Cancer Center

Delaware, Ohio, 43015, United States
Doctors Hospital

Columbus, Ohio, 43228, United States
Dublin Methodist Hospital

Dublin, Ohio, 43016, United States
Fairfield Medical Center

Lancaster, Ohio, 43130, United States
Geisinger Medical Center

Danville, Pennsylvania, 17822, United States
Genesee Hematology Oncology PC

Flint, Michigan, 48503, United States
Genesis Healthcare System Cancer Care Center

Zanesville, Ohio, 43701, United States
Genesys Hurley Cancer Institute

Flint, Michigan, 48503, United States
Gibbs Cancer Center-Gaffney

Gaffney, South Carolina, 29341, United States
Gibbs Cancer Center-Pelham

Greer, South Carolina, 29651, United States
Grady Memorial Hospital

Delaware, Ohio, 43015, United States
Grant Medical Center

Columbus, Ohio, 43215, United States
Hawaii Cancer Care - Westridge

‘Aiea, Hawaii, 96701, United States
Hawaii Cancer Care Inc - Waterfront Plaza

Honolulu, Hawaii, 96813, United States
Hawaii Cancer Care Inc-Liliha

Honolulu, Hawaii, 96817, United States
Hematology Oncology Consultants-Clarkston

Clarkston, Michigan, 48346, United States
Henry Ford Health Saint John Hospital

Detroit, Michigan, 48236, United States
Henry Ford Health Warren Hospital

Warren, Michigan, 48093, United States
Henry Ford Madison Heights Hospital - Breast

Warren, Michigan, 48093, United States
Henry Ford River District Hospital

East China, Michigan, 48054, United States
Henry Ford Rochester Hospital

Rochester Hills, Michigan, 48309, United States
Henry Ford Saint John Hospital - Academic

Grosse Pointe Woods, Michigan, 48236, United States
Henry Ford Saint John Hospital - Breast

Grosse Pointe Woods, Michigan, 48236, United States
Henry Ford Saint John Hospital - Macomb Medical

Macomb, Michigan, 48044, United States
Henry Ford Saint John Hospital - Van Elslander

Grosse Pointe Woods, Michigan, 48236, United States
Henry Ford Warren Hospital - Breast Macomb

Macomb, Michigan, 48044, United States
Henry Ford Warren Hospital - GLCMS

Warren, Michigan, 48093, United States
Holy Cross Hospital

Fort Lauderdale, Florida, 33308, United States
Hope Cancer Center

Pontiac, Michigan, 48341, United States
Hope Cancer Clinic

Livonia, Michigan, 48154, United States
Hurley Medical Center

Flint, Michigan, 48503, United States
Huron Gastroenterology PC

Ypsilanti, Michigan, 48106, United States
Island Urology

Honolulu, Hawaii, 96813, United States
Island Urology-Hilo

Hilo, Hawaii, 96720, United States
Kapiolani Medical Center for Women and Children

Honolulu, Hawaii, 96826, United States
Knox Community Hospital

Mount Vernon, Ohio, 43050, United States
Kuakini Medical Center

Honolulu, Hawaii, 96817, United States
Lehigh Valley Hospital - Muhlenberg

Bethlehem, Pennsylvania, 18017, United States
Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, 18103, United States
Lehigh Valley Hospital-Hazleton

Hazleton, Pennsylvania, 18201, United States
Licking Memorial Hospital

Newark, Ohio, 43055, United States
Macomb Hematology Oncology PC

Warren, Michigan, 48093, United States
Marietta Memorial Hospital

Marietta, Ohio, 45750, United States
McLeod Regional Medical Center

Florence, South Carolina, 29506, United States
MedStar Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States
Mercy Clinic-Rolla-Cancer and Hematology

Rolla, Missouri, 65401, United States
Mercy Hospital Fort Smith

Fort Smith, Arkansas, 72903, United States
Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States
Mercy Hospital South

St Louis, Missouri, 63128, United States
Mercy Hospital Springfield

Springfield, Missouri, 65804, United States
Mercy Medical Center

Springfield, Massachusetts, 01104, United States
Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States
Michigan Healthcare Professionals Pontiac

Pontiac, Michigan, 48341, United States
Mount Carmel East Hospital

Columbus, Ohio, 43213, United States
Mount Carmel Grove City Hospital

Grove City, Ohio, 43123, United States
Mount Carmel Health Center West

Columbus, Ohio, 43222, United States
MyMichigan Medical Center Saginaw

Saginaw, Michigan, 48601, United States
MyMichigan Medical Center Tawas

Tawas City, Michigan, 48764, United States
Newark Radiation Oncology

Newark, Ohio, 43055, United States
Newland Medical Associates-Clarkston

Clarkston, Michigan, 48346, United States
Newland Medical Associates-Pontiac

Pontiac, Michigan, 48341, United States
Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042, United States
OhioHealth Mansfield Hospital

Mansfield, Ohio, 44903, United States
OhioHealth Marion General Hospital

Marion, Ohio, 43302, United States
Oncology Hematology Associates of Saginaw Valley PC

Saginaw, Michigan, 48604, United States
Pali Momi Medical Center

‘Aiea, Hawaii, 96701, United States
Pocono Medical Center

East Stroudsburg, Pennsylvania, 18301, United States
Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615, United States
Prisma Health Greenville Memorial Hospital

Greenville, South Carolina, 29605, United States
Queen's Cancer Cenrer - POB I

Honolulu, Hawaii, 96813, United States
Queen's Cancer Center - Kuakini

Honolulu, Hawaii, 96817, United States
Queen's Cancer Center - Pearlridge

‘Aiea, Hawaii, 96701, United States
Queen's Medical Center

Honolulu, Hawaii, 96813, United States
Riverside Methodist Hospital

Columbus, Ohio, 43214, United States
Roper Hospital

Charleston, South Carolina, 29401, United States
SMC Center for Hematology Oncology Union

Union, South Carolina, 29379, United States
SSM Health Good Samaritan

Mount Vernon, Illinois, 62864, United States
Saint Ann's Hospital

Westerville, Ohio, 43081, United States
Saint Mary's Hospital

Centralia, Illinois, 62801, United States
Saint Mary's Oncology/Hematology Associates of Marlette

Marlette, Michigan, 48453, United States
Saint Mary's Oncology/Hematology Associates of West Branch

West Branch, Michigan, 48661, United States
Southern Ohio Medical Center

Portsmouth, Ohio, 45662, United States
Spartanburg Medical Center

Spartanburg, South Carolina, 29303, United States
Straub Clinic and Hospital

Honolulu, Hawaii, 96813, United States
Strecker Cancer Center-Belpre

Belpre, Ohio, 45714, United States
The Cancer Center of Hawaii-Liliha

Honolulu, Hawaii, 96817, United States
The Cancer Center of Hawaii-Pali Momi

‘Aiea, Hawaii, 96701, United States
The Mark H Zangmeister Center

Columbus, Ohio, 43219, United States
ThedaCare Cancer Care - Shawano

Shawano, Wisconsin, 54166, United States
ThedaCare Regional Cancer Center

Appleton, Wisconsin, 54911, United States
ThedaCare Regional Medical Center - Neenah

Neenah, Wisconsin, 54956, United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton, Michigan, 48114, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton

Canton, Michigan, 48188, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

Chelsea, Michigan, 48118, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Ypsilanti, Michigan, 48197, United States
Trinity Health Medical Center - Brighton

Brighton, Michigan, 48114, United States
Trinity Health Medical Center - Canton

Canton, Michigan, 48188, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106, United States
Trinity Health Saint Joseph Mercy Oakland Hospital

Pontiac, Michigan, 48341, United States
Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154, United States
University of Hawaii Cancer Center

Honolulu, Hawaii, 96813, United States
University of Michigan Health - Sparrow Lansing

Lansing, Michigan, 48912, United States
Wilcox Memorial Hospital and Kauai Medical Clinic

Lihue, Hawaii, 96766, United States

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