HUMAN IMMUNODEFICIENCY VIRUS

This early-stage trial tested a therapeutic DNA vaccine called ICVAX in 45 adults with well-controlled HIV on antiretroviral therapy (ART). The goal was to see if the vaccine is safe and can boost the body's own immune cells to fight HIV. Participants received either the vaccine …

This study looked at how well the HPV vaccine protects against HPV infections that can cause cancer in Rwandan women aged 18-28, both with and without HIV. Researchers measured infections and antibody levels years after vaccination, and also tested a simple, low-cost way to confi…

This study tested a new program called THRIVE for people with HIV who are not regularly seeing a doctor. The program helps them stay in HIV care after leaving the hospital. 75 adults took part, and the study looked at whether the program was acceptable and if it improved viral lo…

This study aims to understand why some people with HIV still have high virus levels despite taking combination antiretroviral therapy (ART). Researchers will monitor 26 participants during hospital stays and follow-ups to see if directly observed medication and tailored support c…

This study looked at whether using an anti-cancer cream (5-fluorouracil) in the vagina after surgery is acceptable and helpful for treating cervical precancer in 180 South African women living with HIV. The goal was to see if women would stick with the treatment and find it accep…

This study tested whether a single infusion of two long-acting antibodies (3BNC117-LS and 10-1074-LS) plus repeated doses of an immune-stimulating drug (N-803) can safely control HIV in people who temporarily stop their daily antiretroviral therapy. 28 adults with well-controlled…

This study tested whether artesunate vaginal inserts, a medicine used for malaria, can help clear HPV after standard cervical precancer treatment in women living with HIV. 120 women used the inserts or a placebo for 5 days on, 1 week off, repeated 3 times. The goal was to see if …

This study tested whether giving recombinant human growth hormone for 48 weeks could reduce the hidden HIV reservoir in 22 adults already on successful antiretroviral therapy (ART). The goal was to see if this approach could help the immune system naturally control the virus, mov…

This study tested whether combining a peer navigator (a trained buddy) with a mobile app helps Hispanic and Black people living with HIV keep the virus under control. 309 adults in San Diego took part. The goal was to see if this approach improves viral suppression and keeps peop…

This study tested whether infusions of two lab-made antibodies (3BNC117 and 10-1074) can safely control HIV in people who temporarily stop their daily antiretroviral therapy (ART). Twenty-six adults with well-controlled HIV received seven antibody infusions and were monitored for…

This study tested whether delivering support through existing friend groups helps people living with HIV stay in medical care and reduce heavy drinking. Researchers enrolled 341 adults in St. Petersburg, Russia, who were HIV-positive and part of social networks with other HIV-pos…

This study tested a way to identify pregnant women with HIV who are at risk of dropping out of care or having high virus levels. Researchers in Kenya gave extra support to those at highest risk. The goal was to help mothers stay healthy and prevent passing the virus to their babi…

This study tested a program to help young men (ages 17-24) who have sex with men use HIV self-testing and PrEP medication to prevent HIV. The program provided information, motivation, and skills through online modules. 118 participants joined this pilot study to see if the approa…

This study tested a program where male-female health worker pairs visited pregnant women and their male partners at home in Kenya. The goal was to encourage couples to test for HIV together and improve family health. About 1,600 pregnant women and their partners took part, and th…

This study tested whether mobile counseling could help Romanian gay and bisexual men reduce HIV risk and improve mental health. 300 men completed surveys and 8 online sessions with a counselor or by reading health information. The program aimed to lower risky sex and heavy drinki…

This study tested a program to help gay and bisexual men in Romania start and stick with PrEP, a daily pill that prevents HIV. 120 men at high risk for HIV took part. The program combined in-person visits with mobile health tools to support PrEP use. Results will guide HIV preven…

This study tested a tablet-based tool and clinic training to help cisgender women learn about HIV prevention options like PrEP. 141 women from a Florida clinic participated. The goal was to see if the tool helped women make informed choices and start prevention methods.

This study tested a 9-session program that uses cognitive-behavioral techniques to help people living with HIV quit smoking by reducing anxiety and depression. 131 daily smokers who were motivated to quit took part. The goal was to see if the program led to higher quit rates comp…

This early-stage study tested a single dose of a lab-made antibody called 3BNC117-LS in 43 adults, both with and without HIV. The main goals were to see if it is safe and how long it remains in the bloodstream. No treatment or prevention benefit was measured; the study focused on…

This study looked at 217 Hispanic people living with HIV in California, Mexico, and Puerto Rico to see if the types of bacteria in the anus are linked to HPV infection or anal precancer. Researchers compared the anal microbiome between those with and without high-risk HPV or prec…

This study looked at how veterans with HIV use My HealtheVet, an online health tool, to manage their condition. Researchers reviewed medical records and interviewed 123 veterans and their healthcare providers. The goal was to understand what helps or hinders use of the tool and t…

This study followed 200 transgender and non-binary people living with HIV across Europe for 18 months. Researchers collected data from routine blood tests to see how well HIV treatment was working. The goal was to learn more about this group's health needs and help shape future t…