HUMAN IMMUNODEFICIENCY VIRUS

This is an early safety study testing two different schedules for giving a combination of experimental HIV vaccines. It will enroll 78 healthy adults at low risk for HIV to see if the vaccines are safe and if they trigger an immune response. Researchers are comparing a standard s…

This study is testing a treatment made from donated immune cells grown in a lab. These cells are designed to find and kill BK and JC viruses, which can cause serious infections in people with weakened immune systems, such as those with cancer, HIV, or a transplant. The goal is to…

This study aims to learn about the safety and effectiveness of kidney transplants from donors with HIV to recipients who also have HIV. Researchers will follow 30 adults with HIV who need a kidney transplant and receive one from either a living or deceased donor who also has HIV.…

This study is testing if adding a new drug called lenacapavir to standard HIV medication can reduce the hidden, inactive virus that persists in the body. It will involve 50 adults whose HIV is already well-controlled with long-term therapy. Researchers will compare the size of th…

This study is testing if baricitinib, an existing drug for rheumatoid arthritis, can reduce the amount of hidden HIV virus in the brain and spinal fluid. It involves 95 adults whose HIV is well-controlled with standard medication. Researchers will compare the drug to a placebo, u…

This study is testing a new support program to help people with HIV stay on their medication. It will compare a 'club' model—where participants pick up 6 months of medicine and get peer support—to standard clinic visits. The main goal is to see if this approach helps people maint…

This study is testing whether two doses of the HPV vaccine work as well as three doses for women living with HIV. Researchers want to see if a simpler vaccination schedule can still provide strong protection against the virus that causes cervical cancer. The results could help ma…

This study aims to see if busy hospital emergency rooms can be used to find people at high risk for HIV and connect them to prevention services. Researchers will offer HIV testing and information about prevention drugs (PrEP) to all eligible patients in emergency departments in S…

This study is testing a short counseling program designed to help teens living with HIV manage stress and build resilience. Researchers in Eswatini will enroll 140 adolescents to see if the program is practical, acceptable, and can improve their mental well-being and quality of l…

This study aims to understand the genetic makeup of cancers that occur in people with viral infections, HIV, or immune system disorders like Castleman disease. Researchers will collect and analyze tissue samples from adult participants to look for genetic changes that might expla…