HUMAN IMMUNODEFICIENCY VIRUS

This study looks at whether women living with HIV can get the same protection from the HPV vaccine with 2 doses instead of the usual 3. Researchers will compare immune responses in 275 Canadian women aged 18-45 who have never received the HPV vaccine. If 2 doses work as well, it …

This early-stage study tests whether a new HIV vaccine schedule is safe and can trigger an immune response in healthy adults. About 78 volunteers will receive either the vaccine or a placebo. The goal is to see if a rapid, escalating dose approach works better than a standard sch…

This early-stage trial tests a therapeutic DNA vaccine called ICVAX in 22 adults with HIV who are stable on antiretroviral therapy (ART). The goal is to see if the vaccine is safe and can boost the body's immune cells to better fight HIV. Participants receive four vaccine doses o…

This study tests whether baricitinib, an FDA-approved arthritis pill, can reduce hidden HIV in the brain. About 95 adults with well-controlled HIV will receive baricitinib or a placebo for 12 weeks. Researchers will use blood tests, spinal taps, and brain scans to measure changes…

This study tests whether adding the drug lenacapavir to standard HIV treatment can reduce the hidden viral reservoirs that prevent a cure. About 50 adults with well-controlled HIV will either continue their usual therapy or receive lenacapavir injections plus pills. Researchers w…

This study tests whether kidney transplants from HIV-positive donors are safe and effective for HIV-positive patients with kidney failure. About 30 adults with well-controlled HIV will receive a kidney from an HIV-positive donor. Researchers will track patient survival and kidney…

This study compares two antibiotics—cefixime (a pill) and penicillin G (a shot)—for treating early syphilis in 400 adults, including those with well-controlled HIV. The goal is to see if the pill works as well as the standard shot. Participants must have a positive blood test and…

This study tests whether joining a support club helps people with HIV stick to their medication and keep the virus under control. Participants either join a club where they pick up 6 months of medicine and get peer support, or receive standard clinic care. The goal is to see if t…

This study tests whether specially grown donor immune cells (called cytotoxic T lymphocytes) can safely and effectively treat BK and JC virus infections in 100 people with cancer, HIV/AIDS, or organ transplants. These viruses can cause serious problems like kidney damage or brain…

This study looks at whether a team-based mental health program can help pregnant and new mothers living with HIV in Kenya feel better and stay healthy. About 900 women will receive extra mental health support alongside their regular HIV care. The goal is to reduce depression and …

This study tests whether a very low dose of naltrexone, a drug usually used for addiction, can reduce chronic nerve pain in people with HIV. Researchers will enroll 60 adults with HIV and neuropathic pain to take the drug for 12 weeks and report their pain levels. The goal is to …

This study tests a program called PRISM that teaches stress management skills to teens aged 10-19 living with HIV in Eswatini. The goal is to see if it reduces psychological distress and improves quality of life compared to standard care. About 140 teens will take part, and resea…

This study will test all patients who come to two busy emergency rooms in Cape Town, South Africa for HIV. The goal is to find out how many people have HIV or are at high risk and could benefit from a daily pill that prevents HIV (called PrEP). Researchers will then connect those…

This study aims to learn more about the genes involved in cancers that are linked to viruses or occur in people with HIV or other immune problems. Researchers will collect tissue, blood, and urine samples from 280 adults to compare genes in cancer cells with normal cells. The goa…

This study looks at whether harm reduction care—where healthcare providers focus on reducing harm rather than judging drug use—can improve health outcomes and reduce stigma for people living with HIV who use drugs. Researchers will study about 768 patients and their providers at …