GYNECOLOGIC CANCER

This study tests a drug called atezolizumab in about 200 adults with advanced solid tumors (like breast, lung, or colon cancer) whose tumor DNA suggests the drug might help. Participants get the same dose every 3 weeks, and researchers check if their cancer shrinks or stops growi…

This study looks at whether proton therapy can safely treat tumors that have returned after previous radiation. Unlike standard X-ray radiation, proton beams are more targeted and may spare healthy tissue. The trial will enroll 1,800 adults with various cancers to see if this app…

This study tests a new radiation technique for people with cervical cancer or pelvic cancer that has come back. It is for those who cannot get standard brachytherapy because of unusual anatomy or large tumors. The goal is to see if this method can control the cancer in the treate…

This study tests whether the drug belzutifan can shrink or slow the growth of clear cell cancers of the ovary, uterus, cervix, vagina, or vulva that have come back or not gone away. About 32 adults will receive belzutifan pills and be monitored for tumor response and side effects…

This early-phase study tests a new treatment called GC203 TIL, which uses a patient's own immune cells that are modified in a lab to better attack cancer. The trial enrolls 18 adults with advanced solid tumors (including breast, lung, and gastrointestinal cancers) who have not re…

This study tests a combination of two drugs, cabozantinib and dostarlimab, in 37 women whose gynecologic carcinosarcoma has returned after at least one prior chemotherapy. The goal is to see if the combination can keep the cancer from growing for at least 6 months. Participants w…

This study tests whether adding compression to cold therapy (cryocompression) works as well as cold therapy alone to prevent or reduce nerve damage caused by chemotherapy in people with gynecologic cancers. About 190 participants receiving paclitaxel will be randomly assigned to …

This study is testing a web-based application that lets cancer patients report side effects from radiation therapy in real time. About 30 people with gynecologic, urologic, or breast cancer will use the app to answer simple questionnaires. Their responses are sent securely to the…

This study tests a stress management program called Vietnamese Self Help Plus (vSH+) for women with breast or gynecologic cancer in Vietnam. About 285 participants will either receive the program or standard care. The goal is to see if the program reduces anxiety and depression a…

This study tests a program called BOLSTER designed to help people with advanced gynecologic or gastrointestinal cancers and their caregivers. The program provides extra support for those with complex care needs like ostomies or feeding tubes. Researchers want to see if it improve…

This study tests a non-invasive brain stimulation technique called rTMS to see if it can reduce nerve pain caused by chemotherapy in breast and gynecologic cancer survivors. About 19 women with persistent pain will receive multiple rTMS sessions. The main goal is to measure chang…

This study tests whether a virtual mind-body program called IM@Home can reduce fatigue and improve quality of life for adults with head and neck, thoracic, gynecologic, or other cancers who are receiving treatments like chemotherapy or radiation. About 480 participants will be en…

This study looks at whether a special day-hospital visit with a team of experts can help women who finished treatment for ovarian or endometrial cancer get the supportive care they need. About 268 women in remission will either receive a personalized care plan with a day-hospital…

This study tests whether a personalized digital exercise program and virtual support group can help gynecologic cancer patients feel better during treatment. About 60 women receiving chemotherapy or surgery will participate. The goal is to see if the program is practical and help…

This study tests whether a headband with special semiconductors can help with memory and thinking problems (chemo brain) after breast or gynecologic cancer treatment. About 50 adults who finished chemotherapy within the last 90 days will wear the headband for 18 hours a day for 3…

This study looks at whether a special retreat program called 'Via Shalva' is helpful and practical for people who have finished treatment for breast or gynecologic cancer. About 30 survivors will take part, and researchers will check changes in quality of life, stress, and other …

This study tests whether a mobile cognitive training app can reduce 'chemobrain'—memory and thinking problems caused by chemotherapy—in women with gynecologic cancer. About 64 participants will use the app and have their brain function measured with tests and surveys. The goal is…

This pilot study tests if brodalumab, a drug approved for autoimmune diseases, can safely reduce severe side effects caused by cancer immunotherapy. About 11 adults with various solid tumors who have immune-related side effects will receive brodalumab. The goal is to see if it lo…

This study looks at whether using the Headspace mindfulness app before surgery or chemoradiation can help patients with endometrial or cervical cancer use fewer opioids and feel better. About 120 participants will be randomly assigned to use the app or not. The goal is to see if …

This study tests whether guided imagery—a relaxation technique using calming mental images—can reduce nausea, vomiting, and anxiety while improving quality of life in women receiving chemotherapy for gynecologic cancer. About 158 participants will be randomly assigned to either p…

This study tests whether a personalized activity coaching program can help women with endometrial cancer feel less tired during pelvic radiation therapy. Sixteen participants will receive coaching sessions to boost their energy and daily functioning. The goal is to see if this ap…

This study is testing whether brief, guided mindfulness meditations during daily radiation therapy can lower anxiety for people with breast or gynecologic cancer. About 34 participants will either listen to a guided meditation during treatment or receive standard care. Researcher…

This study tests whether the drug riluzole can prevent memory and thinking problems (often called 'chemo brain') in people receiving chemotherapy for various cancers. About 24 adults with breast, lung, or other cancers will receive either riluzole or a placebo during their chemo.…

This study tests whether guarana, a natural plant extract, can improve fatigue in people with neuroendocrine tumors or gynecologic cancers. About 86 adults will take guarana or a placebo for up to 42 days, and researchers will measure changes in fatigue and quality of life. The g…

This study is testing a program called MyCarePulse and ASCENT to help cancer patients overcome food-related challenges. About 100 adults recently diagnosed with certain cancers will either receive the program or standard care. Researchers will measure changes in food security, di…

This study looks at whether a simple bedside lung ultrasound can spot early signs of lung trouble in women admitted to the intensive care unit for pregnancy complications or gynecologic cancer. Researchers will track different ultrasound patterns and see how they relate to patien…

This study aims to learn more about the cells and molecules found in uterine washings from 50 women undergoing gynecologic surgery. Researchers will analyze these samples to better understand gynecologic conditions like cancer. The study does not provide treatment but may help im…

This study is testing a web-based tool called CARE that gives cancer patients information about treatment costs, health insurance, and financial resources. About 430 adults with gynecologic, prostate, lung, or colorectal cancer will use the tool to see if it helps them feel more …

This study tests whether 3D-printed custom applicators can deliver radiation more precisely than standard cylinder applicators for gynecologic cancers like endometrial, vaginal, and vulvar cancer. Ten participants will receive brachytherapy with a personalized 3D-printed mold. Th…

This study is collecting blood, tissue, urine, and saliva from 7,000 people with many types of cancer to look for tiny bits of cancer DNA left after treatment. The goal is to find out if this DNA test can spot remaining cancer early and help doctors decide on next treatments. Par…

This study looks at 120 women having laparoscopic gynecologic surgery (including for cancer) to compare two ways of using the breathing machine: volume-controlled and pressure-controlled ventilation. The goal is to see which method better protects lung function and brain oxygen l…

This study follows 500 adults with newly diagnosed gynecologic cancer to understand how frailty—being more vulnerable to stress from illness—affects their recovery and quality of life. Researchers will measure physical signs like weight loss, weakness, and slow walking. No new tr…

This study aims to gather detailed information from 10,000 people with endometrial cancer across Italy. Researchers will look at how the cancer's molecular and clinical features affect disease-free survival and overall survival. The goal is to create a comprehensive database to b…

This study collects blood, tumor tissue, and other fluids from 510 people with advanced ovarian cancer. Researchers will analyze these samples to find genetic and immune markers that may predict how long patients live or how well they respond to treatment. Results may be shared w…

This study will collect genetic information and health records from 25,000 people who have cancer or are at risk for it. The goal is to learn more about what drives cancer and how to better tailor treatments. Participants will not receive a new therapy, but their data may help fu…

This study aims to learn more about gene and protein changes in gynecologic cancers (ovarian, uterine, cervical, and others). Researchers will collect tissue and blood samples from 1,000 participants before surgery or radiation. By analyzing these samples, they hope to better und…

This study is a large registry that will follow 8,000 cancer patients who receive radiation therapy guided by an MR-Linac, a machine that combines an MRI scanner with a radiation beam. The goal is to see if this technology helps people live longer, controls tumors better, and imp…

This study looks at which intravenous fluid—albumin or Ringer's solution—is better at increasing blood volume during laparoscopic surgery. About 60 adults having abdominal surgery will receive one of three fluid doses. The goal is to see which fluid keeps the heart and blood vess…

This study is collecting blood samples from 1,000 people with digestive, gynecologic, or breast cancer to study tiny bits of tumor DNA and particles called exosomes floating in the blood. Researchers want to see if these markers can help predict how the cancer will behave, whethe…

This study looks at why cancer patients feel very tired during chemotherapy and radiation. Researchers will collect blood and stool samples from 125 adults with different cancers before, during, and after treatment. They aim to find links between fatigue and changes in genes and …