GYNECOLOGIC CANCER

This early-stage trial tests a new treatment for people with advanced solid tumors (like head and neck, melanoma, or lung cancer) that haven't responded to standard therapies. Doctors take a patient's own immune cells from the tumor, pick out the ones best at fighting cancer, gro…

This study tests whether combining two drugs, pembrolizumab and lenvatinib, can shrink tumors or slow cancer growth in people with a rare type of ovarian cancer that has come back. About 30 adults with clear cell ovarian cancer will receive the drug combination. The main goals ar…

This study tests whether using MRI during brachytherapy (a type of internal radiation) can help doctors deliver treatment more accurately for gynecologic cancers. About 49 participants will receive standard brachytherapy, some with an MRI tracker to guide the procedure. The goal …

This early-phase trial tests a new treatment called FT536 for people with ovarian, fallopian tube, or primary peritoneal cancer that has come back. The treatment is given directly into the belly three times in one week, after a short course of chemotherapy to prepare the body. On…

This study tests a new type of MRI scan that is faster and less affected by movement, aiming to produce clearer images of gynecologic tumors. Researchers will compare this new method to traditional MRI in 24 women with gynecologic cancer and healthy volunteers. The goal is to see…

This study tests a program that combines physical therapy with coping skills training to help women who have had pelvic radiation for cancer improve their sexual function. About 12 participants who completed radiation within the last 5 years will try the program. The goal is to s…

This study tests a device called SensoniQ® that uses low-frequency soundwaves to prevent or reduce nerve pain from chemotherapy in people with gynecologic cancer. About 80 participants will receive the treatment either during their first round of chemo or after they already have …

This study explores whether acupuncture can improve memory, focus, and thinking problems that some people experience after cancer treatment. It includes 48 adults who have finished initial treatment for breast, colorectal, prostate, or gynecologic cancer and report moderate to se…

This study looks at whether a 12-week program of online chair-based exercise and health education, along with a full geriatric assessment, can help older adults (65+) with cancer and their support person. The goal is to see if this approach is practical and helps improve physical…

This study tests a program that helps cancer patients and their caregivers manage difficult emotions and communicate better about the illness. It includes a version tailored for Latinx participants. The goal is to reduce distress, improve quality of life, and help families discus…

This study tests a program called Journey Ahead that helps women with gynecologic cancers (like ovarian, endometrial, or cervical cancer) improve their coping and communication skills. About 30 women who have been diagnosed or had a recurrence in the past 5 years will take part. …

This study aims to see if it's possible to use electronic questionnaires to track symptoms in 100 gynecologic cancer patients before, during, and after radiation therapy. Participants will complete surveys at various time points up to two years after treatment. The main goal is t…

This study measures oxygen levels inside cervical cancer tumors during a type of radiation treatment called brachytherapy. Ten adults with cervical cancer will have tiny oxygen sensors placed in their tumors during the procedure. The goal is to learn how oxygen levels relate to t…

This study tests a program called IGNITE-TX that uses a website and a genetic family navigator to help relatives of people with hereditary cancer get free genetic counseling and testing. It involves 205 adults who have a known cancer gene mutation and their at-risk family members…

This study follows 100 women with breast or gynecological cancer to see if what they eat in the month before starting chemotherapy is linked to levels of a protein called hepcidin. Researchers will also check if hepcidin levels relate to how much of the planned chemo dose patient…

This study aimed to compare two ways of helping patients breathe during anesthesia for robotic gynecological or genitourinary cancer surgery. The goal was to see if a newer method (APRV) improves lung function compared to the standard method (CMV). The study was withdrawn before …

This study was designed to test a mobile health app that helps patients with recurrent head and neck or gynecologic cancers track their symptoms, treatment side effects, and quality of life. The goal was to see if patients find the app easy to use and helpful. However, the study …

This study looks at how gynecological cancer survivors feel and function after finishing their main treatment. About 1,100 women who are currently cancer-free will fill out questionnaires about their quality of life, anxiety, and sexual health. The goal is to learn what matters m…