GLIOBLASTOMA MULTIFORME

This study tests a vaccine called SurVaxM, given alongside standard chemotherapy, for people with a newly diagnosed aggressive brain cancer (glioblastoma). The vaccine is designed to train the body's immune system to recognize and attack cancer cells. The main goal is to see if a…

This early study tested a personalized DNA vaccine in 9 people with a severe type of brain cancer called glioblastoma. The vaccine was made specifically for each patient based on their tumor's unique features. The main goals were to see if the vaccine was safe, possible to create…

This study tests a drug called ACP-196 (acalabrutinib) in 24 adults with recurrent glioblastoma, an aggressive brain cancer that has returned after standard treatment. Participants take the drug by mouth once or twice daily. The main goal is to see if the drug can shrink tumors o…

This study tests whether the drug ribociclib can reach brain tumors in people with recurrent high-grade glioma or meningioma. About 48 participants will take the drug before their scheduled tumor removal surgery. Researchers will measure how much of the drug gets into the tumor a…

This study tests whether adding the targeted drug pazopanib to standard chemotherapy (temozolomide) can safely control glioblastoma, an aggressive brain cancer. About 51 adults who had surgery and chemoradiation will receive the combination. The main goal is to find the best dose…

This study tests an experimental drug called ST101 in people with advanced solid tumors, including glioblastoma, melanoma, breast, and prostate cancers that have spread or cannot be removed by surgery. The trial has two parts: first, finding a safe dose, and second, seeing if the…

This early-phase study tests an experimental oral drug called DSP-0390 in 39 adults whose high-grade glioma (a fast-growing brain tumor) has come back after prior treatment. The main goals are to check the drug's safety and find the best dose to use in future studies. Researchers…

This early-phase study tests whether adding the experimental drug S-Gboxin to standard radiation and chemotherapy can help people with glioblastoma or diffuse midline glioma, two aggressive brain cancers. Ten participants whose tumors have returned or worsened will receive the co…

This study tests whether adding high-dose vitamin C to the usual treatment (radiation and chemotherapy) helps adults with a newly diagnosed aggressive brain tumor called glioblastoma. About 90 participants will receive the vitamin C infusions alongside standard care. The goal is …

This study planned to test a new treatment combining CYNK-001 (natural killer cells from donated cord blood) with interleukin-2 in adults whose glioblastoma had returned and could be surgically removed. The goal was to see if this combination was safe and could extend the time be…

This study aimed to test an experimental virus therapy called G207, combined with a single dose of radiation, in children whose high-grade glioma had come back after prior treatment. The virus was injected directly into the brain tumor to kill cancer cells and trigger an immune r…

This early-stage study tested the safety and best dose of vorinostat when given with the chemotherapy drug temozolomide in 83 adults with aggressive brain tumors called malignant gliomas. The goal was to see if adding vorinostat could make the tumor cells more sensitive to chemot…

This study tests whether adding the anti-viral drug valganciclovir to standard treatment can help people with glioblastoma, an aggressive brain cancer, live longer. The drug targets cytomegalovirus (CMV), which is often found in these tumors and may make them more aggressive. Abo…

This early-phase trial tests the drug niraparib in up to 42 people with two types of brain tumors: newly-diagnosed glioblastoma (a fast-growing cancer) and recurrent IDH-mutant glioma (a slower-growing type). The study first checks if the drug reaches the tumor and shows biologic…

This study tests a drug called rhIL-7-hyFc in people with high-grade gliomas (a type of brain tumor) whose immune cell counts are low after standard radiation and chemotherapy. The goal is to see if the drug can safely increase lymphocyte levels, which help fight infections. Abou…

This early-stage study tests a new surgery for people with a returning brain tumor called glioblastoma. Doctors remove the tumor and then place a piece of tissue from the patient's belly into the empty space. The goal is to see if this is safe and can help deliver treatments past…

This early-phase trial tests whether adding high-dose vitamin C and an iron drug (ferumoxytol) to standard radiation and chemotherapy can help control glioblastoma, an aggressive brain tumor. Seventeen adults with newly diagnosed glioblastoma will receive the combination. The mai…

This early-phase trial tests a vaccine called SurVaxM in 35 children and young adults with brain tumors that have come back or are hard to treat. The vaccine is designed to teach the immune system to find and destroy cancer cells that carry a protein called survivin. Participants…

This pilot study tests whether an energy-restricted ketogenic diet (ERKD) can help control glioblastoma, an aggressive brain cancer. Sixteen adults with newly diagnosed glioblastoma will follow the diet while receiving standard radiation and chemotherapy. The goal is to see if th…

This early-phase study tests a new treatment for glioblastoma, an aggressive brain cancer. The approach uses a patient's own immune cells, modified in the lab to better recognize and attack the tumor, combined with chemotherapy. The main goal is to check the safety of this therap…

This study tests whether adding an experimental drug called NanO2 to standard radiation and chemotherapy can help people with newly diagnosed glioblastoma, an aggressive brain cancer. NanO2 is designed to deliver more oxygen to tumors, which may make radiation work better. About …

This early-stage trial tests whether combining a precise form of radiation (stereotactic radiosurgery) with two immunotherapy drugs (MBG453 and spartalizumab) is safe for people whose glioblastoma has come back. The study includes 16 adults with recurrent GBM. The main goal is to…

This early-phase trial tests whether adding the drug AZD1390 to standard radiation therapy can help people with a fast-growing brain tumor called glioblastoma (grade 4 glioma). The study includes both newly diagnosed and recurrent patients. First, researchers measure how much dru…

This early-phase study tests a new treatment called CHM-1101 for people with a fast-growing brain cancer (glioblastoma) that has returned or worsened. The therapy uses specially engineered immune cells (CAR T-cells) designed to find and attack cancer cells carrying a specific mar…

This early-phase trial is testing whether giving two immune-boosting drugs (nivolumab and ipilimumab) before surgery can help fight recurrent glioblastoma, a fast-growing brain cancer. About 63 adults whose tumor has returned after standard treatment will receive the drugs or a p…

This study tests whether adding the experimental drug BPM31510 (with vitamin K1) to standard radiation and chemotherapy can help people with newly diagnosed glioblastoma live longer without their cancer growing. About 50 adults with this aggressive brain tumor will receive the co…

This early-stage study tests whether adding an experimental drug called OKN-007 to standard chemotherapy and radiation is safe for people with newly diagnosed glioblastoma, a fast-growing brain cancer. About 27 adults who have had surgery for their tumor will receive the combinat…

This trial tests an implantable ultrasound device that temporarily opens the blood-brain barrier, allowing chemotherapy to reach brain tumors. It includes 57 adults with recurrent glioblastoma who have already tried 1-2 treatments. The goal is to find a safe dose and see if this …

This early-stage study tests a genetically engineered virus (rQNestin34.5v.2) that is injected directly into recurrent brain tumors to see if it is safe and what dose works best. About 62 adults with certain types of brain cancer that have come back or worsened are taking part. T…

This study tests whether adding the experimental drug LAM561 to standard radiation and chemotherapy can help people with newly diagnosed glioblastoma, a fast-growing brain tumor. About 144 adults aged 18 to 75 will receive either LAM561 or a placebo alongside their usual treatmen…

This study tests a new treatment called Temferon for people with glioblastoma, a fast-growing brain cancer. The therapy uses a patient's own blood stem cells, modified to deliver interferon directly to the tumor. Up to 27 patients with a specific genetic marker (unmethylated MGMT…

This early-stage trial tested the safety and best dose of a drug called APX005M in 32 children with brain tumors that had come back or were hard to treat, including a type of brain stem glioma. The drug works by activating the immune system to attack tumor cells. The main goals w…

This study tests a new way to deliver two cancer drugs (bevacizumab and carboplatin) directly to the brain through an artery for people with recurrent glioblastoma or anaplastic astrocytoma. The goal is to see if repeated doses are safe and can shrink tumors or slow their growth …

This study tests whether giving a higher radiation dose to a brain area called the subventricular zone (where stem cells live) can delay glioblastoma from coming back. About 60 adults with newly diagnosed glioblastoma will receive standard radiation and chemo, but half will get e…

This pilot study aimed to see if a diet low in two specific nutrients (cysteine and methionine) could affect metabolism in patients with recurrent gliomas. Up to 30 participants were to be randomly assigned to either a normal diet or the special diet for 2, 4, or 7 days before st…