GLIOBLASTOMA MULTIFORME

This study tests whether adding high-dose vitamin C to the usual treatment (radiation and chemotherapy) helps adults with a newly diagnosed aggressive brain tumor called glioblastoma live longer. About 90 participants will receive the vitamin C infusions alongside standard care. …

This early-phase trial tests whether adding the drug AZD1390 to standard radiation can help people with a fast-growing brain tumor called glioblastoma. About 97 participants with either new or returning tumors will receive the drug before and during radiation. The study first che…

This trial tests a new gene therapy called Temferon for glioblastoma, a fast-growing brain cancer. It involves taking a patient's own blood stem cells, modifying them to produce an immune-boosting protein, and giving them back after chemotherapy. The study includes up to 27 patie…

This study tests whether adding the experimental drug LAM561 to standard radiation and chemotherapy can help people with newly diagnosed glioblastoma, an aggressive brain cancer. About 144 adults aged 18 to 75 will receive either LAM561 or a placebo alongside their usual treatmen…

This study tests a vaccine called SurVaxM in 35 children with brain tumors that have come back or are hard to treat. The vaccine teaches the body's immune system to find and destroy tumor cells carrying a protein called survivin. The goal is to see if it is safe and helps control…

This program provides an experimental drug called gallium maltolate (GaM) to adults with glioblastoma, a severe brain cancer, that has returned or not responded to standard treatments. It is for patients aged 18 and older who have run out of other options and may still benefit. T…

This study tests a new drug called ST101 in people with advanced solid tumors that cannot be removed by surgery or have spread. The goal is to find a safe dose and see if the drug can shrink tumors. About 125 adults with cancers like glioblastoma, melanoma, breast, or prostate ca…

This early-phase study is testing whether adding the experimental drug S-Gboxin to standard treatment (radiation and chemotherapy) can help control glioblastoma, a fast-growing brain cancer. About 10 adults whose tumor has returned or worsened will receive the combination. The ma…

This early-phase study tested an experimental drug called APX005M in 32 children with brain tumors that had come back or were hard to treat, including a type of brain stem glioma. The goal was to find the safest dose and see if the drug could help the immune system attack the tum…

This early-phase study tests a new treatment for glioblastoma, a fast-growing brain tumor. The therapy uses a patient's own immune cells, modified to target a protein called CD70 on tumor cells and to better reach the brain. The main goals are to see if the treatment is safe and …

This early-phase study tests a modified herpes virus designed to attack brain tumor cells directly. The virus is injected into the tumor, and some participants also receive a drug to boost the immune response. The main goal is to find the safest dose and see how the body reacts. …

This early-phase study tests two immunotherapy drugs (nivolumab and ipilimumab) given before surgery in people with recurrent glioblastoma, an aggressive brain cancer. The goal is to see if the drugs are safe and how they affect immune cells in the tumor. About 63 participants wi…

This phase 2 study tests whether adding the antiviral drug valganciclovir to standard treatment can help people with glioblastoma, an aggressive brain cancer. The drug targets cytomegalovirus (CMV), which is often found in these tumors and may make them more aggressive. About 220…

This early-phase study tests whether adding high-dose vitamin C and an iron-based drug (ferumoxytol) to standard radiation and chemotherapy can help control glioblastoma, an aggressive brain tumor. About 17 adults with newly diagnosed glioblastoma will receive these added treatme…

This study was designed to see if a diet low in certain amino acids (cysteine and methionine) changes how the body and brain tumor cells work in people with recurrent glioma. Up to 30 participants would have been randomly assigned to either a regular diet or the special diet for …