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New drug combo shows promise against deadly brain cancers

NCT ID NCT06806228

First seen Nov 18, 2025 · Last updated Jun 19, 2026 · Updated 26 times

Summary

This early-phase study tests whether adding the experimental drug S-Gboxin to standard radiation and chemotherapy can help people with glioblastoma or diffuse midline glioma, two aggressive brain cancers. Ten participants whose tumors have returned or worsened will receive the combination and be monitored with brain scans and survival tracking. The goal is to see if S-Gboxin can shrink tumors or improve outcomes, while checking for side effects.

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Contacts and locations

Locations

  • Kazakh Institute of Oncology and Radiology

    Almaty, 490 078, Kazakhstan

  • National Cancer Institute

    Kyiv, 33/43, Ukraine

  • Tbilisi Cancer Centre

    Tbilisi, 0198, Georgia

Conditions

The condition(s) this trial relates to.

diffuse intrinsic pontine glioma diffuse midline glioma, H3 K27M-mutant giant cell glioblastoma glioblastoma glioma susceptibility 1 gliosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.