GLIOBLASTOMA MULTIFORME

This phase III trial is testing whether delivering the drug bevacizumab (Avastin) directly to the brain through a catheter, along with standard chemo and radiation, can help people with newly diagnosed glioblastoma live longer. The study will enroll 432 adults with this aggressiv…

This early-stage trial is testing whether combining a chemotherapy wafer placed in the brain during surgery with an immunotherapy drug and standard radiation (with or without another chemo pill) is safe and feasible for people with newly-diagnosed glioblastoma. About 50 adults wh…

This early-phase study tests the drug lorlatinib in children and young adults (ages 1 to 21) with newly diagnosed high-grade glioma, a fast-growing brain tumor, that has a specific genetic change (ALK or ROS1 fusion). The goal is to see if the drug can shrink or control the tumor…

This phase 2 trial is testing whether chemotherapy alone (temozolomide) works as well as the standard combination of chemotherapy plus radiation for elderly and frail patients with newly diagnosed glioblastoma. The study aims to enroll 107 patients aged 65 and older with poor per…

This study tests a gene therapy (HSV-tk) plus valacyclovir alongside radiation and chemotherapy for people newly diagnosed with glioblastoma or anaplastic astrocytoma. The goal is to see if this combination improves survival. About 62 participants will receive the gene therapy in…

This pilot study tests whether adding APG-157 (a pastille dissolved in the mouth) to standard bevacizumab can help people with recurrent high-grade glioma. About 30 participants will take APG-157 three times daily while continuing bevacizumab. The study tracks survival, tumor res…

This early-stage trial tests whether a specially engineered herpes virus (G207) is safe to inject directly into the brain tumors of children whose cancer has returned. Up to 24 children aged 3 to 21 will receive the virus, and some will also get a low dose of radiation to help th…

This study tests whether giving the drug bevacizumab (Avastin) directly into the brain's arteries, repeated over time, is safe and effective for people with recurrent glioblastoma or anaplastic astrocytoma. The approach aims to bypass the blood-brain barrier, which often blocks s…

This early-phase trial is testing a radioactive drug called 131I-TLX101, given alongside standard care, for people newly diagnosed with glioblastoma, an aggressive brain cancer. The study involves 12 participants and aims to find the safest dose and check for side effects. It is …

This early study tests whether using focused ultrasound (NaviFUS) to temporarily open the blood-brain barrier can help the drug Avastin work better against recurrent glioblastoma, an aggressive brain cancer. Ten adults whose cancer has returned after standard treatment will recei…

This study tests whether adding the drug tarlatamab to standard radiation therapy is safe for people with cancers that have a protein called DLL3, including melanoma, lung cancer, and glioblastoma. About 30 adults with advanced or returning cancers will receive tarlatamab infusio…

This study tests a gene therapy (HSV-tk) plus valacyclovir, along with radiation and chemotherapy, in people whose glioblastoma or high-grade astrocytoma has returned. The goal is to see if this combination can improve survival. About 62 participants will receive the treatment di…

This phase 2 trial tests a combination of a targeted cancer drug (cetuximab) given directly into the brain's blood vessels along with repeat radiation for people whose brain cancer has come back. The study includes 37 adults with specific types of aggressive brain tumors that ove…

This study tests a new approach for people with a recently removed glioblastoma (a fast-growing brain tumor). Doctors take some of the patient's own blood stem cells, add a protective gene (P140K MGMT) to them, and return them to the patient. This allows the use of higher doses o…

This study tests if using focused ultrasound (sound waves) can help the drug Avastin work better for people with recurrent glioblastoma, an aggressive brain cancer. About 32 adults will either get Avastin alone or Avastin plus the ultrasound treatment. The goal is to see if the c…

This early-phase trial tests a new treatment for adults with a returning type of brain cancer called glioblastoma. The therapy uses the patient's own immune cells (T cells) that are genetically modified to recognize and attack cancer cells that carry a protein called GPC3. The mo…

This early study tests if a piece of belly tissue placed in the brain during surgery can safely bypass the blood-brain barrier in people with recurrent glioblastoma, an aggressive brain cancer. Ten adults will be followed for 6 months to check for side effects like rapid tumor gr…

This study tests whether giving two drugs (cetuximab and bevacizumab) directly into the brain's blood vessels each month is safe and can shrink tumors or slow their growth. It includes children and young adults under 22 with certain types of brain tumors that have come back or no…

This trial tests a new way to treat glioblastoma, an aggressive brain cancer. A device implanted in the skull uses ultrasound to temporarily open the blood-brain barrier, allowing immune-boosting drugs to reach the tumor. The study involves 25 adults with newly diagnosed glioblas…

This early-stage study tests whether a new type of immune cell therapy (CAR T-cells) is safe for people with glioblastoma, a fast-growing brain cancer that has come back or not responded to standard treatment. The therapy is given directly into the fluid around the brain. The mai…

This pilot study tests a new approach called sonodynamic therapy for people with recurrent glioblastoma, a type of brain cancer that has come back. The treatment combines an investigational drug (5-ALA) with low-intensity focused ultrasound to target and damage tumor cells before…

This early-phase pilot study is testing whether combining the immunotherapy drug atezolizumab with targeted radiation before surgery can help treat newly diagnosed glioblastoma, an aggressive brain cancer. Twelve patients will receive two weeks of radiation plus two doses of atez…

This early study tests a device called TheraSphere GBM in 36 people whose glioblastoma has come back after prior treatment. The device delivers tiny radioactive beads directly to the tumor to try to control it. The main goal is to check if the procedure is safe, not yet whether i…

This study tests a nasal spray drug called NEO100 (perillyl alcohol) in people with aggressive brain tumors (grade III or IV gliomas) that have come back or worsened. The trial has two phases: first to find the safest dose, then to see if it helps patients live longer. About 49 p…

This early-phase trial tests a combination of two treatments for people with glioblastoma and other aggressive brain cancers. One treatment is a genetically modified herpes virus (M032) that is injected into the tumor to stimulate the immune system. The other is pembrolizumab (Ke…

This pilot trial tests a portable, wearable device that delivers low-intensity magnetic therapy to people with newly diagnosed glioblastoma, an aggressive brain cancer. The study will enroll 30 adults who have had surgery and are able to receive standard radiotherapy. The main go…

This study tests a new surgical technique for people with glioblastoma, an aggressive brain cancer. Surgeons place a piece of the patient's own tissue (from the scalp or skull lining) into the area where the tumor was removed. This tissue flap may help bypass the blood-brain barr…

This early-phase trial tests a personalized vaccine called Tamavaq NeoVaccine in 29 adults with newly diagnosed glioma, a type of brain cancer. The vaccine is custom-made for each patient using AI and quantum mechanics to target unique cancer markers. The main goal is to check if…

This study tests an experimental drug called LMP744 in 40 adults whose glioblastoma (a serious brain cancer) has returned after standard treatment. The drug is given through a vein for 5 days each month for up to a year. The goal is to see if it can shrink tumors or slow their gr…

This study tests whether a ketogenic (high-fat, low-carb) diet can help people with newly diagnosed glioblastoma, an aggressive brain cancer, live longer. About 170 adults will be randomly assigned to either a ketogenic diet or standard dietary guidance, while all receive standar…

This program provides gallium maltolate (GaM) to adults aged 18 and older with glioblastoma that has returned or is not responding to standard treatments. The goal is to offer a possible treatment option when no others are available. Patients must be able to swallow capsules and …

This early-phase study tests a new approach for people with recurrent high-grade astrocytomas, a type of aggressive brain cancer. Participants will receive a special virus injected into the tumor cavity during surgery, followed by targeted radiation. The main goal is to find the …

This study tests whether adding the drug ruxolitinib to standard treatment (radiation and temozolomide) helps people with newly diagnosed glioblastoma live longer. About 190 adults will be randomly assigned to receive either the standard treatment alone or standard treatment plus…

This early-phase study tests a new treatment for aggressive brain tumors (glioblastoma and pediatric high-grade gliomas). The therapy uses a patient's own immune cells, modified to target a protein called CD70 on tumor cells and to better reach the brain. The main goals are to ch…

This study tests whether adding two different drug combinations after radiation can help children and young adults (up to age 21) with high-grade gliomas, including DIPG, live longer. One group receives ribociclib plus everolimus; another gets ribociclib plus temozolomide. The go…

This study tests whether combining an immunotherapy drug (pembrolizumab) with targeted radiation before surgery is safe and can help people with recurrent glioblastoma, an aggressive brain cancer. About 10 adults whose tumor has returned after prior treatment will receive this co…

This study tests a new technique called sonobiopsy that uses focused ultrasound to release DNA from brain tumors into the bloodstream, making it easier to detect and analyze the tumor's genetic makeup through a simple blood test. The goal is to improve diagnosis and treatment pla…

This study uses genetic testing of brain tumors from children, adolescents, and young adults (ages 1 to 39) with newly diagnosed high-grade glioma, including DIPG. The goal is to identify specific genetic changes in each tumor and then see if patients can join a treatment trial t…

This study tests a special pair of magnifying glasses (loupes) that help surgeons see glowing brain tumor tissue during surgery. The device uses a fluorescent dye to make tumor cells light up, so the surgeon can remove more of the tumor while sparing healthy brain. The trial will…

This study collects and preserves glioblastoma tissue from 120 patients during standard surgery, along with blood samples. Researchers will analyze tissue from different tumor regions to understand its structure and genetics. The goal is to learn more about how glioblastoma works…

This study is developing an AI-powered blood test to detect several cancers early and monitor how well treatments are working. Researchers will analyze blood samples from 6,000 adults with or without cancer to find unique RNA markers in platelets and immune cells. The goal is to …

This study is testing a new type of MRI and PET scan to better understand how brain tumors use energy. About 50 adults with glioblastoma will have special scans before surgery, and the results will be compared to tumor tissue samples. The goal is to improve imaging, not to treat …

This study tests whether adding a special PET scan (FET-PET) to standard MRI can better guide surgery and radiation for glioblastoma, the most aggressive brain tumor. About 189 adults with a single tumor will be randomly assigned to have treatment planning based on MRI alone or M…

This study tests whether special MRI scans can spot low-oxygen (hypoxic) areas in glioblastoma, an aggressive brain cancer. Twenty adults with suspected glioblastoma will get two types of MRI scans to map these areas. The goal is to see if these scans can help doctors deliver mor…

This study looks at whether measuring two proteins (VEGF and MMP) in blood and urine can help predict if a glioblastoma brain tumor will come back within a year after radiation therapy. About 200 adults with this type of brain tumor will provide samples before, during, and after …