GLIOBLASTOMA MULTIFORME

This study tested a new surgical technique in 12 patients with newly diagnosed glioblastoma, an aggressive brain cancer. Surgeons placed a tissue flap from the scalp into the brain tumor cavity to bypass the blood-brain barrier, which normally blocks many treatments. The main goa…

This pilot study tested a device called NaviFUS that uses focused ultrasound to temporarily open the blood-brain barrier, combined with the drug bevacizumab (Avastin), in 6 patients with recurrent glioblastoma (a type of brain cancer). The goal was to see if the combination is sa…

This early-phase study tested a new drug called tinostamustine in 10 people with a fast-growing brain cancer (glioblastoma) that has a specific genetic marker (unmethylated MGMT). The goal was to see if the drug is safe and to find the best dose when given after standard treatmen…

This study tested a drug called pamiparib, given with radiation therapy, for people with a fast-growing brain cancer called glioblastoma. It included 50 patients, some newly diagnosed and some whose cancer had come back. The goal was to see how much drug reaches the tumor and whe…

This study tested a new drug called VAL-083 combined with standard radiation for people with a fast-growing brain cancer (glioblastoma) that has a specific genetic marker making it harder to treat. The goal was to find the safest dose and see if the drug helps shrink tumors. The …

This study tested a personalized vaccine made from a patient's own tumor cells and immune cells (dendritic cells) for people with newly diagnosed glioblastoma, an aggressive brain cancer. The goal was to see if the vaccine is safe and can help delay tumor growth. 76 participants …

This early-phase study tested an experimental drug called INCB7839 in 13 children whose high-grade gliomas (aggressive brain tumors) had come back or worsened after standard treatment. The main goals were to find a safe dose and check for side effects. The drug works by blocking …

This study tested giving a second round of radiation to people whose glioblastoma (a fast-growing brain tumor) came back after standard treatment. Seventeen adults aged 18 to 50 received daily radiation for 2-3 weeks. The goal was to find the safest highest dose and see how it af…

This study looked at whether a modified Atkins diet combined with short-term fasting is possible for people with glioblastoma, an aggressive brain cancer. Twenty-five patients who had already completed standard treatment tried the diet for 8 weeks. The main goal was to see if the…

This study tested a device called Optune, which delivers electric fields to the brain, alongside radiation and chemotherapy for people newly diagnosed with glioblastoma, an aggressive brain cancer. About 981 adults took part. The goal was to see if adding Optune to standard treat…

This early-phase study tested whether adding a drug called chlorpromazine (an older medication used for mental health) to standard brain cancer treatment is safe for people newly diagnosed with glioblastoma, a serious brain tumor. Ten adults took part to find the best dose and ch…

This study tested whether a special type of PET/MRI scan using a radioactive tracer called FET can better map glioblastoma brain tumors after surgery compared to standard MRI. The goal was to see if this could help doctors plan radiation therapy more accurately. Eleven adults who…

This study tested whether a PET/CT scan using 11C-methionine, a radioactive amino acid, could improve radiotherapy planning for people with glioblastoma (a fast-growing brain cancer) whose tumors worsen soon after surgery. Thirty-three patients received the scan before starting c…