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New scan may sharpen radiation for Fast-Growing brain cancers

NCT ID NCT05608395

Knowledge-focused Sponsor: Masaryk Memorial Cancer Institute Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed Phase 2 trial tested whether a special PET/CT scan using 11C-methionine could help doctors better plan radiation therapy for people with glioblastoma, the most common and aggressive brain cancer. The study focused on patients whose tumors grew back quickly after surgery (rapid early progression). 33 participants received the scan, and their radiation plans were adjusted based on the results. The goal was to see if this approach could improve how long patients lived without their cancer worsening.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
11C-methionine (a radioactive amino acid used in PET/CT scans)
What this could lead to
If successful, this approach could help doctors create more precise radiotherapy plans for glioblastoma patients whose tumors grow back quickly after surgery, potentially improving their outcomes.
What could go wrong
This is a small, early-phase study with only 33 participants, and it compares results to historical data rather than a control group. The benefit of adjusting radiotherapy based on this scan is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

33 people

The number who actually took part.

Started

Dec 2020

Finished

Jun 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. The subject is a person with a histologically proven diagnosis of glioblastoma (GB) according to WHO 2016. 2. The subject is male or female, aged 18 years or older. 3. Performance status (PS) according to ECOG (Eastern Cooperative Oncology Group) 0-2. 4. Healed operation wound. 5. Post-operative MR up to 72 hours. 6. Indication to adjuvant chemoradiotherapy. 7. Patient has to express his/her informed consent and sign the form before the screening period. 8. Detected rapid early progression. 9. Patient must achieve following values of laboratory parameters in the peripheral blood during the screening period: 1. neutrophiles (total count) ≥1500/mm3 2. platelets (total count) ≥100 000/mm3 3. hemoglobin ≥ 9,0 g/dL 4. serum creatinin ≤1,5x of upper limit of normal, ULN 5. total bilirubin 1,5x ULN, unless documented Gilbert's syndrome, for which bilirubin ≤ 3x ULN is permitted 6. AST/ALT ≤3x ULN Exclusion Criteria: 1. Prior brain surgery. 2. Prior radiotherapy targeting brain. 3. The history of active/currently treated cancer (solid tumor); the exceptions are: non-melanoma skin cancer, in situ bladder carcinoma, in situ gastric cancer, in situ colorectal carcinoma, in situ cervical carcinoma, in situ breast cancer. 4. Any systemic disease or health condition that might posses a risk at anticancer therapy and imaging techniques (MRI, MET PET). 5. Patients must not have substance abuse disorders that would interfere with cooperation with the requirements of the trial. 6. Patients must not have any evidence of ongoing (active) infection (HIV, hepatitis A, B, C). 7. Pregnant and/or breastfeeding women. 8. Patient who disagree and refuses to sign an Informed consent.

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Conditions

The condition(s) this trial relates to.

glioblastoma glioma susceptibility 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Glioblastoma multiforme

Contacts and locations

Locations

  • Masaryk Memorial Cancer Institute

    Brno, Czech Republic, 65653, Czechia

More trials for these conditions

Other studies related to the condition(s) this trial covers.