GLIOBLASTOMA MULTIFORME

This early-phase study tests a new approach for people with recurrent high-grade brain tumors (astrocytomas). It combines a virus-based gene therapy with targeted radiation during surgery. The main goal is to find the safest dose and see if it boosts the immune system against the…

This early-stage study tests a device that uses sound waves to help a standard cancer drug reach the brain more effectively in people with recurrent glioblastoma, an aggressive brain tumor. Ten participants will receive the drug bevacizumab along with focused ultrasound to see if…

This study tests whether chemotherapy alone works as well as the standard combination of chemotherapy and radiation for elderly or frail patients with a new glioblastoma diagnosis. About 107 participants will be randomly assigned to one of two treatment groups. The goal is to fin…

This study tests if giving two cancer drugs (cetuximab and bevacizumab) directly into the brain's arteries each month is safe and works for children and young adults under 22 whose brain tumors have come back or not responded to treatment. About 20 participants will receive the d…

This early-stage trial tests whether a specially engineered virus, G207, is safe for children with cerebellar brain tumors that have come back or not responded to standard treatments. The virus is injected directly into the tumor, and a low dose of radiation is given to help the …

This pilot study is for people with recurrent glioblastoma, a serious brain cancer that has come back. It tests a new approach called sonodynamic therapy, which combines an investigational drug (5-ALA) with focused ultrasound waves guided by a brain-mapping system. The goal is to…

This study tests a new approach for people with a fast-growing brain cancer called glioblastoma. Researchers take a patient's own blood stem cells, add a protective gene, and return them so the bone marrow can survive higher doses of chemotherapy. The goal is to kill more cancer …

This study tests the safety of a device called TheraSphere GBM for people whose glioblastoma brain tumor has come back. About 36 adults will receive the treatment to see if it is safe and technically possible. The goal is to find a new way to control the disease when standard tre…

This early-phase trial is testing whether combining a precise type of radiation (FSRT) with an immunotherapy drug (atezolizumab) can help people with a fast-growing brain tumor called glioblastoma. Twelve newly diagnosed patients will receive the combination for two weeks before …

This early-stage study tests whether a new treatment using specially engineered immune cells (CAR T-cells) is safe for people with glioblastoma, a fast-growing brain cancer that has come back. About 36 participants will receive the cells directly into the fluid around the brain. …

This study tests whether adding the drug ruxolitinib to standard treatment (radiation and temozolomide) helps people with newly diagnosed glioblastoma live longer. About 190 adults will be randomly assigned to receive either the standard treatment alone or standard treatment plus…

This study looks at the genetic makeup of high-grade brain tumors in children, teens, and young adults (ages 1 to 39) who are newly diagnosed. The goal is to find specific genetic changes that could make them eligible for future treatment studies. No treatment is given in this st…

This study is collecting blood and urine samples from 200 adults with glioblastoma (a serious brain tumor) who are receiving radiation therapy. Researchers want to see if levels of two proteins, VEGF and MMP, can help predict whether the tumor will come back within one year. The …