Could skipping radiation help elderly brain cancer patients live longer with fewer side effects?
NCT ID NCT04765514
First seen Feb 16, 2026 · Last updated Jun 23, 2026 · Updated 19 times
Summary
This phase 2 trial is testing whether chemotherapy alone (temozolomide) works as well as the standard combination of chemotherapy plus radiation for elderly and frail patients with newly diagnosed glioblastoma. The study aims to enroll 107 patients aged 65 and older with poor performance status. If chemotherapy alone proves non-inferior, it could offer a less toxic and more convenient treatment option.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Arthur J.E. Child Comprehensive Cancer Center (formerly Tom Baker Cancer Centre)
TERMINATEDCalgary, Alberta, Canada
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Cross Cancer Institute
RECRUITINGEdmonton, Alberta, T6G 1Z2, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Temozolomide (chemotherapy)
What this could lead to
If successful, this could show that chemotherapy alone is a safe and effective option for elderly glioblastoma patients, avoiding the added side effects of radiation.
What could go wrong
This is a small, early-phase trial (107 people) comparing two treatments, not testing a new drug. It may not prove that chemotherapy alone is better or equal, and results may not apply to all patients.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.