DIABETES MELLITUS, TYPE 1

This study tested a smart insulin pen and continuous glucose monitor system (Smart MDI) against standard insulin injections with glucose monitoring in 179 people with type 1 diabetes. The goal was to see if the smart system helps keep blood sugar in a healthy range more effective…

This study tested a new fast-acting insulin (faster aspart) against a standard insulin (NovoRapid) in 331 adults with type 1 or type 2 diabetes. Both groups also took long-acting insulin (degludec) and could use metformin. The goal was to see if the new insulin works better at co…

This study tested an automated insulin delivery system (a smart pump) in 15 adults with type 1 or type 2 diabetes who also had advanced kidney disease or were on dialysis. Participants used the system for 8 weeks, then switched to their usual care for another 8 weeks. The goal wa…

This study looked at how quickly a fast-acting insulin (faster aspart) enters the blood in 23 Chinese adults with type 1 or type 2 diabetes. Participants received one injection of the test insulin and one of the standard insulin NovoRapid, in random order. Blood samples were take…

This study tested whether personalized text messages can help young adults with type 1 diabetes feel more confident managing their condition as they switch from pediatric to adult care. About 234 participants received either usual care or extra text-based support. The goal was to…

This study tested whether verapamil, a drug usually used for high blood pressure, could help preserve the body's ability to make insulin in people newly diagnosed with type 1 diabetes. 136 adults took either verapamil or a placebo daily for 12 months. The main goal was to measure…

This study tested whether taking high doses of omega-3 fatty acids (fish oil) and vitamin D together is safe and might help people with type 1 diabetes keep making some of their own insulin. It included 27 people aged 6 to 65, both newly diagnosed and those living with diabetes f…

This study tested a new medicine called dasiglucagon against the standard glucagon for treating severe low blood sugar in 38 Asian adults and Japanese adolescents with type 1 diabetes. Both medicines are injected to quickly raise blood sugar during emergencies. The goal was to se…

This study looked at the safety and effectiveness of Fiasp, a fast-acting mealtime insulin, in 42 adults with type 1 or type 2 diabetes. Participants used Fiasp as their doctor prescribed for about 6 months. The main goal was to track any side effects, including serious ones and …

This study tested a program to help teens and young adults (ages 16-25) with type 1 diabetes better manage their blood sugar. The program focused on supporting their independence and confidence in daily diabetes care. 113 participants joined the study to see if this approach coul…

This study looked at whether using a smart insulin pen (NovoPen 6) with two insulins (Tresiba and Fiasp) helps people with type 1 diabetes achieve better blood sugar levels. Over 400 adults took part for about 9-11 months, using the pen to track doses and a mobile app to see thei…

This study tested whether the Omnipod 5 insulin pump, which automatically adjusts insulin, works better than multiple daily injections for managing type 1 diabetes. 189 children and adults used either the pump or injections, along with a continuous glucose monitor. The main goal …

This study tested a fully automated system that delivers both insulin and glucagon to manage blood sugar in adults with type 1 diabetes. Over 12 months, 243 participants used either this dual-hormone system or standard care. The goal was to see if the new system helps people spen…

This study tested whether combining two immune therapies—abatacept (injected weekly) and nasal insulin (sprayed daily then twice weekly)—can help preserve the pancreas's ability to make insulin in people recently diagnosed with type 1 diabetes. 68 participants aged 6 to 21 took p…

This study tested whether a newer insulin (glargine) is safer and better at controlling blood sugar than standard human insulin in 400 youth aged 7-25 with type 1 diabetes living in low-resource settings. Participants used continuous glucose monitors to track their levels over 6-…

This study looked at whether real-time remote continuous glucose monitoring (CGM) and secure text messaging could help teens aged 13-18 with poorly controlled type 1 diabetes improve their blood sugar levels. Twenty participants wore a CGM that shared their glucose readings with …

This early study tested a new treatment called Stem Cell Educator therapy in 13 adults with type 1 diabetes. The goal was to see if the therapy is safe and possible to do. The treatment uses a device to 'educate' the patient's own immune cells outside the body, then returns them,…

This study tested whether a continuous glucose monitor (CGM)-based advisory system helps adults with type 1 diabetes manage their blood sugar better than standard sensor-augmented therapy. 88 participants used the system, which also considered their personal habits and feelings t…

This early-stage trial tested whether a new drug called R-5280 is safe and tolerable for children aged 11 to 17 who were recently diagnosed with type 1 diabetes. Nine participants took the drug or a placebo, and researchers monitored side effects and blood sugar levels over 12 we…

This study looked at how aerobic and resistance exercise impact blood sugar levels after eating in children and teens (ages 10-18) with type 1 diabetes. 49 participants completed the trial. The goal was to find which type of exercise helps manage blood sugar better after meals.

This study tested a new insulin delivery system called Tandem Freedom in 10 adults with type 1 diabetes. Participants used their usual system for one week at home, then switched to Tandem Freedom during a supervised hotel stay. The main goal was to check for severe low blood suga…

This study tested a new system called Tandem Freedom in 10 adults with type 1 diabetes who already use Control-IQ technology. Participants used their usual system at home for a week, then switched to Tandem Freedom during a supervised hotel stay. The goal was to check safety by c…

This early-stage study tested a new medicine, NNC0363-1063, in 117 healthy volunteers and people with type 1 diabetes. The goal was to check safety, how the body processes the drug, and its effect on blood sugar. This is not a cure; it aims to help control diabetes with ongoing t…

This study tested a new insulin called icodec that is injected just once a week, compared to a standard daily insulin (degludec), in 582 adults with type 1 diabetes. Both groups also used mealtime insulin. The goal was to see if the weekly insulin controls blood sugar as well as …

This study tested whether using a continuous glucose monitor (CGM) in the hospital can help keep blood sugar levels in a safe range for people with type 1 or high-risk type 2 diabetes. 157 patients wore a wireless CGM that sent real-time glucose readings to a care team, who then …

This study tested a new fast-acting insulin (NNC0471-0119) in 43 adults with type 1 diabetes who use an insulin pump. Researchers measured how quickly the insulin entered the bloodstream and lowered blood sugar, comparing it to standard insulin aspart. The goal was to see if the …

This study tested whether a 6-month online mindfulness program could help adults with type 1 or type 2 diabetes lower their blood sugar and stress. About 309 people with high stress and uncontrolled diabetes took part. Half received mindfulness training, the other half stress man…

This study looked at how easy and convenient the DuraTouch® device is for people with type 1 or type 2 diabetes. 128 participants used the device for about 12 weeks and rated their satisfaction. The goal was to see if the device makes daily diabetes care simpler and more convenie…

This study looked at 76 children with type 1 diabetes to compare two methods of calculating insulin doses for meals. The goal was to see which method better controls blood sugar spikes after eating. Researchers measured blood sugar levels after meals to find the most effective do…

This study looked at 55 adults with diabetes who have an allergy to insulin. The goal was to create a better way to diagnose this allergy and understand why it happens. Researchers tested skin reactions to insulin and studied the immune system and genetics of participants to find…

This study looked at whether eating fewer carbohydrates could help people with type 1 diabetes become more sensitive to insulin and improve blood vessel health. Fourteen adults on insulin pumps tried both a low-carb diet and a standard diet for one week each. The results showed n…

This study looked at how different types of exercise (short bursts of intense cycling vs. steady moderate cycling) and timing relative to meals affect blood sugar in physically active adults with type 1 diabetes. Twenty-one participants completed four exercise sessions while thei…

This study tested a new smartphone-based tool called PEPPER that gives personalized insulin dose advice to people with Type 1 diabetes. The system uses artificial intelligence to learn from each person's past data and includes safety alerts for low blood sugar. Eight adults used …

This completed study tested if having a Diabetes Navigator (a personal guide) helps people with type 1 diabetes use advanced technology like continuous glucose monitors and insulin pumps more effectively. 148 participants were randomly assigned to get navigator support or standar…

This study followed 87 active adults with type 1 diabetes who use automated insulin pumps and exercise at least twice a week. Researchers monitored their blood sugar levels before, during, and after exercise in real-life settings. The goal was to understand how physical activity …

This study looked at whether viral infections in pregnant women with diabetes might increase the chance of their babies being born with heart defects. Researchers analyzed blood and stool samples from 114 women to detect viruses and immune responses. The goal was to gather initia…

This study tested a new biosensor that measures blood glucose every 10 minutes in people with type 1 diabetes who use an insulin pump. The sensor was compared to standard continuous glucose monitors during daily activities like meals and exercise. The goal was to see if the new s…

This study looked at how often sleep apnea occurs in adults with type 1 diabetes. Researchers monitored 53 participants overnight with sleep tests and continuous glucose monitors. The goal was to find out how many have moderate-to-severe sleep apnea and how it relates to blood su…