DIABETES MELLITUS, TYPE 1

This study tests whether transplanting insulin-producing islet cells from deceased donors can help people with brittle type 1 diabetes achieve safer blood sugar levels without needing insulin shots. Up to 20 adults aged 18-70 will receive the cells through a vein and be monitored…

This study is testing whether giving repeated doses of the BCG vaccine (traditionally used for tuberculosis) can help children aged 8 to 18 with type 1 diabetes. The goal is to see if it improves blood sugar control and reduces insulin needs. 150 participants will be followed to …

This study tests whether adding a gut hormone called gastrin to an islet cell transplant can help people with hard-to-control type 1 diabetes produce their own insulin and improve blood sugar. About 20 adults aged 18-68 with unstable blood sugar will receive donor islet cells plu…

This study tests whether baricitinib, a pill, can help preserve the body's remaining insulin-producing cells in children and young adults (ages 1 to 36) recently diagnosed with type 1 diabetes. Participants will take baricitinib or a placebo for about 60 weeks. The goal is to see…

This study looks at whether doing aerobic exercise before breakfast (fasted) or after breakfast (fed) is better for people with type 1 diabetes. Twenty adults with type 1 diabetes will train for 12 weeks, and researchers will track their insulin use and blood sugar levels. The go…

This study tests whether strictly avoiding low blood sugar (hypoglycemia) can help adults with type 1 diabetes regain the ability to feel symptoms of low blood sugar. About 324 participants with impaired awareness of hypoglycemia will use a closed-loop insulin system and educatio…

This study tests whether an online training and peer support platform, called Support-t, can help teenagers with type 1 diabetes prepare for the move from pediatric to adult healthcare. About 200 teens aged 14-16 will either receive usual care or also get access to the platform. …

This pilot study will test whether a hybrid closed-loop insulin pump (a 'smart' pump that adjusts insulin automatically) can help 40 adults with poorly controlled type 1 diabetes (A1c over 8.5%) from diverse backgrounds in Los Angeles. The goal is to see if it's possible to run a…

This study looks at how well the Control-IQ insulin pump system works for people with type 1 diabetes in everyday life. About 350 people aged 6 and older in France will use the system for 12 months. Researchers will track safety events like severe low blood sugar and diabetic ket…

This study tests a new stem cell treatment called VX-880 for people with type 1 diabetes who have dangerous low blood sugar episodes. The goal is to see if a single infusion can help the body make its own insulin again, reducing or eliminating the need for insulin shots. About 52…

This early-phase study tests a new treatment called OPF-310, which uses pig islet cells (the cells that make insulin) placed inside tiny capsules. The goal is to see if transplanting these cells is safe and can help adults with unstable type 1 diabetes who still have dangerous lo…

This early-stage study is testing a new insulin called NNC0363-1063 in people with type 1 diabetes. Researchers want to see how it interacts with a non-glucose carbohydrate found in food and drink, and whether taking them together is safe. About 36 adults aged 18-64 will receive …

This study tests a new automated insulin delivery system (the Medtrum TouchCare Nano with APGO algorithm) in 200 adults with type 1 diabetes. The system automatically adjusts insulin based on blood sugar levels, aiming to keep glucose in a healthy range. Researchers will measure …

This study tests whether hybrid closed loop insulin pumps (smart pumps) can help adults with type 1 diabetes from underserved communities better control their blood sugar. About 140 participants will be randomly assigned to use one of three FDA-approved pump systems or standard i…

This study looks at whether inhaled insulin (Afrezza) is safer than standard pump insulin for preventing low blood sugar during exercise after a meal in adults with type 1 diabetes. About 30 people aged 18-65 who use a Tandem pump with Control-IQ will complete three exercise sess…

This study tests whether a combination of special immune cells (Tregs) and an antibody drug (rituximab) can delay or prevent type 1 diabetes in children aged 6–16 who are at high risk but still produce insulin normally. About 150 participants will be randomly assigned to one of f…

This study tests whether a very-low-carbohydrate ketogenic diet can safely improve blood sugar control in adults with type 1 diabetes. Researchers will monitor blood sugar levels, insulin needs, and muscle insulin sensitivity in 58 participants over the study period. The goal is …

This study looks at how well a new insulin called insulin icodec controls blood sugar in people with type 1 diabetes who have never used it before. About 245 participants will take the insulin as prescribed by their doctor and be followed for 22 to 30 weeks. The main goal is to s…

This study compares two ways of using laser treatment for proliferative diabetic retinopathy, a leading cause of blindness in working-age adults. Researchers will give 40 participants either a single laser session or multiple sessions to see which is safer and works better. The g…

This study is testing whether semaglutide, a drug already used for type 2 diabetes, can improve heart and kidney function in adults with type 1 diabetes. Researchers will measure artery stiffness and insulin sensitivity in 60 participants over time. The drug is not yet FDA-approv…

This early-stage study tests a new treatment called CELZ-201 for people recently diagnosed with type 1 diabetes. The treatment is given through an artery and aims to see if it is safe and can help control the disease. The study involves 18 adults aged 18-35 who were diagnosed wit…

This study tests an experimental drug called cadisegliatin, taken alongside insulin, to see if it can lower the number of dangerous low blood sugar events in adults with type 1 diabetes. About 150 participants will receive either the drug or a placebo for 26 weeks. The goal is to…

This study is for children with a rare form of type 1 diabetes caused by a genetic immune disorder. Doctors will first transplant umbilical cord blood stem cells to rebuild the immune system. Then, if the child is stable, they will receive islet cells (cells that make insulin) to…

This study tests a new device called the Eversense Gemini System, which helps people with diabetes check their blood sugar levels without finger sticks. About 80 adults with type 1 or type 2 diabetes will use the system to see how accurate and safe it is compared to standard moni…

This early-stage trial tests a new treatment called RGB-5088 for people with type 1 diabetes. It involves injecting special islet cells that can produce insulin, aiming to help the body control blood sugar better and prevent dangerous low blood sugar events. The study will includ…

This study helps 50 children (ages 6 to 17) with type 1 diabetes who have high blood sugar levels and come from low-income families. Participants will receive advanced insulin pumps and continuous glucose monitors with help from an insurance navigator. The goal is to see if using…

This study follows about 630 people with type 1 diabetes in Japan who are already prescribed Awiqli, a once-weekly insulin. Researchers will track side effects and blood sugar control over one year. The goal is to see how well the drug works in everyday medical practice, not to c…

This study looks at whether giving people with diabetes who are food insecure access to nutritious meals and education can reduce their food insecurity and improve health. About 160 hospitalized adults with type 1 or type 2 diabetes will be randomly assigned to receive either sta…

This study tests if a new insulin taken once a week (insulin icodec) controls blood sugar as well as a standard daily insulin (insulin glargine) in adults with type 1 diabetes. About 877 participants will use either weekly or daily insulin, plus rapid-acting insulin at meals, for…

This study tests new versions of an insulin pump set that can be worn longer, up to 7 days, for people with type 1 diabetes. About 20 adults who already use a Tandem pump and Dexcom CGM will try the new set at home. The goal is to see if the set works safely for a full week witho…

This study tests whether the drug sotagliflozin can slow kidney function loss in 150 people with type 1 diabetes and moderate to severe kidney disease. Participants will take either the drug or a placebo daily for 3 years, while following a plan to prevent a serious side effect c…

This study tests whether transplanting insulin-producing islet cells from deceased donors can help people with type 1 diabetes who have already had a kidney transplant. The goal is to achieve better blood sugar control without needing insulin shots. Ten participants aged 18 to 68…

This study tests whether baricitinib, an oral medication, can delay the start of clinical type 1 diabetes in children aged 1 to 36 months who are at high risk. About 150 participants will receive either baricitinib or a placebo for up to 5 years. The main goal is to see if the dr…

This study tests whether giving the COVID-19 vaccine to babies as young as 6 months old can lower their chance of developing type 1 diabetes. It involves over 2,200 children who have a high genetic risk for the disease. Half will get the vaccine, half a placebo, and researchers w…

This early study tests whether a type of talk therapy for insomnia (CBTi) can improve sleep, blood sugar control, and quality of life in adults with type 1 diabetes. Fifteen participants will either get 8 virtual therapy sessions or health education emails and calls. The study fo…

This early-stage study tests a new medicine called LY4057996 in healthy volunteers and people with type 1 or type 2 diabetes. The main goal is to see if the drug is safe and what side effects it may cause. The study will also measure how the drug moves through the body and its ef…

This study looks at whether watching animated films or reading storybooks can lower fear and anxiety in children ages 7-12 who have just been diagnosed with type 1 diabetes. About 64 children will take part, and researchers will measure their anxiety and fear levels using special…

This study tests a group-based psychological program called ACTnow for young adults (18-35) with type 1 diabetes who feel overwhelmed by their condition. The goal is to reduce diabetes distress and improve well-being. Participants attend six bi-weekly group sessions led by a psyc…

This study compares two virtual group programs—one focused on emotions, the other on problem-solving—to help adults with type 1 diabetes reduce diabetes distress. Participants who don't improve may get extra one-on-one sessions. The goal is to find better ways to support emotiona…

This study aims to understand how insulin sensitivity changes across the menstrual cycle in women with type 1 diabetes. Researchers will track 350 women's insulin needs, blood sugar levels, and cycle information to find patterns. The goal is to help women and their doctors better…

This study looks at whether ultrasound images of the fetal liver can help detect high insulin levels in babies of mothers with type 1 diabetes. Researchers will compare 60 pregnant women—some with diabetes and some healthy—to see if the liver texture differs. The goal is to bette…

This study checks if a substance in the blood called 1,5-anhydroglucitol can help measure how many insulin-producing cells children with type 1 diabetes still have. Researchers will compare levels in newly diagnosed children, those with long-term diabetes, and healthy volunteers.…

This study tests two experimental insulin formulas to see if they work faster than a standard insulin in adults with type 1 diabetes. Twenty participants will receive each insulin type during separate visits, and blood samples will be taken to measure how quickly the insulin is a…

This study aims to learn the step-by-step process that leads to type 1 diabetes by studying families where at least one member has the condition. Researchers will collect blood samples, medical history, and measurements from 4,000 participants over 10 years. The goal is to unders…

This study looks at how the menstrual cycle changes blood sugar and energy use in women with type 1 diabetes. Researchers will track 40 women over their cycles using a closed-loop insulin system. The goal is to understand when insulin needs change and how hormones affect glucose …