DIABETES MELLITUS, TYPE 1

This study tests the safety of a 14-day teplizumab treatment in 20 children under 8 who have stage 2 type 1 diabetes (early signs but no symptoms yet). The goal is to see if the drug is safe and how the body processes it, with the hope of delaying or preventing the disease from p…

This study looks at whether using a continuous glucose monitor (CGM) helps people with diabetes who are on dialysis keep their blood sugar in a healthy range. About 96 adults on either hemodialysis or peritoneal dialysis will be split into three groups: one using standard finger-…

This early-stage study tests the safety of a device called ENC-201-CED in 10 people with type 1 diabetes who are receiving a transplant of insulin-producing cells (islets). The device is placed under the skin to hold and protect the transplanted cells. The main goal is to see if …

This study tests whether a single infusion of stem cells from donated umbilical cord blood can safely preserve insulin-making cells in people recently diagnosed with type 1 diabetes. 60 adults aged 18-40 with new-onset diabetes will receive the cells and be monitored for a year. …

This study aimed to see if dulaglutide, a drug that helps control blood sugar, could also improve the function of small blood vessels in adults with type 1 diabetes. The trial planned to enroll 47 people aged 18-40 with type 1 diabetes for over 5 years. The study is currently sus…

This study tested a new treatment called SR-02, which involves implanting insulin-producing cells into the abdomen of adults with type 1 diabetes who experience dangerous low blood sugar episodes. The goal was to see if the implant is safe and can help the body produce its own in…

This study tests two experimental drugs (abrocitinib and ritlecitinib) to see if they can help preserve the body's ability to make insulin in people recently diagnosed with type 1 diabetes. The trial involves 78 participants aged 12 to 35 who were diagnosed within the last 100 da…

This study tests a family-based weight management program for youth with type 1 diabetes who are overweight or obese, along with one of their parents who is also overweight. The program is adapted from a proven treatment and delivered in a hybrid format. The goal is to help both …

This study tests the safety of transplanting donor islet cells into people with difficult-to-control type 1 diabetes. The goal is to see if the cells can help stabilize blood sugar and reduce the need for insulin injections. Participants also receive anti-rejection drugs to prote…

This study looks at the long-term safety of teplizumab, a drug that may help control type 1 diabetes. It follows 188 children and teens who already completed the main PROTECT study. Researchers will monitor side effects and diabetes control for an additional 42 months. The goal i…

This study aimed to test whether a combination of four drugs (anti-thymocyte globulin, low-dose interleukin-2, adalimumab, and exenatide) could help people newly diagnosed with type 1 diabetes keep making their own insulin. The trial planned to enroll adults aged 18-35 within 120…

This study tests a program called Share plus for adults aged 60+ with type 1 diabetes and their care partners. The goal is to see if sharing continuous glucose monitor data helps improve blood sugar levels and reduce diabetes-related stress. About 168 participants will be followe…

This study tests whether using a continuous glucose monitor (CGM) with the help of a Patient Navigator can improve diabetes management and quality of life for people with type 1 diabetes. The study includes 150 participants aged 14 to 64 who have had serious diabetes complication…

This early-stage study tests a new drug, NNC0194-0499, in 96 adults with type 1 diabetes. The goal is to see if adding this drug, alone or with semaglutide, helps keep blood sugar in a healthy range better than placebo. All participants continue their usual insulin. The study las…

This study tests whether taking metformin daily during early pregnancy can prevent preeclampsia and other high blood pressure disorders in women with type 1 diabetes. About 60 pregnant women will receive either metformin or usual care starting before 20 weeks. The goal is to see …

This study tests a treatment called Diamyd® in children aged 8 to 17 who are at high risk for type 1 diabetes. The goal is to see if giving the drug directly into lymph nodes is safe and can prevent or delay the disease. Only 5 children with specific genetic markers are taking pa…

This study tests whether a program that combines a smartphone app with face-to-face therapy sessions can improve psychological well-being in children and adolescents with type 1 diabetes. About 122 young participants will use the app and attend therapy to learn skills for managin…

This study tests a 6-month program called Type 1 Together for teens aged 12-17 with type 1 diabetes who don't use a continuous glucose monitor (CGM) regularly. Participants get monthly meetings with a diabetes expert, educational app resources, and a mentor family to encourage co…

This study tests whether virtual peer groups can help Latinx teenagers (ages 13-17) with type 1 diabetes use insulin pumps and continuous glucose monitors more often. The program, called DREAM, was developed with input from teens, families, and doctors. Researchers will check if …

This study looks at how repeated low blood sugar (hypoglycemia) changes the way the brain uses glucose in people with type 1 diabetes. Researchers will use brain scans to measure these changes in 50 adults who have normal awareness of low blood sugar. The goal is to understand wh…

This study looks at how people with type 1 diabetes age, focusing on their physical and mental abilities compared to those without diabetes. Researchers will follow 400 adults aged 65 and older to find out what helps them stay healthy as they get older. The goal is to learn more …

This study looks at whether adding mental health support to regular type 1 diabetes care can improve both mood and blood sugar levels. About 80 adults will fill out online surveys every six months for 18 months. Some will also have at least one talk session with a behavioral heal…