DIABETES MELLITUS, TYPE 1

This is an early safety study testing a new device called ENC-201-CED. The device is designed to hold and protect insulin-producing islet cells after they are transplanted under the skin of people with Type 1 diabetes. The main goal is to see if the device is safe and well-tolera…

This study is testing whether using a continuous glucose monitor (CGM) can help diabetic patients on dialysis better manage their blood sugar levels. It compares three groups: standard finger-prick checks, using a CGM part-time, or using a CGM full-time over nine months. The goal…

This study is testing two experimental drugs, abrocitinib and ritlecitinib, to see if they can help preserve the body's remaining insulin-producing cells in people recently diagnosed with type 1 diabetes. The trial involves 78 participants aged 12-35 who were diagnosed within the…

This study is testing the safety and how the body processes teplizumab in very young children who show early signs of type 1 diabetes but don't yet have symptoms. About 20 children under age 8 will receive daily infusions of the drug for 14 days. Researchers will monitor the chil…

This study tests a family-based coaching program to help manage weight in children and teens with Type 1 diabetes who are also overweight or obese, and in their parents who have similar weight concerns. Over 6 months, 20 families will receive guidance on nutrition, physical activ…

This early-stage study tested whether implanting clusters of pancreatic cells into the abdomen could help adults with severe type 1 diabetes produce their own insulin. Participants would have needed to take lifelong anti-rejection drugs to prevent their immune systems from attack…

This study is testing whether adding mental health support to regular diabetes care helps adults with type 1 diabetes. Participants will complete surveys about their mood and health habits every six months. Some will also work with a mental health coach by phone or video to set p…

This study is testing whether providing a continuous glucose monitor and a dedicated Patient Navigator can help people with type 1 diabetes who have struggled with severe complications or high blood sugar. It aims to see if this combination of technology and personal support impr…

This study is testing if a medication called dulaglutide can improve the health of tiny blood vessels in the muscles of adults with type 1 diabetes. Researchers believe better blood flow might help the body use insulin more effectively. The trial is currently suspended and was co…

This study follows children and teenagers who recently received a drug called teplizumab for type 1 diabetes. The goal is to monitor their health for any long-term side effects over the next 3.5 years. No new treatment is given; researchers are just observing participants who fin…

This study is testing the safety of transplanting insulin-producing cells from donors into adults with severe, unstable type 1 diabetes. The goal is to see if this procedure can help control blood sugar levels, reduce or eliminate the need for insulin injections, and prevent dang…

This study is testing a new 6-month peer mentorship program designed to help teenagers with type 1 diabetes use their continuous glucose monitors (CGMs) more regularly. It compares the program, which includes monthly meetings with a mentor family and a health coach, to standard m…

This study aimed to test whether a combination of four drugs could help people recently diagnosed with type 1 diabetes keep making their own insulin. The goal was to see if this treatment could protect the body's remaining insulin-producing cells better than a placebo. The trial …

This study is testing if adding the common diabetes medication metformin to usual care can help prevent dangerous high blood pressure disorders during pregnancy in women with type 1 diabetes. Researchers are enrolling 60 pregnant women with type 1 diabetes to take either metformi…

This study is gathering feedback from 125 people with type 1 or type 2 diabetes who are already using the DuraTouch® injection device. Over 12 weeks, participants will rate how easy, convenient, and satisfying the device is to use in their daily lives. The goal is to understand t…

This study aims to understand how people with type 1 diabetes experience aging compared to people without the condition. Researchers will observe 400 participants over 65 years old to measure their physical, mental, and overall health. The goal is to identify what factors help pe…