CORONARY ARTERY DISEASE (CAD)

This study tests whether adding a low dose of colchicine (a well-known anti-inflammatory drug) to standard heart treatments can lower the risk of major heart problems like heart attacks and strokes. About 3,800 adults with stable coronary artery disease and non-blocking plaque wi…

This study is checking how safe and effective the SUPRAFLEX CRUZ stent is for people with blocked heart arteries. About 508 adults who already got the stent as part of their routine care will be followed for a year. Researchers will track serious heart problems like heart attacks…

This study compares two common heart procedures—bypass surgery (CABG) and stenting (PCI)—in 358 people with weak hearts (low pumping function) and multiple blocked arteries. The goal is to see which approach leads to better survival, fewer heart attacks or strokes, and improved q…

This study tests a new drug called SRSD107 in people with long-term heart or artery disease. The goal is to see if it safely lowers a protein linked to blood clots, which could reduce the risk of heart attacks or strokes. About 104 adults will receive either the drug or a placebo…

This study tests two methods to fix heart stents that haven't opened fully. About 80 adults with narrowed stents will get either a special balloon or a shockwave device. The goal is to see which approach opens the stent better, improving blood flow and reducing the need for repea…

This study is checking how well a new drug-coated heart stent (Coroflex ISAR NEO) works and how safe it is in 3,000 people with narrowed heart arteries. Participants get the stent as part of their regular care, and doctors will track heart-related events like heart attacks or the…

This study compares two treatments for people with completely blocked heart arteries (chronic total occlusions). One uses a drug-coated balloon to open the blockage, sometimes with a stent; the other uses a stent alone. The goal is to see if the balloon approach works as well or …

This study tests whether an artificial intelligence (AI) program can screen for coronary artery disease by analyzing facial images. Researchers will enroll 1,392 adults at high risk (those with diabetes, high blood pressure, or over age 65) and use the AI to sort them into high- …

This study is a registry that will enroll about 816 adults with coronary artery disease. It compares two imaging techniques: a CT scan of the heart (CCTA) and a more detailed internal camera (OCT) placed inside the arteries. The goal is to see how well the CT scan can identify da…

This study tests whether a new injection called XTR004, used with a PET scan, can better detect blood-flow-blocking narrowings in the heart arteries of people with known or suspected stable coronary artery disease. About 395 adults aged 18 to 80 will receive the injection and und…

This study tests whether using repeat CT scans of the heart to track plaque buildup can improve cholesterol control and prevent major heart problems like heart attacks and strokes. About 3,100 adults with non-obstructive coronary artery disease will be randomly assigned to either…

This study tests whether fexuprazan can prevent upper stomach bleeding in 400 heart patients at high risk of bleeding who need two blood thinners after getting a stent. Participants will take either fexuprazan or another standard drug daily for 6 months, and researchers will comp…

This study looks at 40 people with heart disease and weak heart pumping who are having bypass surgery. It compares two drug combinations (ketamine with lidocaine vs. ketamine with fentanyl) used to put patients to sleep. The goal is to see which combination better keeps blood flo…

This study follows 1,000 people with type 2 diabetes who have already had a heart CT scan. Researchers will repeat the scan to see how fatty plaque in heart arteries changes over time. The goal is to better understand who is at highest risk for heart attacks and other problems.

This study looks at whether a special ultrasound measurement of blood flow in all three main heart arteries can help predict serious heart problems like heart attacks or the need for additional procedures within one year. About 494 adults with significant narrowing in all three h…

This study tests a new way of caring for people with new-onset stable chest pain who might have coronary artery disease. Instead of going straight to cardiac catheterization, the new model uses a heart CT scan first, which is less invasive. About 3,369 participants across 16 regi…

This study is testing whether artificial intelligence can make CT scans of the heart better at predicting future heart attacks. Researchers will follow 10,000 adults who are already getting a heart CT for medical reasons. Participants will also give blood samples, have an ECG, an…

This study looks at how people with coronary artery disease (CAD) respond to arm versus leg exercise. Researchers will measure blood vessel stiffness, muscle oxygen levels, and energy use during both types of exercise. The goal is to better understand exercise limitations in CAD …

This study tests whether moving the patient's body during heart bypass surgery can control blood pressure as well as a standard drug called noradrenaline. Fifty adults having their first off-pump bypass will be randomly assigned to one of two groups. The goal is to see if the bod…

This study is collecting information from 5,000 people with coronary artery disease who are scheduled for a stent procedure. Researchers want to see if using a special CT-based tool (PCI Navigator) helps doctors plan the procedure more effectively than using X-ray images alone. T…

This study looks at over 12,000 people with coronary heart disease who take blood thinners. These patients face serious risks of blood clots or major bleeding. Researchers will use advanced tests on blood samples and medical images to find new markers that better predict these ri…

This study will track 100 adults using Fitbit devices to see if data like heart rate, sleep, and steps can predict heart disease risk. Researchers will compare wearable data with standard heart health assessments. The goal is to see if everyday wearables can help catch heart prob…

This study looks at using the ulnar artery in the wrist for heart procedures when the usual radial artery is blocked. About 127 adults with a blocked radial artery will be observed to see if using the ulnar artery is safe and how it affects hand strength and function. The goal is…

This study looks at 60 people with stable angina (chest pain) and two narrowed heart arteries. During a heart catheter procedure, they will exercise on a bike while a tiny balloon briefly blocks blood flow to measure exactly when symptoms begin. The goal is to understand why diff…

This study tracks 100 men aged 30-75 who had a heart procedure (stent placement) to see how their erectile function changes over 6 months. Half had a recent heart attack, half had stable chest pain. Researchers will use a standard questionnaire to compare the two groups and under…