CORONARY ARTERY DISEASE (CAD)

This study will enroll 150 people with blocked large heart arteries to compare two treatments: a new-generation bioabsorbable scaffold (a temporary, dissolvable stent) and a drug-coated balloon. Participants will be randomly assigned to one of the two groups and followed for up t…

This study looks at a new approach for people with acute coronary syndrome who have both high risk of blood clots and high risk of bleeding. After getting a special drug-coated stent, some patients will take blood thinners for only one month instead of the usual 12 months. The go…

This study tests whether taking royal jelly and propolis (natural bee products) for two months can reduce inflammation and improve heart health in 50 adults with coronary artery disease. Participants will be randomly assigned to receive the supplements or a placebo, and researche…

This study compares two treatments for complex coronary artery disease: a drug-coated balloon and a drug-eluting stent. About 2,184 high-risk participants will be randomly assigned to one of the two procedures. The goal is to see if the balloon works as well as the stent at preve…

This study looks at whether older adults (65+) who get a heart stent can safely stop one of their two blood thinners (aspirin) after just 7 days instead of taking it for months. The goal is to lower the chance of serious bleeding without increasing the risk of heart attack, strok…

This study tests a new device that uses sound waves to break up calcium buildup in heart arteries, making it easier to place stents. About 200 adults with hardened arteries will be treated at up to 8 U.S. sites. The goal is to see if the device works safely and effectively in rea…

This study compares a newer, less invasive heart bypass surgery (using small incisions and stents) to the standard open-chest bypass surgery. It includes 250 adults with three blocked heart arteries. The goal is to see which approach leads to fewer serious problems within 30 days…

This study looks at whether adding a special heart function test to standard artery-opening treatment (angioplasty) can better relieve chest pain and improve quality of life in people with blocked heart arteries. About 450 adults with significant blockages in a major heart artery…

This study will track 1,200 people with coronary artery disease who receive a drug-coated balloon during a procedure to open blocked heart arteries. The balloon delivers medicine to prevent the artery from narrowing again without leaving a permanent metal stent. Researchers want …

This study tests a home-based digital program to help people with coronary artery disease recover after a heart procedure. The program is designed for those who cannot easily attend in-person rehab, especially older adults, women, and people with other health issues. Researchers …

This study will test whether taking ginger supplements for two months can lower inflammation and oxidative stress in people with coronary artery disease (CAD). Researchers will measure changes in blood markers like IL-6 and C-reactive protein. The study involves 50 adults with st…

This study will track 2000 people with complex coronary artery disease who receive the Inspiron EVO drug-eluting stent during a procedure to open blocked heart arteries. The goal is to see how well the stent works and how safe it is in real-world patients with challenging blockag…

This study tests whether using only a drug-coated balloon to open blocked heart arteries (at a fork-like spot) works as well as the standard method of placing a permanent stent. About 272 adults with chronic coronary syndrome will be randomly assigned to one of the two treatments…

This study will test if a computer algorithm called ECGio can accurately detect significant coronary artery disease (blocked heart arteries) using only a standard electrocardiogram (ECG). Researchers will compare ECGio's results to detailed heart imaging tests in about 978 adults…

This study tests whether placing an ice bag on the groin area after a heart procedure (called PCI) can reduce pain and bruising. Sixty adults who had the procedure through the femoral artery will be enrolled. Researchers will measure pain levels and check for hematoma (a bruise-l…

This study looks at whether a mindfulness-based stress reduction program can improve quality of life, reduce anxiety, and increase feelings of empowerment in women with coronary artery disease. About 70 women aged 18-50 who have had heart disease for at least a month and have som…

This study tests a new therapy called EA-230 to see if it helps people recover faster after coronary artery bypass surgery. In an earlier trial, those who received EA-230 spent less time in the ICU and hospital and had fewer serious problems. This larger Phase 3 trial will involv…

This study looks at how low oxygen levels during sleep from obstructive sleep apnea (OSA) may damage tiny blood vessels in the heart. Researchers will follow 560 adults with suspected heart issues to see if sleep apnea patterns predict future heart problems better than standard t…

This study will collect information from 3,000 people with severely calcified coronary artery disease who are undergoing artery-opening procedures. Researchers will track which treatments work best in real-world settings, including advanced tools like lasers and imaging. The goal…

This observational study will enroll 150 adults aged 40-70 at intermediate heart risk to see if higher levels of lipoprotein(a) in the blood are linked to more calcium in the coronary arteries, as measured by a CT scan. Participants will provide a blood sample and undergo a non-c…

This study involves 3,500 adults with acute coronary syndrome who have received a heart stent and are at high risk for bleeding. Researchers will test a new quality control system to see if it helps doctors better manage blood thinner therapy, balancing clot prevention with bleed…

This study tests a new camera technology that measures heart rate and blood pressure from a short video of your face. Researchers will compare these readings to standard medical tests in 300 adults in Jakarta. If accurate, this could make heart disease screening easier and more a…

This study checks if a quick, low-cost arm exercise test (the 6-Minute Pegboard and Ring Test) is accurate and reliable for people with coronary artery disease. Researchers will compare it to a standard treadmill test. About 32 stable adults with CAD will participate. The goal is…