Balloons vs stents: new heart artery study could change treatment

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with CCS with documented myocardial ischemia in area supplying by the target coronary artery, not older than 80 years and with an expected life expectancy of at least 1 year * Patients with single- or multivessel disease and "true" (1.1.1; 1.1.0; and 0.1.1 according to the Medina classification) de novo bifurcation stenosis \> 50% and \<100% of the main coronary artery (excluding of the left main) or their large side branches. * Both main and side branches should be ≥ 2.0 mm and ≤ 4.5 mm in diameter (according to Quantitative coronary angiography - QCA or intravascular imaging) * Length of the main branch lesion should be no more than 30 mm * The total length of the side branch should be no more than 7 cm, and the side branch lesion length should be no more than 10 mm * Patients without hereditary coagulopathies * With a recent (at least 3 months) history of acute coronary syndrome (ACS) * Signed informed consent by patient to participate in the study Exclusion Criteria: * Patients with a single remaining artery supplying a large area of myocardium at risk, regardless of its caliber * Over 80 years of age * Bifurcation stenosis of the left main coronary artery and bifurcation lesions other than 1.1.1; 1.0.1, and 0.1.1 according to the Medina classification * The difference between the proximal and distal reference diameter of the main artery is \> 1 mm * Pregnancy or breastfeeding * Severe valvular heart disease requiring surgical or percutaneous intervention within 1 year * Life expectancy less than 1 year. * Chronic renal failure (glomerular filtration rate less than 30 ml/min) * Concomitant cancer * Heart failure \> NYHA class II * In-stent restenosis in bifurcation lesions after previously performed PCI * Presence of thrombus containing Lesion * Without concomitant chronic occlusion (bifurcation included in the chronic coronary occlusion (CTO)) * Patients at high bleeding risk (according to the PRECISE-DAPT score) * LV ejection fraction according to echocardiography ≤ 0.4 * Anemia (Hb \< 10 g/dL) * Thrombocytopenia and any coagulopathy * Episodes of significant bleeding and ongoing bleeding requiring modification of medical therapy * Acute coronary syndrome * PCI or coronary artery bypass grafting (CABG) performed according to clinical indications * Patient non-adherence to therapy, including antiplatelet and/or anticoagulant medications