APICAL PERIODONTITIS
Clinical trials for APICAL PERIODONTITIS explained in plain language.
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Blood clot breakthrough: new dental therapy boosts bone healing
Disease control CompletedThis study tested whether placing a patient's own blood concentrate (L-PRF) into the surgical site after dental root-end surgery improves bone healing. 15 adults with persistent tooth infections were followed for 12 months. The goal was to see if L-PRF leads to better bone regrow…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Seyda Ersahan, DDS, PhD • Aim: Disease control
Last updated May 26, 2026 08:45 UTC
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Tooth healing breakthrough: does drill size matter?
Disease control CompletedThis study looked at whether making a larger opening at the tip of the tooth root helps regenerative dental treatment work better in adults with infected teeth. 36 people with mature teeth and root infections received one of two treatment sizes. Researchers then checked for pain,…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Marmara University • Aim: Disease control
Last updated May 26, 2026 08:41 UTC
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Tooth pulp transplant with growth factors shows promise in small pilot study
Disease control CompletedThis small pilot study tested whether transplanting a patient's own tooth pulp, combined with concentrated growth factors, could heal dead teeth. Six people with infected, dead teeth received the treatment and were followed for 12 months. The goal was to see if the teeth regained…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Kahramanmaras Sutcu Imam University • Aim: Disease control
Last updated May 18, 2026 12:12 UTC
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Laser and sonic cleaners fail to ease Post-Root-Canal pain
Symptom relief CompletedThis study tested whether using a laser or different sonic cleaning tools during a root canal could lower pain after the procedure. Eighty adults with infected single-root teeth were split into four groups, each receiving a different cleaning method. Patients reported their pain …
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Biruni University • Aim: Symptom relief
Last updated May 26, 2026 08:32 UTC
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Root canal study: which sealer hurts less and heals better?
Symptom relief CompletedThis study looked at 72 adults with infected tooth roots to see if the type of sealer used during root canal treatment affects pain and healing. Patients received one of three common sealers, and their pain was checked right after, at 24 hours, and at 72 hours. Healing was checke…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Kahramanmaras Sutcu Imam University • Aim: Symptom relief
Last updated May 26, 2026 08:27 UTC
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New tool may ease pain after root canal retreatments
Symptom relief CompletedThis study looked at whether using a special electronic device during a second root canal treatment can lower pain afterward. 144 adults with infected teeth were treated using different settings on the device. Pain levels were tracked for a week. The goal was to see if the tool's…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Recep Tayyip Erdogan University • Aim: Symptom relief
Last updated May 22, 2026 14:04 UTC
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Which root canal rinse heals teeth faster? study compares sonic vs. ultrasonic
Symptom relief CompletedThis study tested whether using sonic or ultrasonic waves to activate cleaning solutions during root canal treatment helps infected teeth heal better than standard methods. 42 adults with a single infected tooth received one of three irrigation techniques. Researchers measured ch…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Hilal Çuhadar Beşiroğlu • Aim: Symptom relief
Last updated May 22, 2026 13:53 UTC
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Laser root canals may ease Post-Procedure pain
Symptom relief CompletedThis study tested whether using special lasers during root canal treatment can lower pain afterward compared to standard cleaning methods. 45 adults with infected front teeth were split into three groups: one got standard cleaning, another got a combination of two lasers, and the…
Matched conditions: APICAL PERIODONTITIS
Phase: PHASE2 • Sponsor: Future University in Egypt • Aim: Symptom relief
Last updated May 19, 2026 12:00 UTC
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AI helps dentists save infected teeth without root canals
Symptom relief CompletedThis study tested whether a less invasive dental procedure (full pulpotomy) works as well as a root canal in molars with severe infection. 58 adults with irreversible pulpitis were treated, and an AI tool helped detect hidden infections on X-rays. The goal was to see if the tooth…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Misr International University • Aim: Symptom relief
Last updated May 13, 2026 16:03 UTC
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Root canal rinse showdown: which one hurts less?
Symptom relief CompletedThis study tested two different rinses used at the end of a root canal to see which one leads to less pain afterward. 142 adults with an infected single-root tooth were treated in one visit. They received either octenidine or chlorhexidine as the final rinse. Pain was tracked for…
Matched conditions: APICAL PERIODONTITIS
Phase: NA • Sponsor: Bezmialem Vakif University • Aim: Symptom relief
Last updated May 13, 2026 15:58 UTC
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Laser fails to improve tooth infection healing in new study
Knowledge-focused CompletedThis study tested whether using a special laser (Nd:YAG) during root canal treatment could reduce inflammation and stress in infected teeth. Researchers measured certain markers in fluid from the tooth and gums in 58 adults. The results showed that adding the laser did not improv…
Matched conditions: APICAL PERIODONTITIS
Sponsor: Kırıkkale University • Aim: Knowledge-focused
Last updated May 26, 2026 08:33 UTC
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Blood injection may boost tooth infection healing, study finds
Knowledge-focused CompletedThis study looked at whether injecting a substance made from a patient's own blood (i-PRF) into the gums around an infected tooth could improve healing. Sixty adults with chronic tooth infections received standard root canal treatment, and half also got the i-PRF injection. Resea…
Matched conditions: APICAL PERIODONTITIS
Sponsor: Kırıkkale University • Aim: Knowledge-focused
Last updated May 26, 2026 08:31 UTC
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Mind your mouth: study links mental health to tooth infections
Knowledge-focused CompletedThis study looked at whether anxiety and depression are linked to a common tooth infection called apical periodontitis. Researchers at the University of Siena studied 120 adults, comparing those with and without the infection. They used questionnaires and dental exams to see if m…
Matched conditions: APICAL PERIODONTITIS
Sponsor: University of Siena • Aim: Knowledge-focused
Last updated May 26, 2026 08:29 UTC
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Root canal treatment may help blood vessels, new study suggests
Knowledge-focused CompletedThis study examined whether chronic tooth-root infection (apical periodontitis) is linked to changes in blood vessel function. Researchers measured inflammation and blood vessel barrier markers in 45 healthy adults, some with and some without the infection, before root canal trea…
Matched conditions: APICAL PERIODONTITIS
Sponsor: University of Turin, Italy • Aim: Knowledge-focused
Last updated May 19, 2026 11:48 UTC