APICAL PERIODONTITIS

This study compares a new iron-based nanozyme solution (ferumoxytol) to the standard root canal cleaner in 72 adults with infected root canals. The goal is to see if the nanozymes kill more bacteria and improve healing over two years. Participants will have their teeth treated an…

This study looks at whether adding extra ingredients to a standard root canal medicine can kill more bacteria in infected teeth. The trial will involve 45 adults with a tooth infection called apical periodontitis. Researchers will compare calcium hydroxide used alone versus combi…

This study tests a less invasive dental treatment called full pulpotomy for deep cavities in back teeth. It compares healing in teeth with and without infection at the root tip. 128 adults will be followed for a year to see if this simpler approach works as well as a root canal.

This study tests whether a new cleaning technology (GentleWave) is better than standard methods for disinfecting root canals in molars that still have infection after initial treatment. About 60 adults with persistent infection will be randomly assigned to receive either the new …

This study looks at whether using platelet-rich fibrin (PRF) during root-end surgery helps reduce pain and improve healing. PRF is made from a patient's own blood and may speed bone repair. Twenty adults with failed root canals on front or premolar teeth will be enrolled. Results…

This study compares garlic gel to the standard medicine (calcium hydroxide) placed inside a tooth during root canal treatment. Researchers want to see if garlic can reduce pain, swelling, and infection just as well, but with fewer side effects and lower cost. About 96 adults with…

This study will check how well root canal treatments work when done in general dental clinics, not just at specialist offices. About 1,500 adults who had a root canal in 2023 will get a free, painless check-up and X-ray three years later. The goal is to see how many teeth still s…

This study looks at three different ways to clean infected root canals in 66 men aged 18-35. The goal is to see which method best reduces signs of inflammation. Researchers will measure certain proteins in fluid from the tooth before and a week after cleaning.