Apical periodontitis

Researchers test whether a rinse made from frankincense (Boswellia sacra) removes bacteria from infected root canals as well as the standard sodium hypochlorite rinse. Thirty adults aged 18 to 50 with a dead or infected tooth take part. Each person is randomly assigned to one of …

This study tests whether a procedure called full pulpotomy can successfully treat permanent teeth with irreversible pulpitis and apical periodontitis. Instead of removing the entire nerve like a root canal, full pulpotomy removes only the inflamed pulp from the crown, preserving …

This trial asks whether a minimally invasive root canal procedure can match the success of the traditional approach in treating lower molars with dead nerves and an infected root tip. Sixty adults aged 20 to 50 with such molars will be randomly assigned to receive either a conser…

This trial tests whether adding silver nanoparticles to a standard antibiotic paste used inside root canals can better reduce pain and inflammation in people with symptomatic apical periodontitis, a painful infection at the tooth root. Half of the 50 adult participants receive th…

This study tests whether using platelet-rich fibrin (PRF) – a concentrate made from a patient's own blood – can reduce pain and improve healing after endodontic microsurgery (root-end surgery). Twenty adults with failed root canals and persistent infection in front teeth or premo…

This study tests whether a new cleaning technology (GentleWave) is better than standard methods for disinfecting root canals in molars that still have infection after initial treatment. About 60 adults with persistent infection will be randomly assigned to receive either the new …

This study compares two materials used to fill root canals during retreatment of infected teeth: standard gutta-percha and a newer material called MTA. About 58 adults with small infections around the tooth root will be treated and followed for one year. Researchers will check he…

This study looks at whether adding other medicines to a standard root canal disinfectant (calcium hydroxide) can kill more bacteria in infected teeth. The trial will involve 45 adults with a tooth infection called apical periodontitis who need a repeat root canal. Researchers wil…

This study tests if garlic gel can replace the usual medicine placed inside teeth during root canals. About 96 people with infected permanent teeth will get either garlic gel or calcium hydroxide. Researchers will check pain, swelling, and X-ray healing to see if garlic works as …

This study tests whether a less invasive dental procedure called full pulpotomy can heal infected molars as well as root canals. Researchers will treat 128 adults with deep cavities and compare healing in teeth with and without infection at the root tip. If successful, it may off…

This trial looks at whether changing how the dentist's tool moves during a root canal can reduce pain afterward. Adults with an infected lower premolar will get standard root canal treatment, but the file system will use either a continuous spin or a back-and-forth motion, with d…

This study compares two ways of using an anti-inflammatory drug (ketorolac) during root canal treatment: one at room temperature and one chilled. The goal is to see if the cold version reduces pain better after the procedure. Sixty adults with tooth infections will be enrolled, a…

This study looks at three different ways to clean infected root canals in 66 men aged 18-35. The goal is to see which method best reduces signs of inflammation and infection. Researchers will measure certain proteins in the fluid around the tooth root before and after treatment.

This study looks at how well root canal treatments work when done in general dental clinics, rather than specialist offices. Researchers will check about 1500 patients who had root canals in 2023 to see if infections remain after treatment. The goal is to understand why results m…