Subjective cognitive decline

This trial tests whether electro-acupuncture, a treatment that uses fine needles with a mild electric current, can improve memory and thinking in people aged 55 to 79 who have subjective cognitive decline, a condition where people notice memory problems but standard tests still l…

This study tests whether a special omega-3 supplement called Lysoveta can deliver more DHA to the brain than standard fish oil. Researchers will measure DHA levels in spinal fluid and blood, along with memory and thinking tests, in 153 older adults with early signs of memory decl…

This study tests a drug called NPC-1 (made of two natural compounds) in 40 adults aged 55+ with early Alzheimer's, mild cognitive impairment, or subjective memory concerns. The goal is to see if it safely changes blood markers linked to Alzheimer's brain changes. Participants tak…

This study tests a smart system that uses facial expressions to adjust computerized brain training in real time, aiming to keep older adults engaged and motivated. Researchers will enroll 80 people aged 60-89 with mild cognitive concerns. The goal is to see if this personalized a…

This study is testing whether new blood tests can accurately diagnose the cause of memory loss or dementia, potentially replacing the need for a spinal tap. Researchers will compare blood test results with standard spinal fluid tests in 1,200 people at a memory clinic. If success…

This study aims to make it easier for family doctors to detect early signs of Alzheimer's and other dementias. Researchers will test 1,200 adults with memory or thinking problems using blood tests and brain scans. The goal is to see if these tools can accurately identify who has …

This study tests whether artificial intelligence can predict cognitive test scores by analyzing how people tell a story. 150 adults aged 50 and older will describe a picture while their speech is recorded. The AI will look for patterns in voice and language, and researchers will …

This study explores whether a simple, at-home smell test can help detect early signs of Alzheimer's and other memory disorders. Researchers will ask 250 adults with mild memory or behavior concerns, as well as healthy older adults, to take a 45-minute scratch-and-sniff test using…

This study is testing whether a blood test for a protein called P-tau217 can help doctors make faster and better decisions for people with memory concerns. Researchers will compare what happens when doctors have the test results versus standard care. The study involves 7,000 part…

This study tests a brain health service designed to assess and reduce dementia risk in people aged 55 to 85 who have subjective cognitive decline (memory concerns without objective impairment). Participants are randomly assigned to either a personalized 6-month program—combining …

This trial tests whether taking golden oyster mushroom powder every day for two years can help preserve memory and thinking in middle-aged and older adults who are at higher risk for dementia. Around 600 community-living adults aged 45 to 80, who have a family history of dementia…

This study tests whether lifestyle changes like diet and exercise can help prevent dementia in adults aged 55 and older. Researchers will track 2,000 participants over three years, measuring memory, thinking skills, and how well people stick to healthy habits. The goal is to find…

This study tests an online educational program called Brain Health PRO in 700 Canadians at risk for dementia. Participants are randomly assigned to start the 6-month program immediately or after a 6-month delay. The program covers lifestyle factors like diet, exercise, sleep, and…

This study tests whether regular aerobic exercise can prevent or slow memory decline in older adults (ages 50-80) who have memory complaints but no dementia. Participants will be randomly assigned to either an aerobic exercise program or a stretching and toning group for six mont…

This study will test whether using a virtual reality (VR) headset for cognitive and physical exercises is practical and well-liked by people with mild cognitive impairment. Ten participants will do three supervised VR sessions per week for six weeks. The goal is to see if they ca…

This study tests whether three months of flicker stimulation (using near-infrared light or visual occlusion glasses) can improve thinking, movement, and mood in healthy older adults and those with subjective cognitive decline. Sixty participants aged 65-89 will be assigned to dif…

This study tests a program called the Green Activity Program, designed for people aged 45+ with mild memory problems. The program encourages enjoyable nature activities like walking, gardening, or outdoor yoga, with a partner. Researchers want to see if the program is easy to do …

This study tests whether spermidine, a natural substance found in foods like wheat germ, can improve sleep quality and memory in older adults with mild cognitive impairment (MCI), a condition that raises dementia risk. 76 participants aged 55-70 will take spermidine or a placebo …

This study tests whether exercising to beat-accented music helps older adults (65+) with memory concerns stay active and improve thinking skills. Eighty participants will be randomly assigned to a 6-month exercise program with or without special music. The goal is to see if music…

This study tests whether a home-based digital cognitive-training program called RICORDO can help people aged 50 and older with mild cognitive impairment or subjective cognitive decline better manage their own health. Participants will be randomly assigned to use RICORDO on a tabl…

This pilot study explores whether a music-based dance program can improve thinking skills and physical function in adults aged 55 and older with mild cognitive impairment. The dance routines combine music, partner guidance, and spatial coordination to challenge memory and attenti…

This study tests whether using a gentle nerve-stimulating device on the ear, combined with computer-based brain training, can improve thinking skills and mood in adults aged 45 to 80 who have noticed changes in their memory or attention. Participants will do 10 sessions at home a…

This study tests a portable device that plays soft sounds during deep sleep to improve memory and slow cognitive decline in older adults. Sixty participants aged 60-85 with mild memory problems will use the device at home for two 4-week periods. The goal is to see if enhancing sl…

This study tests whether a virtual reality (VR) app used at home with remote therapist guidance can improve memory, attention, and social skills in people with early memory decline (Subjective Cognitive Decline and Mild Cognitive Impairment). 480 adults aged 40-80 will either use…

This study tests a digital cognitive rehabilitation system called RICORDO for people with mild memory complaints, mild cognitive impairment, or early Alzheimer's dementia. About 102 participants will use the digital program or standard paper-and-pencil exercises at home for 5 wee…

This study tests whether a 24-week online positive psychology program can improve thinking skills and brain function in older adults with very early memory decline (subjective cognitive decline or mild cognitive impairment). About 128 participants will be randomly assigned to the…

This study tests whether internet-based cognitive behavioral therapy (CBT) can reduce depression and slow cognitive decline in older adults who survived an ICU stay. About 300 participants aged 50+ with depressive symptoms will receive either online CBT or standard depression edu…

This study tests whether a non-invasive brain stimulation technique called deep transcranial magnetic stimulation (dTMS) can improve memory and thinking in older adults who have memory concerns and a family history of Alzheimer's. About 30 people aged 55–70 will receive either re…

This study tests if a fast form of brain stimulation (accelerated dTMS) combined with memory exercises can improve thinking skills in older adults with mild memory issues. About 30 people aged 55-85 with mild cognitive impairment or memory concerns will receive either real or fak…

This study tests a new approach to improve sleep in people aged 60+ with mild cognitive impairment (MCI). It combines a gentle brain stimulation technique called TMS with an internet-based sleep therapy program. The goal is to see if this combo can ease insomnia and possibly boos…

This international observational study will follow 50,000 people with Alzheimer's disease or related dementias for many years. Researchers will collect real-world data from routine doctor visits to track how the disease progresses and how treatments are used and tolerated. The go…

Researchers are studying tiny particles released by brain cells into the blood, called glial extracellular vesicles, to see if they carry signs of inflammation that change as Alzheimer's disease advances. They will follow 48 people across three stages of the disease, from mild fo…

This study follows 600 people with neurodegenerative diseases such as Parkinson's, Alzheimer's, and related conditions over 1 to 10 years. Researchers collect data from routine clinical exams, brain imaging, movement analysis, and blood tests. They use statistical tools and artif…

This study tests whether a mild electrical current applied to the scalp (tDCS) can improve how the brain's vestibular network works, which may help with walking and navigation. Sixty older adults with memory concerns will receive either real or fake stimulation during three 20-mi…

This study is testing whether a smartphone app can help predict the risk of developing Alzheimer's disease. Researchers will collect health data like weight, blood pressure, and blood sugar from people with mild cognitive concerns. An artificial intelligence model will analyze th…

This study is testing whether proteins in the blood can accurately diagnose Alzheimer's disease and predict how quickly it will progress. Researchers will follow 2,000 adults with memory complaints for five years, collecting annual blood samples. The goal is to find a less invasi…

This study follows older adults (ages 70-95) who have memory concerns but no dementia, tracking them for up to 5 years to see who develops Alzheimer's. Researchers use brain scans, EEG, eye movement tests, and memory assessments to spot early warning signs. The goal is to better …

This study looks at whether adding a website and virtual coaching to basic activity tracking can help older adults who live alone, have mild memory concerns, and are not very active. 86 participants will wear a Garmin device, set step goals, and get weekly texts. Half will also g…

This study tests a new, non-invasive MRI technique to detect early brain changes linked to Alzheimer's disease. Researchers will compare brain scans from 50 people with mild memory concerns to healthy volunteers. The goal is to find a simple, affordable way to identify those at r…

This study looks at how older adults who worry about their memory may use extra brain power to stay mentally sharp. Researchers will give a medication that temporarily affects a brain chemical to see how attention networks respond. The goal is to understand these compensatory bra…

This study is creating a new computer-based cognitive assessment to help detect Alzheimer's disease in its earliest stages. Researchers are working with memory nurses and older adults to design the test and a training course for nurses. 120 older adults with memory concerns will …

This study tests whether eating walnuts daily for a week can improve thinking and memory in adults who feel their memory is slipping. Participants will eat either walnuts or a white chocolate bar each day, then switch after a break. Researchers will measure brain function and gut…

This study looks at whether 6 months of progressive resistance training (like lifting weights) can improve thinking and memory in perimenopausal women aged 40 to 55 who have mild memory complaints. Researchers will also measure muscle health, sleep, mood, and quality of life. The…

This study follows nearly 3,000 people, including healthy adults and those with memory or movement problems, to learn how brain diseases like Alzheimer's and Parkinson's develop. Researchers use advanced brain scans and tests to track changes over time. The goal is to improve ear…

This study follows 1,000 adults in Lombardy, Italy, who have early memory complaints but no dementia. Researchers will use blood tests and annual check-ups over 5 years to see if certain biomarkers can predict who later develops Alzheimer's. The goal is to improve early detection…

This study is looking for better, cheaper ways to detect Alzheimer's disease early. Researchers will collect blood samples, brain wave recordings, and speech recordings from 250 people who have noticed memory problems but still function normally. They will use machine learning to…

This study looks at people with cerebral small vessel disease, a common condition in older adults that can lead to stroke and dementia. Researchers will measure brain activity using EEG and test whether home-based cognitive training or mild brain stimulation can improve thinking …

This study follows 1,573 adults aged 50 to 90 across Canada, including people with different types of dementia and those with healthy memory. Researchers will use memory tests, brain scans, and blood samples to track how thinking and memory change over time. The goal is to better…

This study is testing whether a new, low-cost type of brain scan can find early signs of Alzheimer's and Parkinson's disease. Researchers will compare brain scans from 120 people, including those at risk for Alzheimer's, those with Parkinson's, and healthy volunteers. The goal is…