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Weight training may sharpen memory in perimenopausal women

NCT ID NCT07272174

Knowledge-focused Sponsor: University of British Columbia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether 6 months of progressive resistance training (like lifting weights) can improve thinking and memory in perimenopausal women aged 40 to 55 who have mild memory complaints. Researchers will also measure muscle health, sleep, mood, and quality of life. The goal is to understand if exercise can help protect the brain during this life stage.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Progressive Resistance Training (behavioral intervention)
What this could lead to
If it works, this could point toward a simple, drug-free way to protect brain health during perimenopause and potentially lower dementia risk later in life.
What could go wrong
This is a small, early-stage study with only 50 participants, so results may not apply to everyone. Exercise programs also require long-term commitment, and benefits may vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 55 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Are biological females, as assigned at birth * Are aged between 40 and 55 years * Had at least 1 menstrual period in the last 10 months * Are perimenopausal based on STRAW +10 Staging System, or answer "yes" to MQ6 questions of changes in periods, having hot flashes, or vaginal dryness, pain, or sexual concerns * Have an intact uterus * Have a Montreal Cognitive Assessment (MoCA) score \>26/30, indicating normal cognition * Have subjective cognitive complaints defined as responding "yes" to "Do you feel like your memory or thinking is becoming worse?" * Completed high school education * Read and speak English with acceptable visual and auditory acuity * Are able to safely engage in moderate-intensity PRT as indicated by the PAR-Q+; and * Are able to provide informed consent. Exclusion Criteria: * Are engaged in regular PRT (i.e., 2x/week) in the prior three months * Are diagnosed with cognitive impairment or dementia of any type * Are at high risk for cardiac complications during exercise * Have clinically important peripheral neuropathy or severe musculoskeletal or joint disease that impairs mobility * Are taking medications that negatively affect cognitive function, such as anticholinergics, major tranquilizers, and anticonvulsants * Have a BMI \<15 or anorexia nervosa; g) had surgical menopause * Had endometrial ablation that resulted in the loss of menstruation * Have polycystic ovarian syndrome * Currently undergoing chemo * Are using estrogen-containing contraception in the last 12 months * Had premature ovarian failure; or * Are already enrolled in a drug or exercise trial

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Conditions

The condition(s) this trial relates to.

subjective cognitive decline

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Perimenopause Subjective cognitive complaints

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of British Columbia

    RECRUITING

    Vancouver, British Columbia, V5Z 1M9, Canada

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