Respiratory failure

This study tests an experimental drug called recombinant human plasma gelsolin (rhu-pGSN) added to standard care for people with moderate-to-severe acute respiratory distress syndrome (ARDS) caused by pneumonia or other infections. About 600 hospitalized adults will receive eithe…

This study tests a new way to manage blood thinning in patients on ECMO, a machine that helps the heart and lungs. The goal is to reduce bleeding and clotting problems, which affect over 40% of ECMO patients. Researchers will compare a combination of two blood thinners (nafamosta…

This trial tests whether a device that sends mild electrical pulses to the spinal cord can help people with a cervical spinal cord injury breathe more independently. Twenty adults with a C1-C5 injury who need a ventilator will have electrodes implanted near the injury site and re…

This study will test a new medical device kit (Novalung ultimate kit with Xenios 2.0) in 20 adult patients with severe heart-lung failure who need ECMO life support. The goal is to see if the device safely and effectively maintains blood oxygen levels during hospital use and grou…

This pilot study tests two medicines, dopamine and norepinephrine, in 30 full-term or near-term newborns with low blood pressure and lung problems caused by pulmonary hypertension. The goal is to see which drug better improves blood flow and oxygen levels. Results could help doct…

This trial tests whether starting respiratory physiotherapy within one hour of breathing tube removal after elective coronary artery bypass surgery improves lung function and reduces complications compared to waiting until the next day. Forty adults undergoing planned heart surge…

This trial tests whether a type of minimally invasive lung surgery that avoids inserting a breathing tube (non-intubated thoracoscopic surgery) can reduce complications in patients with impaired lung function. These patients often need ICU care after standard surgery because thei…

This trial tests four different methods for setting the flow rate of a high-flow nasal cannula (a device that delivers warm, moist oxygen) after a breathing tube is removed. The goal is to find which approach best prevents the need for additional breathing support or re-intubatio…

This trial tests a real-time algorithm-driven system that gives doctors feedback on ventilator settings to protect the lungs of critically ill patients. The study will include 208 adults on breathing machines with acute respiratory distress syndrome (ARDS). The goal is to see if …

This study tests whether a personalized breathing machine strategy can improve survival in people with acute respiratory distress syndrome (ARDS), a severe lung condition. About 1,100 adults on ventilators will be randomly assigned to either standard care or a precision approach …

This phase 3 trial tests whether adjusting the flow rate of high-flow oxygen therapy based on lung volume measurements from a depth camera can reduce the need for intubation in intensive care patients with hypoxemic respiratory failure. About 406 participants will be randomly ass…

This study tests whether starting non-invasive ventilation (a breathing machine) earlier than usual helps people with ALS. Researchers will use a prediction tool to find those at high risk of breathing problems within 6 months. 48 participants will be randomly assigned to early N…

This study tests whether a single dose of an experimental immune cell therapy called agenT-797, given alongside standard care, can lower the risk of death in adults with severe pneumonia and breathing failure. About 90 people in intensive care will receive either agenT-797 or a p…

This study compares a nasal high-flow device to standard non-invasive ventilation (NIV) for treating people who come to the emergency room with a severe COPD flare-up and high carbon dioxide levels. Participants are randomly assigned to receive one of the two breathing supports f…

This trial tests whether a special alert system called ICU Beacon can help doctors in intensive care units detect early signs of organ failure. The study includes about 1,962 adult ICU patients and compares units using the software plus standard care to those using standard care …

This study compares two breathing support methods—high-flow nasal cannula (HFNC) and non-invasive ventilation (NIV)—in heart failure patients after their breathing tube is removed. The goal is to see which method better prevents the need for re-insertion of the breathing tube or …

This study looks at two ways to help ICU patients who struggle to breathe after their breathing tube is taken out. About 670 adults will be randomly assigned to receive either a non-invasive ventilation mask alternating with high-flow nasal oxygen, or high-flow nasal oxygen alone…

This study compares two ways of positioning patients with severe lung failure (ARDS) who are on a breathing machine: lying on the stomach for more than 48 hours straight versus 16 to 24 hours each day. The goal is to see which approach helps more people survive. About 780 adults …

This study tests whether awake patients with acute breathing failure who lie face down (prone positioning) for at least 10 hours a day for 3 days are less likely to need a breathing tube or die within 28 days, compared to standard care. The trial will include 342 intensive care u…

This study tests whether using a real-time lung imaging tool (EIT) to guide breathing therapy helps people who have been on a breathing machine for a long time. The goal is to see if this personalized approach helps them breathe on their own sooner compared to standard therapy. T…

This study compares two noninvasive breathing devices—BIPAP and a high-velocity nasal cannula—to see which helps patients recover faster from respiratory failure after major surgery. About 180 adults who develop breathing problems within 48 hours after surgery will be randomly as…

This study tests a device that uses light and a static magnetic field (PBMT-sMF) on adult ICU patients who need a breathing machine. The goal is to see if this therapy can reduce the number of days in the ICU and prevent diaphragm muscle weakness. Researchers will compare the act…

This study tests a method to set breathing machine pressures based on real-time lung measurements in obese patients. Researchers will insert a small balloon tube into the esophagus to measure lung pressure and adjust the ventilator accordingly. The goal is to see if this personal…

This study tests whether using a SPECT scan to map healthy, working lung tissue can help doctors aim radiation away from those areas during treatment for advanced lung cancer. The goal is to reduce lung damage and side effects like breathing problems. About 90 people with lung ca…

This trial tests two ways of using a breathing machine during surgery in 200 adults at high risk for lung complications. One method uses standard protective settings, while the other adjusts the machine based on each patient's lung stiffness. Researchers will track lung problems,…

This study tests whether measuring a blood marker called interleukin-6 (IL-6) can help doctors decide when to give anti-inflammatory drugs to patients hospitalized with acute respiratory failure. Patients with high IL-6 levels will receive either standard care, a single dose of t…

This study tests a new AI device called EMILY that automatically adjusts oxygen levels for people with acute or chronic respiratory failure. Researchers will enroll 20 adults in the hospital to see how well the device keeps oxygen in a safe range and how quickly it responds to ch…

This study compares two ways of using a heart-lung support machine (ECMO) during lung transplants: using it routinely for all patients versus using it only when problems arise. About 218 adults with end-stage lung disease will take part. The goal is to see which approach leads to…

This trial compares two ways to help patients breathe during a cardiac arrest in the hospital: a supraglottic airway (a tube placed in the throat) versus endotracheal intubation (a tube placed into the windpipe). About 1,060 adults who suffer cardiac arrest while hospitalized wil…

This study tests three ways to help patients with severe low oxygen levels breathe better without needing a breathing tube. About 1,200 adults will be randomly assigned to receive either a helmet mask that pushes air, a helmet mask that keeps airways open, or high-flow oxygen thr…

This study is testing whether a community-based exercise program can improve exercise capacity in 200 adults aged 18-85 with reduced heart or lung function. Participants will exercise 40-60 minutes, five times a week, for eight weeks, doing activities like brisk walking, jogging,…

This pilot study tests a self-management program based on cognitive behavioral therapy to help people who survived acute respiratory failure and now struggle with anxiety. Sixty ICU survivors will either receive the program or usual care. The goal is to see if the program is prac…

This study looks at two sedatives, ciprofol and propofol, given to ICU patients who need breathing support but are not on a ventilator. The goal is to see which drug works better and causes fewer breathing problems. About 1,680 adults from 30 hospitals in China will be included, …

This study compares two ways to help pneumonia patients who have trouble breathing: alternating between a mask that helps push air in (non-invasive ventilation) and high-flow oxygen through the nose, versus using high-flow oxygen alone. The goal is to see which approach improves …

This study compares a new FDA-approved suction device (EXSALTA) to standard suctioning in 30 preterm and term infants who are on breathing tubes. The goal is to see if the new device causes smaller changes in heart rate, oxygen levels, and brain oxygen levels during suctioning. E…

This study compares two ways of giving breathing support to adults with acute respiratory failure in the ICU. One group gets standard noninvasive ventilation (a mask that helps breathing), while two other groups get that plus a high-flow nasal cannula (a device that delivers warm…

This study compares two sedative drugs, remimazolam and propofol, in 90 adults having colonoscopy to remove polyps. The goal is to see which drug keeps the heart and breathing more stable during the procedure. Results may help choose safer sedation for routine colonoscopies.

This study tests whether adding music to standard exercise training helps people with COPD and chronic respiratory failure improve their walking distance and feel less breathless. 156 participants will either do usual rehab or rehab while listening to music they choose (rock, mod…

This study tests two types of breathing exercises together in people with ALS. The goal is to see if these exercises can improve cough strength and breathing, and reduce shortness of breath. Up to 34 people with ALS will participate, and the study also looks at how the exercises …

This study compares two methods of breathing trials for overweight and obese ICU patients before removing their breathing tube. One hundred adults with a BMI of 25 or higher who have been on a ventilator for over 24 hours will be randomly assigned to either pressure support venti…

This study tests whether music therapy can reduce stress and improve vital signs in children when their breathing tube is removed in the pediatric intensive care unit. About 82 children will be randomly assigned to receive either standard care alone or standard care plus music th…

This study tracks how quickly the diaphragm weakens in 15 ICU patients on mechanical ventilation. Researchers use advanced muscle tests and brain stimulation to measure changes in diaphragm function and control. The goal is to better understand ventilator-induced diaphragm dysfun…

Researchers at Evangelismos Hospital are studying adults who arrive in the emergency department with sudden acute hypoxemic respiratory failure, a condition where the blood oxygen drops dangerously low. The team collects clinical, imaging, physiological, and biological data early…

This study will observe how healthy lungs work by using two non-invasive tests: a special MRI that shows lung ventilation and a breathing test that measures airway resistance. Twenty healthy adults will participate to help researchers understand the relationship between these mea…

This study at West China Hospital follows 250 adults who need a breathing machine after major surgery. Researchers will record the machine's waveforms, which show how air moves in and out of the lungs, and check whether certain patterns warn of respiratory failure. The goal is to…

This study looks at how different levels of positive end-expiratory pressure (PEEP) on a ventilator affect the diaphragm and lungs in ICU patients with respiratory failure. Twenty-five adults on pressure support ventilation will each receive low, medium, and high PEEP for short p…

This study will use a non-invasive ultrasound test called Transcranial Doppler to measure blood flow in the brains of 125 children in the Pediatric Intensive Care Unit. Researchers want to see how brain blood flow changes during critical illness and whether those patterns relate …

This study observes 600 adult patients after major surgery to see if simple bedside tests—like ultrasound of breathing muscles and a breathing score—can predict who will need a breathing tube again. No new treatments are given; doctors make all decisions as usual. The goal is to …

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This study looks at two different approaches to deciding when to place a breathing tube in patients with acute hypoxemic respiratory failure (dangerously low oxygen levels). One strategy is more liberal (intubate earlier to prevent complications from low oxygen), while the other …

This study tests a web-based decision-support tool designed to help families and doctors make shared decisions about whether a child should go on chronic home ventilation. Half of the participating families use the tool, while the other half receive usual care. Researchers then m…

This study is testing whether a special breathing tube called a supraglottic airway can be used to help premature babies breathe right after birth. The study will include 20 premature infants born between 29 and 33 weeks who need breathing support. The goal is to see if this devi…

This study is testing a simple, non-invasive device that uses motion sensors on the chest and belly to measure breathing effort in children. The goal is to see if it can detect breathing problems early and help doctors decide when to start, increase, or stop breathing support. Th…

This study aims to develop a better way to remotely monitor people with chronic respiratory failure who use a breathing machine (noninvasive ventilation) at home. Researchers will collect data from standard monitoring tools and new non-invasive devices to assess breathing, lung f…

This study looks at whether giving extra oxygen during a 6-minute walk test helps people with chronic lung disease walk farther and feel better. About 114 adults with conditions like COPD or interstitial lung disease will do two walking tests—one with their usual oxygen and one w…

This study looks at whether the natural variation in heartbeat timing (heart rate variability) can help doctors decide the right oxygen flow for patients with respiratory failure who are on a high-flow nasal cannula. Researchers will gradually lower the oxygen flow and monitor he…

This study looks at whether a special nursing care model helps people with long-term health conditions like diabetes, heart disease, or Parkinson's work better with their advanced practice nurse. About 420 adults will take part. The goal is to see if this approach improves how pa…

This observational study with 300 ICU patients aims to see if combining blood markers (metabolomics) with standard clinical data can better predict when high-flow nasal cannula fails, requiring a breathing tube. Researchers will collect blood samples and monitor outcomes to build…

This study tracks quality of life in 200 adults with chronic respiratory failure who use breathing support like non-invasive ventilation. Researchers will use questionnaires to see how treatments impact daily living over time. The goal is to better understand patient experiences,…

This study tests whether a new measure called the Pressure-Muscle Index (PMI) can help doctors set ventilators more precisely for ICU patients with acute breathing failure. The goal is to avoid giving too much breathing support, which can harm the diaphragm and lungs. Thirty-six …

This study looks at 50 people with shortness of breath to see if a simple breathing test (oscillometry) can predict problems found during exercise testing. Participants will do both tests, and researchers will compare the results. The goal is to better understand what causes shor…

This observational study looks at 30 adults with acute respiratory failure on mechanical ventilation. Researchers want to see if a bedside device called electrical impedance tomography (EIT) can reliably guide ventilator pressure settings, compared to the current gold standard (C…

This study looks at how artificial intelligence (AI) can help emergency call operators quickly identify life-threatening situations like cardiac arrest, stroke, or severe breathing problems. Researchers will analyze millions of past emergency calls to train AI models to recognize…

This study looks at whether using an EEG (a device that measures brain activity) can give a more accurate picture of sleep quality in intensive care patients with acute respiratory failure, compared to the usual nurse assessments. About 47 adults in the ICU will have their sleep …

This study looks at whether combining two simple measures—a breathing test (RSBI) and a blood-based score (CALLY)—can better predict when ICU patients are ready to come off a breathing machine. About 105 adults will be followed for up to 7 days after the tube is removed. The goal…

This study is testing many different treatments for patients with severe breathing problems in the intensive care unit. It will include up to 6,250 participants and looks at various approaches like breathing machine settings, medications, and life support techniques. The goal is …

This study looks at whether a device that measures pupil reactions can help identify children at risk for opioid-induced respiratory depression after tonsillectomy. About 300 children will have their pupils measured before, during, and after surgery. The goal is to see if pupil p…

This study looks at how painkillers and sedatives are given to patients on ECMO, a life-support machine for severe heart or lung failure. Researchers will first review current sedation practices in UK hospitals, then work with patients, families, and staff to design a safer sedat…

This study tests a new portable CPAP device designed to help people with sudden breathing failure before they reach the hospital. Researchers want to see if the device is easy enough for non-medical people to use correctly. The study involves 50 participants: healthy older adults…

This study aims to create a new scoring system called REXs to better predict when patients on breathing machines in the ICU are ready to breathe on their own. The researchers will test this score in 470 patients to see if it can reduce the number of patients who need to be put ba…

This study looks at how body composition (like weight and fat distribution) relates to airway tone and reactivity. Researchers will use a device called an oscillometer to measure airway resistance in 100 people who are already scheduled for a methacholine challenge test. The goal…

This study looks at how using higher pressure during noninvasive breathing support affects oxygen levels in patients with low blood oxygen (hypoxemic respiratory failure). Researchers will measure changes in oxygen, breathing rate, blood pressure, and heart rate as they adjust th…

This study looks at whether a special ultrasound technique can help doctors choose the right oxygen flow for patients who have trouble breathing. Researchers will measure how the diaphragm moves in healthy people and in patients with respiratory failure. The goal is to see if thi…

This study looks at whether a protein called heparin-binding protein (HBP) in the blood is linked to fluid buildup in the lungs of intensive care patients. Researchers will collect blood samples and measure lung fluid using a special monitoring system in 25 adults. The goal is to…

This study looks at how the type of oxygen monitor and the oxygen level target affect the amount of oxygen given to ICU patients on high-flow nasal oxygen therapy. Researchers will test two different monitors and two oxygen targets in 30 adults. The goal is to see which combinati…

This study looks at how changing the pressure inside the lungs (called PEEP) affects how hard patients have to work to breathe while on a ventilator. Twelve adults in the ICU who are already breathing with some help from a machine will have their PEEP set to four different levels…

This study uses a safe, radiation-free device called electrical impedance tomography (EIT) to take pictures of the lungs in infants, children, and young adults up to age 25. Researchers will compare images from patients with chronic lung or heart conditions to healthy controls to…

This study is testing whether a machine learning tool can accurately detect air leaks when people breathe in while using a long-term breathing machine. Researchers will first train the tool on lab simulations and data from 10 patients, then test it on another 10 patients. The goa…

This study looks at whether patients with severe breathing problems in the ICU should be allowed to eat or drink before they need a breathing tube. Currently, patients are often kept fasting to prevent food from entering the lungs, but this can cause discomfort and malnutrition. …

This study follows 25 people with COPD and high carbon dioxide levels who use a breathing machine at night. Researchers want to see if nighttime breathing problems can predict how well the machine works over 6 to 12 months. They will also check lung function, diaphragm health, an…

This study will use a 3D electrical impedance tomography (EIT) device to monitor how lung ventilation and blood flow change when ARDS patients are placed on their stomach (prone position). Researchers will track 30 patients on mechanical ventilation at three time points: lying on…

This study is observing 1,000 adults in intensive care who need breathing support from machines like ventilators or high-flow oxygen. Researchers want to see how well automated software settings keep patients safe and within recommended breathing ranges. No new treatment is being…

This study looks at how different types of platelets change in patients on ECMO, a machine that helps the heart and lungs. Researchers will track 75 adults in intensive care to see if shifts in platelet populations relate to bleeding or clotting problems. The goal is to better un…

This study is testing a new method for giving muscle relaxants to patients with severe breathing problems who are on a breathing machine. The goal is to see if this approach is safe and possible, and if it helps patients breathe on their own more easily. About 23 adults in the ho…

This study follows 100 adults who needed ECMO support for severe heart or lung failure. Researchers will track muscle size, strength, and quality of life over time to understand why some patients develop lasting weakness. No new treatments are being tested; the goal is to gather …

This study looks back at medical records of about 59 ICU patients who used a low-flow carbon dioxide removal (ECCO2R) machine for breathing failure. The goal is to describe how the device was used and what happened to patients, including survival and side effects. It does not tes…

This study tests whether providing gentle nasal airflow to sedated, intubated patients with low oxygen levels can improve brain activity and lung function. Researchers will measure brain waves, blood flow, and lung ventilation under different airflow settings. The goal is to unde…

This study looks at how changing the pressure in a breathing machine (ventilator) affects the effort and drive to breathe in 20 ICU patients with severe lung failure. Researchers will test six different pressure levels and measure breathing muscles, lung activity, and oxygen leve…

This study looks at whether giving a paravertebral nerve block during chest surgery can lower the chance of problems like lung infections, collapsed lungs, or breathing failure. Researchers will follow 500 adults having keyhole or robotic lung surgery. The goal is to see if this …

This study involves 60 critically ill patients in the ICU who are on breathing machines (ventilators). Researchers want to see if a new scoring system can automatically detect when a patient is struggling to breathe. The goal is to improve how doctors monitor and care for these p…

This study compares three different facemasks used with a breathing machine (noninvasive ventilation) in 20 people whose lungs are not removing carbon dioxide well. The goal is to see which mask reduces the work of breathing and helps clear CO2 more effectively. Participants will…

This study looks at how different oxygen level targets and two types of oximeters affect the amount of oxygen given to patients in the intensive care unit. Researchers will test four combinations of target (90% or 94% oxygen saturation) and oximeter (Philips or Nonin) in 40 adult…