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Tiny study hopes to Fine-Tune ventilator settings for easier breathing

NCT ID NCT07437846

Knowledge-focused Sponsor: Pontificia Universidad Catolica de Chile Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how changing the pressure inside the lungs (called PEEP) affects how hard patients have to work to breathe while on a ventilator. Twelve adults in the ICU who are already breathing with some help from a machine will have their PEEP set to four different levels in random order. Researchers will measure breathing effort using a small balloon in the esophagus and other non-invasive methods. The goal is to understand which PEEP level reduces strain on the breathing muscles, which could help prevent lung injury.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Positive end-expiratory pressure (PEEP) level adjustment
What this could lead to
If successful, this could help doctors choose better ventilator settings to reduce lung injury in patients with respiratory failure.
What could go wrong
This is a very small, early-stage physiological study with only 12 participants. It measures short-term effects and may not translate into better patient outcomes or generalizable guidelines.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 12 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * Age ≥18 years. * ICU patients receiving invasive mechanical ventilation (endotracheal tube or tracheostomy). * Ventilated in an assisted mode with spontaneous breathing * Clinically stable to undergo protocolized PEEP changes. * Sedation level compatible with spontaneous breathing and ventilator triggering * Informed consent from the patient or legally authorized representative. Exclusion Criteria: * Contraindication to esophageal balloon placement (if applicable). * Significant hemodynamic instability or unstable vasopressor requirements. * Unstable arrhythmia or active myocardial ischemia. * Undrained pneumothorax or major air leak. * Controlled ventilation without effective spontaneous effort (apnea, neuromuscular blockade, deep sedation). * Pregnancy * Acute or chronic neurological conditions that may impair respiratory drive or interfere with the regulation of spontaneous breathing.

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Conditions

The condition(s) this trial relates to.

acute respiratory failure Respiratory Aspiration respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EFFORT Mechanical ventilation Respiratory failure

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hospital Clinico UC

    RECRUITING

    Santiago, Santiago Metropolitan, Chile

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