Nutritional deficiency disease

This study tests whether a structured, tailored nutritional care program helps children who need nutritional support after leaving the hospital. About 260 children from newborns to 18 years old will take part. Parents fill out questionnaires on eating behavior, stress, and food d…

This study tests a volunteer-led lifestyle program for older adults (60+) with sarcopenia, a condition causing muscle loss and weakness. The program includes workshops on nutrition and exercise, supported by nurses and trained volunteers. Researchers will measure changes in muscl…

This trial asks whether using a device that measures a person's actual energy needs (indirect calorimetry) is a better way to prescribe parenteral nutrition—liquid food given through a vein—for adults with cancer who cannot eat enough by mouth. Half of the participants will have …

This study tests whether a simple text-message system can help caregivers in Kenya spot and prevent malnutrition in children exposed to HIV. About 776 caregiver-child pairs will be split into two groups: one gets weekly SMS reminders to measure the child's arm and receive feeding…

This study is testing the safety of Omegaven, a fish oil-based fat emulsion, in 40 children under 18 who have developed liver problems (cholestasis) from long-term IV nutrition. The main goal is to see how many children develop essential fatty acid deficiency during at least 8 we…

This study tests a community-based nutrition program for 150 children aged 1-5 who are stunted or at risk. The program includes nutrition screening, education, supplements, and follow-up. The goal is to improve growth and reduce illness, not to cure malnutrition permanently.

This study looks at how safe SMOFlipid is for children and adults who need IV nutrition for 8 weeks or more. It checks if the treatment causes a lack of essential fats or liver problems. About 100 participants will be followed to see how their bodies respond.

This study looks at whether training local health workers to screen children for severe wasting and remind caregivers to measure their child's arm can get more kids the treatment they need. About 1,600 children in Turkana, Kenya, will take part. The goal is to see if this simple …

This study tests whether giving older patients at risk of malnutrition a food package, protein drinks, and dietitian support after hospital discharge can reduce readmissions and improve health. Researchers will enroll 2,000 patients aged 50 and older who are discharged with a lia…

This pilot study tests whether giving special nutritional shakes before and after surgery can improve the health of patients with critical limb ischemia, a severe form of peripheral artery disease. About 30 participants will drink the shakes for one to two weeks before and after …

This study tests whether a special medical food called LH VIOLA, taken as a partial replacement for regular meals, can help people with Crohn's disease or ulcerative colitis who are at risk of malnutrition maintain or regain weight and muscle strength. About 146 participants will…

This study tests whether giving DHA (a type of omega-3 fat) early to very preterm infants who are small at birth can improve head growth without causing too much fat gain. The trial will include 152 infants and measure head size and body fat at 36 weeks adjusted age. If successfu…

This study looks at whether giving patients with bone or soft tissue sarcoma a special nutritional supplement twice daily before surgery can reduce complications and help maintain muscle mass. About 100 adults scheduled for tumor removal will be randomly assigned to receive eithe…

This study tests a program that gives food supplements to pregnant women, new mothers, and their babies, along with advice on healthy eating, exercise, and infant feeding. The goal is to reduce both maternal obesity and child stunting in rural Indigenous communities in Guatemala.…

This study tests whether a high-energy liquid formula with added vitamins can improve nutrition in children under 5 who have chronic cholestasis (a liver condition that blocks bile flow) and severe malnutrition. Fifteen children will drink the formula for 14 days, and researchers…

This study looks at whether eating protein evenly throughout the day, combined with a regular exercise program, can improve nutrition, muscle mass, and strength in people with end-stage liver disease awaiting a transplant. 90 participants will be split into three groups: one with…

This study tests whether working through existing community groups can increase the number of children with severe acute malnutrition (SAM) who get proper treatment. Researchers will enroll 1,080 children aged 6-59 months in Ethiopia and measure how many receive care. The approac…

This study tests a new way to help doctors in Mozambique and Zambia decide if a sick child has tuberculosis (TB). The approach uses simple checklists and decision guides, supported by a computer system, to improve diagnosis and treatment, especially for children with HIV or sever…

This study tests whether daily high-calorie nutritional supplements can improve growth and development in 200 malnourished children aged 1 to 3 years. One group gets the supplements plus nutrition education, while the other gets only education and diet advice. Researchers will me…

This study looks at whether a plant-focused diet can help malnourished adults on peritoneal dialysis (a type of kidney treatment) improve their nutrition and overall health. About 100 participants will be randomly assigned to either a plant-focused diet or a standard kidney diet …

This study is testing a new protein drink (AYMES Protein Shot) in 40 adults with or at risk of malnutrition due to illness. The goal is to see if the drink is easy to take, tastes good, and causes any stomach issues. Participants will use the product for 28 days and report their …

This study aims to reduce food insecurity by providing plant-based food prescriptions to 100 low-income families. Participants will track their intake of fruits, vegetables, whole grains, legumes, and nuts/seeds. The goal is to improve access to healthy food and nutrition knowled…

This study looks at whether helping families with food benefits can improve weight in infants who are already overweight and at risk for food insecurity. About 228 infants aged 12 months and their parents will get $50 per week for one year, either as cash or as guided grocery sho…

This study tests whether adding milk fat globule membrane (MFGM) to a standard therapeutic food helps brain development and reduces death or hospitalization in 1,600 severely malnourished children aged 6-59 months in Sierra Leone. Children receive either the MFGM-enriched food or…

This study tests whether training caregivers to use a simple arm tape (mid-upper arm circumference) can detect malnutrition relapse in children who have recovered from severe acute malnutrition. About 2,400 children aged 6-54 months in Burkina Faso will be split into three groups…

This study tests whether a single dose of azithromycin helps children aged 6-59 months with severe acute malnutrition gain weight better than the standard 7-day amoxicillin course or a placebo. Researchers will enroll 3,000 children in Burkina Faso and track weight gain and nutri…

This study tests whether a supervised exercise program combined with oral nutritional supplements can prevent disability in hospitalized adults aged 75 and older who are malnourished or at risk. Around 102 participants will be randomly assigned to either the exercise-plus-nutriti…

This study compares a plant-based high-energy, high-protein drink to a dairy-based version in 80 adults who are malnourished or at risk. Participants drink two servings daily for 8 weeks. Researchers track calorie and protein intake to see if the plant-based option works as well …

This study follows 234 people who regained weight after a sleeve gastrectomy and are now getting a revision surgery. The goal is to compare three procedures—SADI-S, RYGB, and OAGB—to see which leads to the most weight loss, fewest complications, and best nutritional outcomes. Par…

This study looks at whether starting extra nutrition through an IV earlier (on day 4) versus later (on day 8) helps critically ill patients survive. About 946 adults with organ failure who cannot get enough nutrition from a feeding tube will be randomly assigned to one of the two…

This study tests whether daily supplements of lactoferrin and lysozyme, proteins found in milk, can prevent severe diarrhea and improve nutrition in children aged 6-24 months who were hospitalized with diarrhea and malnutrition. Six hundred children in Kenya will receive one of t…

Researchers are evaluating a program that gives mothers of 6- to 24-month-old children in rural Intibucá, Honduras a monthly voucher for 30 days' worth of eggs. The study compares children who receive the vouchers plus standard care with those who receive standard care alone. The…

This study compares two types of nutrient supplements—small-quantity and medium-quantity—to see if the smaller one works just as well at preventing undernutrition in children aged 6 to 12 months. About 980 infants in Pakistan will receive one of the two supplements daily for 6 mo…

This study looks at how to best provide multiple micronutrient supplements (MMS) to pregnant women through Uganda's health system. About 4,000 pregnant women will receive MMS in different bottle sizes to see which approach improves supplement use and clinic attendance. The goal i…

This study in Chad and Niger tests whether giving a small, nutrient-packed food supplement (SQ-LNS) to children aged 6 to 11 months can encourage families to complete routine vaccinations. Around 20,000 children will receive the supplement until they are 18 months old, and resear…

This study tests whether a group program for newly married women, their husbands, and mothers-in-law can reduce anemia and improve nutrition. About 2,100 people in 140 villages will take part. The program includes education on nutrition and gender norms, plus micronutrient supple…

This study tests a family-based program using a mobile app to help prevent childhood obesity in school-age children (5-9 years old) in Sonora, Mexico. The program includes guidance on healthy eating, physical activity, and positive parenting. Researchers will compare families who…

This study is testing a program called MyCarePulse and ASCENT to help cancer patients overcome food-related challenges. About 100 adults recently diagnosed with certain cancers will either receive the program or standard care. The goal is to see if the program improves food secur…

This study is testing a mobile app called Diet4painrelief that helps people with chronic pain improve their eating habits. About 200 adults with chronic pain and a BMI of 25 or higher will take part. The goal is to see if the app can reduce pain, improve sleep, and make daily lif…

This study tests whether remote nutritional counseling helps cancer patients stick to their treatment plan and feel better. 240 adults with invasive cancer starting therapy will receive either a single consultation with written materials or a more intensive program with monthly f…

This study tests whether a special protein drink called MediDrink Platinum+ can improve muscle strength, physical function, and overall well-being in adults aged 60 and older who have muscle loss (sarcopenia) and are malnourished. Participants will take the drink alone or with an…

This study tests whether serving food as easy-to-grip bites (finger food) helps elderly residents in care homes eat more, gain weight, and enjoy meals more. Thirty residents over 75 with weight loss or muscle loss will be randomly assigned to finger food or usual meals. The main …

This study tests whether a low dose of pancreatic enzymes (pancrelipase) taken with a nutritional supplement can help older adults at risk of malnutrition absorb nutrients better. Twenty hospitalized patients aged 70 or older will receive either the enzymes or a placebo alongside…

Researchers at hospitals across Indonesia are following infants under 6 months old who are admitted with acute malnutrition, diagnosed using the 2023 World Health Organization criteria. The study measures each infant's weight, length, head circumference, and mid-upper arm circumf…

This study looks at whether malnutrition changes how well older adults recover after shoulder surgery when they use virtual reality (VR) for rehabilitation. Researchers will track 60 frail adults aged 60+ to see if poor nutrition limits the benefits of VR therapy. The goal is to …

This study follows 130 adults undergoing surgery for stomach or esophageal cancer to see how often they experience postoperative delirium—a state of confusion and disorientation after anesthesia. Researchers will also check whether depression, frailty, poor nutrition, or muscle l…

This pilot study tests whether it's possible to run a larger trial comparing plant-based and animal-based oral nutritional supplements (ONS) in hospital patients at risk of malnutrition. Sixty patients from two Dutch hospitals will be randomly assigned to receive either a soy-bas…

This study aims to find out how common malnutrition and muscle loss (sarcopenia) are among adults visiting hospital clinics in Turkey. Researchers will screen 7,500 people aged 18 and older using questionnaires and simple physical tests like grip strength and calf measurement. No…

This study follows 142 adults having lung cancer surgery to see if measuring nutrition and muscle loss can help predict complications, hospital stay, and survival. Participants get blood tests, CT scans, and ultrasound before surgery. The goal is to create a better risk score to …

This observational study looks at how different settings in haemodiafiltration (a type of dialysis) affect people with kidney failure. It compares high versus low fluid exchange volumes and two different sodium concentrations in the dialysis fluid. Researchers will track toxin re…

This study investigates whether older adults with age-related hearing loss (presbycusis) can still hear and enjoy the sound of a crunchy biscuit while eating. Researchers will compare a crunchy biscuit with a soft one in 100 seniors aged 65 and older, asking them if they hear the…

This study is testing whether giving elderly patients with a broken hip and high frailty a special nutritional drink before surgery can help them stay more stable during the operation and recover better. Researchers will compare patients who get the drink with those who follow st…

This study surveys 150 women aged 18-64 who follow vegetarian or vegan diets to assess their nutritional quality and adequacy. Participants will receive personalized nutritional counseling based on blood tests and food diaries. The goal is to see if counseling can improve diet, b…

This study is testing whether giving monthly food vouchers to low-income households in the Philippines, along with nutrition classes, can reduce hunger and improve diet quality. About 5,320 families will be split into groups receiving different voucher amounts or no voucher. Rese…

This study looks at whether giving extra nutrition through a feeding tube before surgery can lower the chance of complications in malnourished people with esophageal or stomach cancer. About 670 participants will be followed to compare those who get nutritional support with those…

This study tests whether offering a small cash payment to households can encourage more people to get screened for tuberculosis (TB) in rural Tanzania. Researchers will enroll 360 people recently diagnosed with TB and their families. Half will receive the usual care, and half wil…

This study looks at how common muscle loss and weakness are in people with liver cirrhosis, and how malnutrition plays a role. Researchers will use ultrasound to measure muscle size and a grip test to check strength. The goal is to better understand the problem and its impact on …

This study is checking if a 7-year program by World Vision helps improve nutrition, gender equality, and health access for women, teenage girls, and young children in rural areas of Bangladesh, Kenya, and Tanzania. About 13,500 people will take part, including women, their partne…

This study is for older adults, including those in the hospital or with low priority care needs. Researchers want to see if newer methods, like body scans and blood tests, can better detect malnutrition and kidney problems than current standard tests. The goal is to make diagnosi…

This study tests a goat milk-based formula alternative (GMDFA) in 15 infants aged 8-10 weeks who cannot exclusively breastfeed. Researchers compare growth, gut health, and nutrition markers between infants fed GMDFA, undiluted goat milk, or breast milk. The goal is to see if GMDF…

This study tests a new, radiation-free ultrasound technology called REMS to measure bone density in children aged 5 to 18 who have conditions that weaken bones, such as brittle bone disease or osteoporosis. The goal is to see if REMS can work as well as the standard X-ray method …

This study tests whether giving extra arginine (a nutrient) to preterm and full-term infants after major bowel surgery or a serious gut infection (necrotising enterocolitis) can improve their immune function. Researchers will measure changes in gene activity related to infection-…

This study looks at how nutrition and body composition (like muscle and fat) impact the health of people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will follow 300 participants starting new medical treatments or having sur…

This study tests a mobile health app called First Diet to help new mothers in Pakistan improve breastfeeding and feeding practices for their infants. Researchers will enroll 300 pregnant women who have smartphones and follow them for one year after birth. The goal is to see if th…

This study tracks 300 adults who developed a surgical site infection after orthopedic surgery on their limbs or spine. Researchers will use questionnaires to measure how often depression and malnutrition occur over one year. The goal is to better understand these complications so…

This study tests whether a leadership program called LOCI helps nurses and their managers use the latest research in everyday care. About 300 nurses and managers from psychiatric and elder care units in Finland will take part. The program includes training and mentoring to improv…

This observational study follows 334 adults with type 2 diabetes or drug-induced diabetes who are malnourished or at risk. Researchers will track their nutritional treatment patterns after being prescribed a special high-calorie, high-protein supplement with fiber. Participants f…

This study looks at whether the ammonia in your breath can help detect malnutrition. Researchers will take breath and blood samples from 12 adults, some with and some without malnutrition, and compare the results. A small group will also drink special beverages and fast for two d…

This study tests a community-based program to reduce child malnutrition in Punjab, Pakistan. About 200 children aged 7-15 months and their mothers will take part in a 28-day behavior change program that includes daily group sessions and home visits. The program teaches practical …

This study aims to find out how common malnutrition is among hospital patients in China, Europe, and the USA. It will also look at whether providing nutrition support to those at risk improves their health outcomes and is cost-effective. Researchers plan to enroll 2,000 patients …

This study looks at how well malnourished children absorb iron from ready-to-use therapeutic foods. Researchers will compare healthy children with those who have acute malnutrition to see if too much iron causes problems like diarrhea. The goal is to make a safer, more effective …

This study is testing whether a special nutrition shake (Ensure Surgery Immunonutrition) can improve gut health and reduce inflammation in heart failure patients awaiting LVAD surgery. Researchers will give the shake to 50 hospitalized patients before their operation and track ch…

This study looks at whether patients in the ICU who need a tracheostomy can keep getting nutrition through a tube right up until surgery, instead of stopping 6 hours before. The goal is to see if this helps them get more food without increasing the risk of food getting into the l…

This study follows 368 mothers and their babies in Zimbabwe from pregnancy until the child turns 3. Researchers want to understand how malnutrition, poor water and sanitation, and gut problems affect child growth, infections, and development. They will measure gut bacteria, immun…

This study tests whether a plant-based, protein-dense sauce (ProSauce) helps older adults absorb essential amino acids better than a standard low-protein sauce, without making them feel too full. Twenty healthy adults aged 60 and over will eat two test meals in random order, and …

This study follows 48 adults with active Crohn's disease or ulcerative colitis who are starting biologic or JAK inhibitor therapy. Researchers use a quick, painless bioelectrical impedance scan to measure muscle mass and other body composition changes at the start, 24 weeks, and …

This study looks at how much protein cancer patients eat before, during, and after radiotherapy, and whether that affects their muscle mass and quality of life. Researchers will track 175 adults aged 45 and older undergoing radiation for various tumors. The goal is to understand …