Metastatic malignant neoplasm in the brain

This phase 2 trial compares two standard radiation approaches for people with large brain metastases (tumors that spread from other cancers). One method gives two radiation doses a month apart; the other gives three daily doses. The study will track tumor control, side effects, a…

This phase 2 trial is testing whether a combination of three drugs—nivolumab, ipilimumab, and cabozantinib—can help people with kidney cancer that has spread to the brain. The study will enroll 20 participants who have not had prior treatment for their brain metastases. The main …

Researchers at the University of California, Irvine are testing whether patients with brain metastases can safely skip immediate surgery or radiation and instead have their tumors monitored with regular imaging, cognitive tests, and quality-of-life questionnaires. All participant…

This study is for people whose brain metastases have returned after initial radiation. It combines either laser ablation or surgery with a second round of targeted radiation. The goal is to control the disease and monitor side effects in 155 participants.

This study is testing whether combining a targeted drug (abemaciclib) with precise radiation (stereotactic radiosurgery) can better control brain tumors in people with a common type of breast cancer (HR+/HER2-). About 31 participants will receive both treatments along with hormon…

This study tests an experimental oral drug called S241656 (BDTX-4933) in people with advanced solid tumors that have certain genetic changes (KRAS, BRAF, or other RAS/MAPK mutations). The trial has two parts: first, finding a safe dose, then testing how well it works alone or wit…

This study tests an oral drug called NEO212 in people with specific brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it helps control tumor growth. About 134 adults will take NEO212 alone or with sta…

This phase 2 trial compares two treatment combinations for people with BRAF-V600 mutant melanoma that has spread to the brain. One group gets a targeted therapy (encorafenib and binimetinib) plus an immunotherapy (nivolumab), while the other gets two immunotherapies (ipilimumab a…

This pilot study explores whether people with melanoma or non-small cell lung cancer that has spread to the brain can safely skip stereotactic radiosurgery (focused radiation) after having a brain tumor surgically removed. Instead of radiation, participants receive systemic thera…

This study tests a new drug called CBL0137 in children and young adults (ages 1 to 21) whose solid tumors, brain tumors, or lymphoma have returned or stopped responding to treatment. The goal is to find the best dose, check side effects, and see if the drug can shrink tumors. The…

This study tests whether combining radiation therapy with three drugs (platinum chemotherapy, adebrelimab, and bevacizumab) can control brain metastases from triple-negative breast cancer. About 58 adults aged 18-70 with this specific type of advanced breast cancer will receive t…

This study tests a drug called repotrectinib in 20 people with a specific type of lung cancer (ROS1-positive NSCLC) that has spread to the brain. The main goal is to see if the drug can shrink or eliminate brain tumors. Participants will take the drug by mouth, and doctors will m…

This phase 2 trial tests whether giving a precise, high-dose radiation treatment called stereotactic radiosurgery (SRS) before surgery to remove a brain tumor can prevent cancer cells from spreading to other parts of the brain during the operation. The study enrolls adults with b…

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard brain radiation can better control brain metastases that are at high risk of coming back. About 134 adults with certain cancers (like melanoma, lung, breast, or colorectal) that have spread to the br…

This study tests whether adding the drug olutasidenib to standard chemotherapy (temozolomide) can help children and young adults with a specific type of brain cancer (IDH1-mutant high-grade glioma) live longer. About 60 participants will receive the combination as maintenance the…

This phase 2 trial is testing a combination of three drugs—datopotamab deruxtecan, carboplatin, and pembrolizumab—in 46 people with non-small cell lung cancer that has spread to the brain and who have not had prior treatment for those brain tumors. The goal is to see how well the…

This early-phase study is testing two drugs together — alpelisib and pembrolizumab — in people with metastatic breast cancer or melanoma that has spread to the brain or other organs. The main goal is to find a safe dose and see what side effects occur. Up to 50 adults whose cance…

This trial is testing whether an experimental drug called TY-9591 can better control brain metastases in people with EGFR-mutated non-small cell lung cancer, compared to the current standard treatment osimertinib. The study will enroll about 420 adults with this type of lung canc…

This study tests whether a focused ultrasound device can safely open the blood-brain barrier in people with non-small cell lung cancer that has spread to the brain. About 30 participants will receive standard immunotherapy plus the ultrasound procedure. The goal is to see if this…

This study looks at whether giving focused radiation before or after surgery works better for people with brain tumors that started elsewhere in the body. About 140 adults with one brain tumor that can be removed will be randomly assigned to get radiation either before or after s…

This study tests personalized radiotherapy approaches for people with lung cancer, brain metastases, or other solid tumors. It aims to see if adapting radiation based on how a patient responds is safe and effective. About 45 adults will participate, receiving either extra radiati…

This phase II trial is testing whether an anti-viral drug called valganciclovir (Valcyte) can help treat breast cancer that has spread to the brain. The study includes 28 adults with progressive brain metastases who also have evidence of a common virus called CMV. Participants ta…

This study tests whether giving focused radiation (radiosurgery) before surgically removing brain metastases can prevent the tumors from coming back. About 36 adults with 1 to 4 brain metastases will receive radiosurgery followed by surgery. Researchers will also monitor side eff…

This trial investigates the safest and most effective dose of fractionated stereotactic radiation therapy (FSRT) for people with large brain metastases (tumors that have spread from other cancers). Participants receive radiation in several small doses over 1.5 to 2 weeks. The stu…

This study tests a drug called tarlatamab in 35 adults with small cell lung cancer that has spread to the brain but is not causing symptoms. The goal is to see if the drug can shrink or control these brain tumors. Participants must have already had standard chemotherapy and be in…

This study tests whether using a 0mm or 2mm margin around brain metastases during radiosurgery leads to better tumor control with fewer side effects. Radiosurgery delivers a high dose of radiation to kill tumors. The trial will enroll 180 adults with brain metastases up to 4 cm i…

This phase II trial tests a special way of delivering whole-brain radiation called pulsed reduced dose-rate (PRDR) along with the drug memantine to help protect memory and thinking in people with brain metastases. About 53 adults with solid tumors that have spread to the brain wi…

This study is tracking 600 people with brain tumors who receive GammaTile therapy during surgery. GammaTile is a device that delivers radiation directly to the tumor site to help prevent regrowth. Researchers are measuring how long tumors stay under control and how patients feel …

This study tests two treatments for people whose cancer has spread to the brain and is growing despite prior therapy. One group receives palbociclib alone; the other gets palbociclib plus pembrolizumab. The goal is to see if these drugs can shrink or stabilize brain tumors. About…

This study tests a new way to plan brain tumor surgery by creating detailed maps of each patient's brain networks using advanced MRI. Instead of relying only on standard anatomy, surgeons can see the white matter pathways and functional networks that could be affected. The goal i…

This phase IIa trial tests a combination of a dendritic cell vaccine (targeting HER2/HER3 proteins) and the immunotherapy drug pembrolizumab (Keytruda) in 23 women with breast cancer that has spread to the brain. The vaccine aims to train the immune system to attack cancer cells,…

This phase 2 trial tests whether two drugs, tucatinib and T-DM1, can control HER2-positive solid tumors that have spread to the brain. About 30 participants will receive both drugs, and researchers will monitor side effects and how well the treatment works. The goal is to find a …

This study compares bevacizumab (Avastin) to standard steroid treatment (dexamethasone) as the first therapy for people with brain radiation necrosis—a side effect of radiation therapy for brain tumors. About 408 participants with high-grade glioma or brain metastases will be ran…

This phase 2 trial tests belvarafenib, a daily pill that targets cancers with a BRAF mutation, in people with primary or metastatic brain tumors. Participants take the drug for about six months, and doctors monitor tumor response with scans. The goal is to see if the drug can con…

This early-stage trial tests whether giving a higher dose of focused radiation (stereotactic radiosurgery) to brain metastases is safe. About 50 people with 1 to 5 brain tumors who have never had brain radiation will receive an experimental dose on one tumor, while other tumors g…

This study is for people whose brain metastases have come back or caused radiation damage after initial treatment. It compares a laser-based procedure (LITT) plus standard care against standard care alone (steroids or repeat radiation). The goal is to see if LITT can better contr…

This study is for people with a specific type of lung cancer (EGFR-mutant NSCLC) that has spread to the brain. Researchers want to see if adding a precise, one-time radiation treatment (SRS) to the standard drug osimertinib is better than the drug alone at controlling brain tumor…

This study tests a new treatment for people with stage IV melanoma that has spread to the brain. It combines a chemotherapy drug (temozolomide) with specially grown immune cells (NK cells) from a healthy donor. The goal is to see if this combination is safe and can shrink brain t…

This study tests whether stereotactic radiosurgery (SRS), a precise form of radiation, can effectively treat brain metastases in people newly diagnosed with small cell lung cancer that has spread to the brain. About 62 participants will receive SRS, and researchers will track how…

This phase III trial is for people with 5 to 15 brain metastases from cancers that are not blood cancers. It compares two treatments: stereotactic radiosurgery (SRS), which delivers high-dose radiation to small spots in one or two days, versus whole brain radiation that avoids th…

This study tests whether a combination of two drugs, sacituzumab tirumotecan and bevacizumab, can shrink or control brain tumors in people with triple-negative breast cancer that has spread to the brain. About 24 adults whose cancer cannot be removed by surgery or radiation will …

This study tests whether adding two different drug combinations after radiation can help children and young adults (up to age 21) with high-grade gliomas, including DIPG, live longer. One group receives ribociclib plus everolimus; another gets ribociclib plus temozolomide. The go…

This study tests whether people with brain metastases from solid tumors can avoid radiation therapy if their brain tumors shrink or stay stable with systemic treatments like immunotherapy, targeted therapy, or chemotherapy. About 45 participants will be monitored with regular bra…

This early-stage trial is testing whether the drug sotorasib can get into KRAS G12C+ brain tumors and how safe and effective it is. Sixteen adults with these tumors who are already scheduled for brain surgery will receive the drug. Researchers will measure how much drug reaches t…

This phase 2 trial is testing a combination of three immune-boosting drugs (relatlimab, nivolumab, and ipilimumab) in 60 people with melanoma that has spread to the brain. The study includes both patients with and without symptoms from their brain tumors. The main goal is to see …

This study tests whether using a 3 Tesla MRI during surgery for brain metastases helps surgeons remove tumors more completely. About 154 adults will be randomly assigned to standard surgery or surgery with the MRI. The goal is to see if the MRI leads to better tumor removal and f…

This study tests whether giving focused radiation before surgery for large brain metastases works better than giving it after surgery. About 146 adults with solid tumors and one large brain metastasis will be randomly assigned to one of the two timing schedules. The main goal is …

This study compares two ways to prevent brain tumors from growing back after surgery. One group gets a chemotherapy wafer (GLIADEL) placed directly where the tumor was removed, while the other group receives radiation treatment within six weeks. The trial aims to see if the wafer…

This study tests a new treatment using natural killer (NK) cells, a type of immune cell, for adults with aggressive brain tumors that have not responded to standard therapies. The NK cells are grown in a lab and then given through a vein and directly into the brain. The main goal…

This phase II trial is testing two oral drugs, binimetinib and encorafenib, in 35 adults with advanced melanoma that has spread to the brain. The drugs block enzymes that help cancer cells grow. The study aims to see if this combination can control the disease and improve surviva…

This study tests whether two drugs, pembrolizumab and lenvatinib, can shrink brain tumors in people with breast cancer, lung cancer, or other solid tumors that have spread to the brain. About 87 participants will receive the combination therapy. The goal is to see how well the tr…

This phase 2 trial is testing whether giving systemic therapy first, followed by focused radiation (stereotactic radiosurgery), can better control brain metastases. About 316 adults with brain metastases that are low-risk will receive standard cancer drugs, then some will get rad…

This study tests whether giving radiation in one session or several sessions works better for people whose cancer has spread to the brain. About 90 adults with brain tumors between 2 and 4 cm will be randomly assigned to one of two radiation approaches. The goal is to see which m…

This study tests whether combining a targeted pill (adagrasib) with precise radiation (SRS) can control brain tumors in people with a specific type of advanced lung cancer (KRAS G12C mutation). About 30 adults with untreated brain metastases will receive both treatments. The main…

This phase III trial tests whether adding nitroglycerin patches to standard radiation therapy helps shrink brain tumors better than radiation alone in people with a specific type of lung cancer (EGFR-mutant non-small cell lung cancer). 74 participants will receive either radiatio…

This study looks at whether people with lung cancer that has spread to the brain can safely delay radiation therapy. Participants take alectinib, a targeted drug, either alone or with focused radiation. The goal is to see if starting with just the drug keeps the brain cancer unde…

This phase 3 trial tests two ways to treat lung cancer that has spread to the brain. One group gets targeted radiation to each tumor plus a drug (bevacizumab) that starves tumors of blood. The other group gets whole-brain radiation that tries to avoid the memory centers. The stud…

This study is for people with metastatic breast cancer that has spread to the brain, with at least two brain tumors. Participants receive an immunotherapy drug called pembrolizumab every three weeks, plus a precise, one-time radiation treatment to just one of the brain tumors. Th…

This study compares two radiation therapies for people with 4 to 15 brain metastases from cancer: stereotactic radiosurgery (SRS), which is done in 1-2 sessions, versus whole-brain radiotherapy (WBRT), which takes 10 sessions. The goal is to see if SRS offers similar survival wit…

This study tests whether giving a single dose of radiation before surgery for brain metastases can lower the chance of cancer spreading to the lining of the brain, compared to five doses after surgery. About 200 adults with brain tumors that can be removed will take part. The goa…

This early-phase trial is testing an investigational drug called risvutatug rezetecan in 15 people with recurrent glioblastoma or brain metastases. The drug is designed to seek out and deliver a cancer-killing payload to tumor cells. The study first measures how much drug gets in…

This study is testing a drug called zorifertinib as the first treatment for people with advanced non-small cell lung cancer that has a specific gene mutation (EGFR) and has spread to the brain or spinal cord. The trial will enroll 800 participants and compare zorifertinib to othe…

This study tests whether combining two drugs, niraparib and dostarlimab, can control advanced cancers that have spread to the brain. It includes 120 adults with certain cancer types like BRCA-mutated or lung cancers. The goal is to see if the treatment shrinks or stabilizes brain…

This study compares two types of radiation for people with up to 5 brain metastases from solid tumors. One group gets a single high dose of radiation, the other gets three smaller doses over a week. The goal is to see which approach better controls tumors and causes fewer side ef…

This study tests two or three drugs (defactinib, avutometinib, and possibly encorafenib) in people with advanced melanoma that has spread to the brain. The goal is to see if these combinations can shrink brain tumors and how safe they are. About 33 adults whose melanoma worsened …

This study tests whether adding the drug bevacizumab to a precise type of radiation therapy (fractionated stereotactic radiotherapy) can better control multiple brain tumors that have spread from lung adenocarcinoma. About 258 adults with 1 to 20 brain metastases will take part. …

This phase 2 trial tests whether using MRI-guided adaptive radiotherapy can safely eliminate extra safety margins around brain tumors, potentially reducing radiation-related brain damage. 168 adults with non-small cell lung cancer and 1-10 brain metastases will receive either the…

This study tests a new way to treat large brain tumors using two different radiation machines. Patients get four daily treatments with a linear accelerator, then a break, followed by one precise Gamma Knife treatment. The goal is to better control tumors while protecting healthy …

This study is testing a new, quick MRI technique called Magnetic Resonance Fingerprinting (MRF) to better tell the difference between a brain tumor coming back and damage from radiation therapy (radiation necrosis). About 90 people will take part, including healthy volunteers, pa…

This study tests whether using two contrast agents (gadolinium and ferumoxytol) in one MRI session can improve the detection and diagnosis of brain and central nervous system abnormalities. About 150 participants with neurological symptoms or known brain lesions will undergo imag…

This study tests a special MRI technique to help doctors tell whether an enlarged spot in the brain after radiation is the tumor growing back or harmless scar tissue from the radiation. About 100 adults with brain metastases who had radiation will get this MRI before any surgery.…

This study tests a radioactive tracer called FET that lights up brain tumor cells on a PET scan. Researchers want to see if FET can better detect whether a brain tumor has come back after treatment, and help tell high-grade from low-grade tumors. About 199 people with known or su…

This study tests a new type of PET scan that uses a special tracer (Ga68-PSMA) to see if it can tell the difference between a growing tumor and radiation damage in people with brain metastases from lung cancer, melanoma, or breast cancer. About 100 adults who have had radiation t…

This pilot study tests a special PET/MRI scan that uses a radioactive tracer to find HER2+ breast cancer that has spread to the brain. The scan aims to show whether the cancer cells take up the tracer, which might predict if they will respond to the standard drug trastuzumab deru…

This study tests a new type of PET/MRI scan to see if it can better tell the difference between a growing brain tumor and changes caused by radiation or immunotherapy. About 30 adults with brain metastases who have had radiation in the last 2 years will get a single 3-hour scan s…

This study looks at whether adding an early PET scan right after the injection can better tell the difference between a brain tumor coming back and damage from radiation therapy. About 50 adults with brain metastases who already need a PET scan will get an extra 15-minute scan ri…

This study aims to see if a special MRI scan called CEST can accurately tell apart radiation damage from tumor growth in people with lung cancer that has spread to the brain. About 60 adults who have had radiation therapy for brain metastases and show new changes on follow-up MRI…

This early-phase study is testing a new radioactive tracer for PET scans that may better detect non-small cell lung cancer that has spread to the brain. About 20 adults with this type of lung cancer and brain metastases will receive the tracer and undergo imaging. The goal is to …

This study tests a device called the CONVIVO system, which acts like a high-powered microscope during brain tumor surgery. It helps surgeons tell the difference between normal and abnormal tissue right away. About 30 adults with various brain tumors will take part. The goal is to…

This study tests a new MRI sequence that aims to make brain tumors (metastases) more visible after a standard contrast injection. Researchers will compare the new method to the usual MRI in 100 adults with known or suspected brain tumors. The goal is to see if the new scan finds …

This early study tests a special PET/CT scan that uses a modified tryptophan molecule to make tumors light up more clearly than normal tissue. About 24 adults with brain, breast, neuroendocrine, or rectal cancers will get one scan to see if this method helps doctors tell tumors a…

This study tests two advanced MRI techniques to better tell apart brain tumors that have come back from tissue damage caused by radiation therapy. About 42 adults with brain metastases will be scanned before surgery or radiation. The goal is to help doctors make more accurate tre…

This study is testing whether a very powerful 7 Tesla MRI can detect tiny brain metastases earlier than standard 1.5 or 3 Tesla MRIs in people with small-cell lung cancer who choose not to have preventive brain radiation. Twenty participants will get a 7T brain scan followed by u…

This study aims to improve how doctors find and treat breast cancer that has spread to the brain. Twenty adults with ER-positive breast cancer and brain tumors will get an extra PET scan (FES PET/CT) before their standard radiation planning. Researchers will compare this scan wit…

This study is building a large database of MRI scans from 3000 adults with malignant brain tumors (gliomas, metastases, lymphomas). Researchers will train an artificial intelligence system to automatically identify and classify these tumors. The goal is to improve non-invasive di…

This study tests a special PET/CT scan using a tracer called 18F-Fluciclovine to see if it can better detect brain metastases and tell them apart from changes caused by earlier treatments. About 20 adults with known or suspected brain metastases will get the scan before and after…

This study tests whether the seizure drug levetiracetam (Keppra) can prevent first-time seizures in people with brain metastases located in the motor cortex. About 150 adults who have never had a seizure will be randomly assigned to take the drug or receive standard care. The goa…

This Phase 2 trial tests a new type of radiation therapy designed to avoid key brain areas involved in memory and thinking. Sixty adults with 1 to 3 small brain metastases will receive cognitive-sparing stereotactic radiosurgery. The main goal is to see if this approach better pr…

This study is for people whose cancer has spread to the brain. It compares two types of whole brain radiation: one that avoids only the memory center (hippocampus) and one that also avoids other brain areas tied to thinking. The goal is to see which better preserves memory and co…

This study is testing whether it is safe to avoid giving the steroid dexamethasone before, during, and for three weeks after brain metastasis surgery. The goal is to see if patients can avoid the side effects of steroids without needing extra rescue doses. The trial will enroll 3…

This study tests a new type of whole brain radiation that spares healthy tissue, aiming to improve quality of life and reduce symptoms for people with brain metastases. About 41 adults with solid tumors and brain metastases will receive this radiation plus a standard drug. Resear…

This study tests whether slowly reducing the dose of the steroid dexamethasone after brain tumor surgery can lower side effects like high blood sugar and poor wound healing, while still preventing brain swelling. About 200 adults with certain brain tumors will be randomly assigne…

This study compares intensive multi-disciplinary care (a team of specialists working together) to standard care for 40 adults with newly diagnosed brain metastases from solid tumors. The goal is to see if the team approach reduces symptom burden and helps patients better understa…

This study tests a new program designed to help people with brain metastases manage thinking and memory problems. About 140 patients will receive different levels of support based on their needs, from educational materials to one-on-one coaching. The goal is to see if the program…

This early-phase trial tests whether giving the amino acid arginine alongside whole brain radiation is safe and how best to give it (by mouth or IV). Ten adults with cancer that has spread to the brain will receive arginine daily during their 10-day radiation course. The goal is …

This study asks brain cancer patients about their experience with telemedicine compared to in-person visits. Researchers want to learn if patients feel they receive good care through virtual appointments. The goal is to improve how care is delivered to people with brain tumors.

This study compares two ways of delivering precise radiation to brain tumors that have spread from other cancers. One group gets the standard extra 2-millimeter safety margin around the tumor, while the other group gets no extra margin. The goal is to see if skipping the margin l…

This study tests whether doing radiation planning and treatment on the same day can better target fast-growing brain metastases. About 60 adults with brain tumors that grow at least 1mm per week will be randomly assigned to receive radiation with a 1mm or 0mm safety margin. The g…

This study uses genetic testing of brain tumors from children, adolescents, and young adults (ages 1 to 39) with newly diagnosed high-grade glioma, including DIPG. The goal is to identify specific genetic changes in each tumor and then see if patients can join a treatment trial t…

This study is testing whether a small probe called a microdialysis catheter can be safely used during brain surgery to collect fluid samples from tumors. The goal is to measure biomarkers that could help doctors better understand and treat brain cancers like gliomas and metastati…

This study uses special MRI scans to see how radiation treatment affects the brain's white matter and thinking skills in people with cancer that has spread to the brain. Researchers will follow 15 patients to find early signs of memory or concentration problems. The goal is to be…

This early-phase trial will test a new PET imaging agent called 64Cu-DOTA-pembrolizumab in 6 people with stage IV non-small cell lung cancer who are already on the immunotherapy drug pembrolizumab. The goal is to see if the imaging agent can safely tell the difference between tum…

This study tests whether a brain mapping technique called navigated transcranial magnetic stimulation (nTMS) can help doctors plan radiation therapy better for people with brain metastases near the motor cortex. About 30 patients who had surgery for a brain tumor will get both a …

This study looks at why some older adults with serious conditions like cancer or fractures become vulnerable or frail. Researchers will follow about 1500 patients to find out how common different causes of vulnerability are and how they affect outcomes like survival and quality o…

This pilot study is exploring whether a one-time sample of spinal fluid (taken via a lumbar puncture) can detect cancer DNA in patients with solid tumors that have spread to the brain or spinal cord. Researchers will enroll 60 participants across three groups: those with leptomen…

This study looks at whether regular MRI scans of the brain after radiation therapy can find cancer that has spread to the brain before it causes symptoms. About 60 adults with stage III non-squamous lung cancer will get brain MRIs at set times. The goal is to see if this monitori…

This study tests a lab technique called pharmacoscopy that quickly checks which drugs work best on a patient's own brain metastasis tissue. About 102 adults with brain metastases and few treatment options will have their tumor samples tested. The goal is to see if using this test…

This study uses a special microscope called intravital microscopy to look at blood vessels inside solid tumors while patients are in surgery. Researchers want to see how these vessels work and how well they let blood and dye flow through. The goal is to learn whether tumor vessel…

This study looks at whether precise radiation (SRS or SBRT) can help preserve thinking and memory in people with multiple brain tumors that have spread from other cancers. About 90 adults with 1 to 10 brain metastases will get radiation and then take thinking tests over 4 months.…

This study is testing whether a special PET scan (using 18F-Fluciclovine) can help doctors see if brain tumors are responding to radiation treatment. About 46 adults with brain metastases will get the scan before and after stereotactic radiosurgery. The goal is to find a better w…

This study tests a special brain-mapping grid placed during surgery to better identify areas that control movement and speech. Researchers will compare this method with standard techniques in 75 adults with brain tumors. The goal is to see if the new grid helps surgeons avoid dam…

This study is testing whether a 15-minute app called Brainlab Cognition can be used in busy brain tumor clinics to track memory, attention, and other thinking skills. Researchers will also collect quality-of-life reports electronically from patients. The goal is to see if this ap…

This study is testing a new radioactive tracer called [C-11]-CS1P1 that lights up inflammation in brain tumors during a PET scan. Researchers will scan 104 adults with primary or secondary brain cancers before and after treatment to see how inflammation patterns change. The goal …

This study is testing a special imaging agent called 18F-fluciclovine to see if it can detect how well radiation therapy is working on large brain tumors that have spread from other cancers. About 20 adults with at least one untreated brain tumor larger than 2 cm will get PET/CT …

This study looks at tissue samples from 30 adults with stomach or esophageal cancer that spread to the brain. Researchers compare the genetic markers of the original tumor and the brain tumor to see if they differ. The goal is to better understand how these cancers change when th…

This observational study uses a special MRI technique with hyperpolarized carbon-13 pyruvate to see how brain tumors use energy. Researchers will measure metabolic byproducts in 25 adults with brain tumors before any treatment. The goal is to learn more about tumor metabolism, no…

This phase 2 trial is testing whether CT and MRI scans can act as biomarkers to predict how patients with brain metastases respond to radiation therapy. About 90 adults with brain metastases who are scheduled for radiation will get scans before and after treatment. The goal is to…

This study aims to develop and test a new MRI technique to distinguish between actual tumor growth and changes caused by radiation treatment in people with brain metastases. Researchers will include both healthy volunteers and patients who have had stereotactic radiosurgery. The …

This early-phase study tests a special PET imaging agent that highlights immune cells (CD8+ T-cells) in brain tumors. About 20 adults with brain tumors scheduled for surgery will receive an injection of the imaging agent before their PET scan. The goal is to see if this non-invas…

This study is testing a special MRI technique called CEST to create detailed maps of acidity (pH) inside brain tumors like gliomas and metastases. Researchers will scan 800 patients who are already getting a PET/MRI for their brain tumor. The goal is to see if pH levels can help …

This study is testing a special MRI technique that uses a substance called hyperpolarized 13C-pyruvate to look at how brain metastases (tumors that spread to the brain) use energy. The goal is to see if this scan can help doctors understand which tumors are more likely to resist …

This study uses brain mapping techniques like fMRI and MEG before, during, and after surgery to see how brain functions like movement and speech reorganize in people with brain tumors. Researchers hope to improve surgical planning and preserve important brain functions. The study…

This study is growing miniature versions of breast cancer tumors, called organoids, from samples taken during surgery. Researchers want to see if these lab-grown organoids can predict how well a patient's cancer will respond to treatments like chemotherapy or radiation. If the or…

This study tests whether a special PET scan using an investigational agent called 18F-Fluciclovine can find leftover tumor tissue after brain metastasis surgery better than standard MRI. About 20 adults who have had brain tumor surgery and are scheduled for radiation will get an …

This study is creating a collection of blood samples from 300 adults with primary or metastatic brain tumors. Researchers will analyze immune cells in the blood to better understand these tumors. The goal is to provide a resource for future studies, not to test a new treatment.

This study looks at heart problems in people with HER2+ breast cancer that has spread. All participants are taking trastuzumab-based treatment. The main goal is to see how often heart issues occur, especially in those also taking beta blockers or similar heart medications. A smal…

This study tests whether a digital website called Careverse can help caregivers of people with serious illnesses engage more in advance care planning. About 200 caregivers will be randomly assigned to use the website or receive usual care. Researchers will measure how involved ca…