Fatty liver disease

Researchers are testing resmetirom, an oral drug, in adults who have metabolic dysfunction-associated steatohepatitis (MASH) and heart failure with preserved ejection fraction (HFpEF). The trial assigns participants to receive resmetirom or a placebo for 24 weeks. The main goals …

This early-stage trial is testing a new drug called ACT500 in 24 people who have both fatty liver disease and chronic hepatitis B. The main goal is to check the drug's safety and how the body processes it at different doses. Participants will take ACT500 or a placebo daily, and r…

This early-stage study tests a new oral drug called ACT500 in 24 adults with fatty liver disease (MASLD). The main goal is to check safety and how the drug moves through the body. Participants take one pill daily in different dose groups. The study does not aim to cure the diseas…

This trial tests whether mazdutide, a weekly injection that targets GLP-1 and glucagon receptors, can safely reduce portal pressure in overweight adults with compensated cirrhosis and clinically significant portal hypertension. Participants receive 16 weeks of mazdutide, with the…

This trial is testing whether adding dapagliflozin to metformin can improve levels of a growth-related hormone (IGF-1) in men with type 2 diabetes and fatty liver disease. The study will include 84 men aged 30-60 who are already taking metformin. Half will continue metformin alon…

This study tests whether semaglutide (a GLP-1 drug used for diabetes and weight loss) can help people with obesity and fatty liver disease reduce or stop drinking alcohol. 64 participants will receive either semaglutide injections plus lifestyle counseling, or counseling alone. T…

This trial tests whether replacing some of the usual diet with navy beans — without changing total calories — is a practical and acceptable way to help manage metabolic dysfunction-associated steatotic liver disease (MASLD) in adults with intermediate-stage liver fibrosis. Forty …

This trial tests whether a daily supplement of 5-methyltetrahydrofolate (a form of folate) can improve markers of liver health in people with metabolic dysfunction-associated steatotic liver disease (MASLD), a common type of fatty liver. Over 90 days, participants receive either …

This trial tests whether a diet low in advanced glycation end products (AGEs)—compounds formed when food is grilled, fried, or toasted—can improve liver function and reduce fat buildup in adults with metabolic fatty liver disease. Over 12 weeks, one group will follow AGE-restrict…

This study tests whether a 12-week program combining a weekly injection of mazdutide (a drug that targets gut hormones) with lifestyle counseling can quickly reduce liver fat in overweight or obese people who want to donate part of their liver but are temporarily disqualified due…

This study tests whether switching to a new drug called mazdutide can reduce liver fat more effectively than staying on semaglutide in people with type 2 diabetes and moderate-to-severe fatty liver. Participants who have been on semaglutide for at least 16 weeks are randomly assi…

This study tests whether a traditional Chinese medicine formula called Chazhu Xiaoli Formula (CXD), combined with a very low-carb (ketogenic) diet, can reduce liver fat in people with MASLD (fatty liver disease). 135 adults aged 18-50 will be randomly assigned to one of three gro…

This trial investigates whether high-intensity interval training or moderate continuous exercise, combined with a Mediterranean diet, can improve gut bacteria and metabolic health in people with non-alcoholic fatty liver disease. Participants are adults aged 40-60 with obesity an…

This Phase 3 trial tests an investigational biologic called DR10624, given as a weekly injection, in adults with severe hypertriglyceridemia (very high blood fats) who are already on standard lipid-lowering therapy. The study compares two doses of DR10624 against a placebo to see…

This study will test whether eating a diet rich in whole fruit (up to 50% of daily calories) for 17 weeks can improve blood sugar control, reduce liver fat, and lower heart disease risk in adults with type 2 diabetes who do not use insulin. Participants will eat fruit prepared in…

This study tests whether adding a Mediterranean-style meal delivery program to resmetirom therapy improves liver health more than resmetirom alone. It involves 120 adults with non-cirrhotic MASH who are starting resmetirom. Participants either receive the drug plus 10 medically t…

This trial investigates whether a supplement called butyrate (a substance produced by gut bacteria) and an intensive lifestyle program (Mediterranean diet plus exercise) can reduce liver fat in adults with type 1 diabetes who also have fatty liver disease. Participants are random…

This phase 2 trial tests whether a high-protein diet (30% protein, 40% carbs, 30% fat) can reduce liver fat and improve liver function in 72 adults with alcoholic fatty liver disease. Participants will be randomly assigned to either the high-protein diet or a standard diet for 6 …

This Phase 3 trial tests whether the drug HSK31679 can safely improve liver health in 400 adults with MASH, a serious fatty liver disease. Participants will take either the drug or a placebo daily for about a year. The main goals are to see if the drug can reverse liver inflammat…

This study tests an experimental drug called ALN-CIDEB in 150 adults with MASH, a serious liver disease involving fat buildup and scarring. The goal is to see if the drug can reduce liver fat, injury, and scarring compared to a placebo. Participants will receive either the drug o…

This study tests whether a Chinese herbal capsule called Linzhi Jianghuang Fufang Huoxue Anshen (LJF) can safely reduce liver fat in people with non-alcoholic fatty liver disease. About 180 adults aged 18 to 65 with high liver fat will take the capsule or a placebo for 24 weeks. …

This Phase 2 trial tests a new drug called QL2401 in 132 adults with metabolic dysfunction-associated steatohepatitis (MASH) and moderate liver scarring. Participants receive weekly injections of either QL2401 or a placebo for 48 weeks. The main goal is to see if the drug reduces…

This phase 2 trial tests whether daidzein, a natural compound found in soy, can improve liver tissue health in adults with metabolic dysfunction-associated steatotic liver disease (MASLD). 44 participants scheduled for gallbladder surgery will take daidzein capsules or receive st…

This study tests if the drug finerenone can prevent chronic kidney disease in adults with liver cirrhosis caused by fatty liver disease (MASLD) who also have fluid buildup in the belly (ascites). About 160 participants will receive either finerenone or spironolactone, along with …

This study looks at whether exercising in the morning or evening makes a bigger difference in reducing liver fat for postmenopausal women with fatty liver disease. Sixty-three women will be placed into morning exercise, evening exercise, or a no-exercise group for 12 weeks. Resea…

This early study tests whether adding an experimental drug (CS0159) to a standard diabetes medication (semaglutide) can help people with fatty liver disease, obesity, and type 2 diabetes lose weight and improve their health. About 30 adults will take the combination or a placebo …

This phase II trial tests whether a palm-derived form of vitamin E (tocotrienol) can improve liver health in adults with alcoholic fatty liver disease. 26 participants will take either the supplement or a placebo for six months, with regular blood tests and liver scans to track c…

This study looks at whether combining a probiotic supplement with resistance exercise can help people with metabolic fatty liver disease (MAFLD/NAFLD). Researchers will measure changes in liver fat using MRI over 12 weeks. The goal is to find out which patients benefit most based…

This study tests whether giving a bile acid pill (TUDCA) to breastfeeding mothers with fatty liver disease can make their breast milk healthier for their babies. Eighty mother-infant pairs will be randomly assigned to receive TUDCA or a placebo for a short time after birth. The g…

This study compares a traditional Mediterranean diet to a fully plant-based version in 50 adults with metabolic liver disease. Over 12 weeks, researchers will measure changes in liver fat, body weight, and overall health. The goal is to see if cutting out animal foods leads to be…

This study tests whether an artificial intelligence (AI) program that gives personalized diet and exercise advice can help people with non-alcoholic fatty liver disease (NAFLD) reduce liver fat more than standard lifestyle counseling. About 216 adults with NAFLD and overweight wi…

This phase 4 trial will test whether adding alogliptin to a standard two-drug regimen (pioglitazone and metformin) improves blood sugar control and liver health in 80 adults with type 2 diabetes and fatty liver disease. Participants must not have used diabetes medications in the …

This study tests a new drug called SNP-610 for people with non-alcoholic steatohepatitis (NASH), a type of fatty liver disease. About 80 adults will receive either the drug or a placebo for 3 months. The main goal is to see if SNP-610 lowers liver enzyme levels and reduces liver …

This study tests whether the DASH diet (a heart-healthy eating plan) can improve liver health in 88 children aged 11–18 with MASLD, a common fatty liver condition linked to obesity. Participants will follow the DASH diet for 12 weeks, and researchers will measure changes in liver…

This study tests whether adding electroacupuncture to a standard diet and medication plan can reduce central obesity and fatty liver in postmenopausal women. Sixty women aged 50-60 with obesity will receive the same diet and orlistat for 12 weeks, but half will also get electroac…

This study tests a temporary device placed in the upper small intestine to help control type 2 diabetes and obesity. The implant stays for 6 months and is then removed. Researchers will check if it lowers blood sugar (HbA1c), helps with weight loss, and improves liver health in p…

This early-stage trial is testing a new drug called XTYW007 in healthy volunteers and people with high LDL cholesterol. The main goal is to check the drug's safety and how the body processes it, not yet to see if it treats non-alcoholic fatty liver disease (NAFLD). The study will…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce liver fat in people with alcohol-related fatty liver disease (MetALD). 105 participants will receive either personalized rTMS, standard rTMS, or a sham (placebo) treatment over 20 sessions.…

This study looks at whether oral semaglutide, a drug already used for diabetes, can slow kidney disease in people who also have fatty liver disease. About 90 adults with both conditions will receive either the drug or standard care for 2 years. Researchers will track kidney funct…

This study tests whether empagliflozin, a drug used for diabetes, can help teens with non-alcoholic fatty liver disease (NAFLD) and obesity. Forty participants will take either the drug or a placebo for several weeks. The main goal is to see if the drug reduces liver fat measured…

This study will test two supplements — essential phospholipid and betaine HCL/L-glutamic acid — in 200 adults with metabolic fatty liver disease (MAFLD). The goal is to see which one reduces fat in the liver more effectively. Participants will be followed for a period to measure …

This study tests whether betaine, a natural substance found in the body, can reduce liver injury in people with MASH (a serious fatty liver disease). Seventy participants will take either betaine or placebo pills for 24 weeks, with follow-up for another 24 weeks. The main goal is…

This study tests whether a traditional Chinese herbal formula called Longqi Jiangzhi decoction can help treat non-alcoholic fatty liver disease in adults. Eighty participants will take either the herbal medicine or a placebo daily for eight weeks. Researchers will measure liver f…

This study tests whether taking rutin (a plant compound found in buckwheat and citrus) along with vitamin C can reduce inflammation and oxidative stress in people with metabolic fatty liver disease (MASLD). 120 adults will take either rutin plus vitamin C, vitamin C alone, or fol…

This study tests whether taking glycine, a natural amino acid, as a daily supplement for 26 weeks can improve liver health in people with metabolic fatty liver disease. Researchers will compare liver fat and blood markers between those taking glycine and those taking a placebo. T…

This study tests two blood products used to control bleeding during liver transplant surgery. It compares a newer product, Intercept Fibrinogen Complex, to standard cryoprecipitate. The goal is to see if the newer product works as well or better at stopping bleeding. The study wi…

This study tests whether eating only during an 8-hour window each day (time-restricted eating) can help people with fatty liver disease (MASLD) lose weight and body fat. 150 adults will follow this eating pattern for 3 months, with some also limiting fruit and vegetable intake to…

This early-phase study will test whether a drug called Henggliejin can improve fatty liver in 149 adults with type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). Participants will take one tablet daily for 48 weeks. The main goal is to see if liver fibrosis risk scores …

This study tests whether diacerein, a drug made from a compound found in rhubarb, can help people with metabolic fatty liver disease. About 74 adults will receive either diacerein or a placebo for 24 weeks. The main goal is to see if the drug reduces fat in the liver, measured by…

This study tests whether empagliflozin (a diabetes drug) works better than statins for treating non-alcoholic fatty liver disease (NAFLD) and its more severe form, NASH. 400 obese, diabetic adults with NAFLD/NASH will take one of five drug combinations daily for 3 months. Researc…

This study tests whether adding a traditional Chinese medicine granule (Huazhi Rougan) to standard antibiotics can better treat both H. pylori infection and metabolic-associated fatty liver disease (MASH). About 286 adults with both conditions will receive either the herbal granu…

This study is testing whether a combination of simple, non-invasive tests—like a liver scan and blood samples—can accurately detect advanced liver fibrosis (scarring) in people at risk for fatty liver disease. Researchers will follow 1,200 adults aged 40 to 70 who have obesity, t…

This study tests whether an artificial intelligence (AI) program can analyze routine heart ultrasound images to find people who may have undiagnosed fatty liver disease or cirrhosis. About 2,000 adults will have their heart scans checked by the AI. If the AI flags them as high ri…

This study tests whether a combination of blood markers, ultrasound, and genetic information can accurately diagnose metabolic dysfunction-associated steatotic liver disease (MASLD) in children aged 8 to 18 with obesity. Each child provides a blood sample, undergoes a liver ultra…

This study tests a new wearable patch-type ultrasound probe that sticks to the skin over the liver to measure stiffness, which can indicate scarring (fibrosis) or cirrhosis. Researchers will compare its accuracy to the standard FibroScan device in 150 adults with chronic liver di…

This study looks at whether a common blood test called FIB-4 can accurately predict liver fibrosis (scarring) in people with obesity. Researchers will compare FIB-4 results with liver stiffness measurements from a specialized scan (FibroScan) in 400 obese patients. If the blood t…

This pilot study tests whether an AI tool called FibroX can help primary care providers better diagnose advanced liver fibrosis in people with MASLD, a common liver condition. Forty providers will review simulated patient cases, using either standard methods or FibroX, which give…

This study tests a near-infrared spectroscopy device that scans the liver with light to diagnose and measure fatty liver disease. Researchers aim to see if it can accurately detect fat levels above 5% and 30%, which are important for liver transplant decisions. The study will inc…

Researchers in South Savo, Finland, invite residents turning 45, 50 or 55 to take a blood test that measures many small molecules at once. The test estimates each person's 10-year risk of type 2 diabetes, heart attack, stroke, chronic kidney disease and fatty liver disease. Peopl…

This study tests whether a natural supplement called SAMe can help prevent liver cancer in people with advanced fatty liver disease (MASLD) and cirrhosis. About 94 adults will receive either SAMe or a placebo for 12 months. Researchers will measure changes in a blood test that pr…

This study looks at whether adding a mild electrical stimulation device (TENS) to a Mediterranean diet can help people with nonalcoholic fatty liver disease feel less hungry and improve their liver health. Fifty adults aged 35-45 with fatty liver will be split into two groups: on…

This study tests whether an 8-week home-based high-intensity interval training (HIIT) program, done on a stationary bike and supervised remotely, can reduce liver fat and improve other health measures in 54 adults aged 35-65 with metabolic dysfunction-associated fatty liver disea…

This study looks at how eating a high-fat or high-carb breakfast changes fat levels in the blood over 8 hours. Researchers will compare results among people with conditions like diabetes, fatty liver, or kidney disease, as well as healthy volunteers. Participants will have two ov…

Researchers at Assiut University are studying whether an underactive thyroid makes liver scarring worse in people with metabolic dysfunction-associated steatotic liver disease (MASLD). The trial enrolls 120 adults with MASLD, half of whom have overt or subclinical hypothyroidism …

This study looks at whether an underactive thyroid (hypothyroidism) is linked to more severe liver scarring in people with metabolic dysfunction-associated steatotic liver disease (MASLD). Researchers will compare two groups of adults with MASLD: those with hypothyroidism and tho…

This study tests new MRI techniques to measure blood flow and tissue details in the liver. Researchers will scan 110 people, including healthy volunteers and those with chronic liver disease or fibrosis, to see if these scans can reliably detect liver damage. The goal is to devel…

This study looks at anonymized health records from about 100,000 people in a Turkish hospital network to see how common cardiometabolic conditions—like obesity, type 2 diabetes, heart disease, fatty liver, and kidney disease—are and how often they occur together. By tracking thes…

This observational study looks at whether changes in liver stiffness, measured by a device called iLivTouch, can predict serious liver-related events and death in people with fatty liver disease that has progressed to advanced scarring. The study follows over 2,000 adults with th…

This study looks at whether a structured surveillance program using regular ultrasound and a blood test (alpha-fetoprotein) can detect liver cancer at an earlier, more treatable stage in people at high risk. About 300 adults with liver cirrhosis, chronic hepatitis B, or advanced …

This study looks at how bariatric surgery affects the liver's energy processing in people with obesity and fatty liver disease. Researchers will use safe, non-radioactive tracer infusions and MRI scans before, during, and six months after surgery to measure changes in liver metab…

This study looks at how common fatty liver disease (MASLD) is in adults with type 1 diabetes. Researchers will check 250 adults with type 1 diabetes for signs of liver fat and scarring, using non-invasive tests. The goal is to understand if type 1 diabetes raises the risk of live…

This study explores whether polycystic ovary syndrome (PCOS) independently contributes to fatty liver disease in adolescent girls, beyond the effects of obesity. Researchers will compare three groups of girls aged 10–18: those with PCOS and obesity, those with obesity alone, and …

This study investigates whether obstructive sleep apnea is linked to metabolic associated fatty liver disease (MAFLD) in adults. Researchers will measure sleep apnea severity using overnight sleep tests and liver fat using a special ultrasound-like scan. The goal is to see if wor…

This study looks at two types of liver disease — autoimmune hepatitis and non-alcoholic fatty liver disease — to see if fats in blood cells and tiny particles called extracellular vesicles differ between them. Researchers will collect blood samples from 24 adults and analyze thes…

This study follows 7,000 adults with type 2 diabetes and a common form of fatty liver disease (MASLD) to see how liver problems influence the risk of heart attacks, strokes, and heart failure. Researchers will track participants for five years, using advanced models to separate t…

This French study will collect medical data and biological samples from 800 people with autoimmune liver diseases. Researchers hope to identify new markers that explain why some patients respond well to treatment while others do not. The goal is to better understand the immune me…

This study will check if certain blood-based inflammation markers are linked to fatty liver disease (MASLD) in 100 adults. Participants will have their blood tested and their liver health assessed. The goal is to better understand the role of inflammation in this condition, not t…

This study looks at how HIV might change the way the body handles fats in the liver, leading to fatty liver disease. Researchers will collect one blood sample from 120 adults: people with HIV and fatty liver, people without HIV but with fatty liver, and healthy controls. By analy…

This study will compare meal timing habits between 400 participants, including new mothers and people with fatty liver disease, along with healthy controls. Participants will complete diet diaries and questionnaires, with some undergoing additional tests like blood sugar monitori…

This study will check how often muscle loss (sarcopenia) happens in 120 adults with metabolic fatty liver disease. Researchers will also see if muscle loss is linked to more severe liver scarring. The goal is to better understand the connection, not to test a new treatment.

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This study will check if a routine blood measure called mean platelet volume (MPV) can predict acute coronary syndrome (heart attack or unstable angina) in people with metabolic dysfunction-associated steatotic liver disease (MASLD). Researchers will compare MPV levels between 60…

This study follows 700 adults with fatty liver disease (MASLD) for three years to see if liver fat measured by ultrasound is linked to early heart problems. Participants get heart scans and checkups every 6 to 12 months. The goal is to find better ways to predict heart attacks, s…

This study tests whether two different ultrasound machines can accurately measure liver stiffness and inflammation in people with fatty liver disease. About 95 to 100 adults will take part, including healthy liver donors and patients with fatty liver. The goal is to see if these …

This study looks at whether certain blood test results (hs-CRP, triglycerides, and glucose) can help identify liver scarring in people with non-alcoholic fatty liver disease (NAFLD). Researchers will observe 96 adults who have NAFLD and check their blood markers alongside liver s…

This study will test a two-step screening program for advanced liver fibrosis in people with type 2 diabetes. About 1,714 patients will first get a blood test (FIB-4), and if that suggests risk, they will receive a liver stiffness measurement (transient elastography). The goal is…

This study will check how often fatty liver disease and liver scarring happen in adults with type 1 diabetes or LADA in Quebec. About 100 participants will get a special liver scan (FibroScan) during one visit. The goal is to find hidden liver problems that current checkups might…

This study looks at how a 12-week exercise program (strength and aerobic training twice a week) affects liver fat, inflammation, and scarring in people with metabolic fatty liver disease. It compares results between older adults (70+) and middle-aged adults (40-60), as well as be…

This study looks at 200 adults with fatty liver disease to find out how many are also obese. It will also describe the health details of patients who have fatty liver but are not overweight. The goal is to better understand the different types of fatty liver disease.

This study will examine whether a specific gut bacterium, Ruminococcus gnavus, and the chemicals it produces are linked to metabolic dysfunction-associated fatty liver disease (MAFLD). Researchers will compare 200 healthy adults and those with MAFLD to understand the connection. …

This study aims to create detailed computer models, or 'virtual twins,' of people with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). By analyzing data from over 7,700 adults, researchers hope to better understand how the disease progresses and predict who migh…

This study looks at how lowering insulin levels changes the way the liver makes sugar and fat. Researchers will give 36 overweight or obese adults with insulin resistance and fatty liver disease two different insulin infusions—one that keeps insulin high and one that lowers it by…

This study will test whether a special ultrasound technique can measure liver stiffness and fat as accurately as MRI in people with fatty liver disease. Researchers will compare results from both imaging methods in 145 healthy volunteers and patients. The goal is to find a simple…

This study will screen up to 10,000 adults aged 18-75 who are overweight or have metabolic issues like high blood sugar or cholesterol. Researchers will use questionnaires, blood tests, and liver ultrasounds to find out how common fatty liver disease is and what factors increase …

This study will check 200 adults with metabolic fatty liver disease for Helicobacter pylori infection using a stool test. The goal is to find out how common H. pylori is in this group. If a link is confirmed, it may open the door to new ways to manage fatty liver disease by treat…

This study follows 30 people with achalasia (a swallowing disorder) for one year after their treatment. Researchers want to see if the weight gain that often happens after treatment leads to worse metabolic health, like fatty liver or higher blood sugar. Participants will have bl…

This study looks at stored liver biopsy samples from 30 people with MASH (a fatty liver disease) to see if a protein test can predict who will develop liver cancer within 15 years. Half of the participants later got liver cancer, and half did not. Researchers will compare the pro…

This study will screen 200 adults with metabolic fatty liver disease (MAFLD) for high uric acid levels. Researchers will measure uric acid and liver function at diagnosis and after 6 months. The goal is to understand how common high uric acid is in these patients and whether it c…

This study looks at 100 adults who had their gallbladder removed at least 5 years ago to see if they are more likely to develop fatty liver disease (MAFLD). Researchers will check for fat in the liver and measure blood markers. The goal is to understand if gallbladder removal lea…

This study will compare a new handheld device to the standard iLivTouch system for measuring liver stiffness and fat in 224 adults with chronic liver disease. Participants will be tested with both devices while lying down and sitting. The goal is to see if the handheld device is …

This 10-year observational study will follow 10,000 adults with diabetes, metabolic disorders, and related conditions like high blood pressure and fatty liver disease. Researchers will collect routine medical data to identify markers of disease severity and activity. The goal is …

This study will track 100 liver transplant patients to see how many develop a new fatty liver condition called MASLD after their transplant. Researchers will also look for risk factors like weight, diabetes, and cholesterol levels. The goal is to better understand this common but…

This study will test whether ultrasound can measure liver fat as accurately as MRI in 30 adults with fatty liver disease. Participants will have both an ultrasound and an MRI scan. The goal is to see if ultrasound, which is cheaper and faster, could be a reliable alternative for …

This study will examine the connection between high uric acid levels (hyperuricemia) and non-alcoholic fatty liver disease (NAFLD) in 111 obese adults. Researchers will use blood tests, ultrasound, and FibroScan to measure uric acid, liver fat, and liver scarring. The goal is to …