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Could a palm vitamin e supplement help repair Alcohol-Damaged livers?

NCT ID NCT07466485

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase II trial tests whether a palm-derived form of vitamin E (tocotrienol) can improve liver health in adults with alcoholic fatty liver disease. 26 participants will take either the supplement or a placebo for six months, with regular blood tests and liver scans to track changes. The goal is to see if this natural supplement can reduce liver damage and support better liver function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
palm tocotrienol (a form of vitamin E)
What this could lead to
If it works, this could point toward a natural supplement to help manage alcoholic fatty liver disease and improve liver function.
What could go wrong
This is a small, early-phase trial with only 26 participants. Results may not apply to everyone, and the supplement may not show significant benefit over placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 26 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients with history of alcoholic use disorder with clinical and biochemical evidence of alcoholic steatohepatitis (AST:ALT \>2.0, elevated GGT) 2. Patients with Maddrey's discriminant function ≤ 32, and do not require the treatment of corticosteroid therapy or pentoxifylline. 3. Patients aged 18 to 65 4. Patients who could comply with alcohol abstinence. Exclusion Criteria: 1. Severe alcoholic hepatitis defined as Maddrey's discriminant function \>32 2. Patients with other concomitant liver diseases: 1. Hepatitis B 2. Hepatitis C 3. Non-alcoholic fatty liver disease (NAFLD) 4. Autoimmune hepatitis (AIH) 5. Hereditary hemochromatosis 3. Patients who are obese (a BMI of 30 kg/ m2 or more) and with metabolic syndromes 4. Patients with bleeding disorders and who have been on anticoagulant or antiaggregant treatments 5. Patients who have been on corticosteroid therapy or pentoxifylline for alcoholic hepatitis 6. Patients with hepatocellular carcinoma 7. Pregnant patients 8. Patients who are breastfeeding 9. Patients with Childs C liver cirrhosis 10. Patients who have pyridoxine allergy or history 11. Patients who are judged by investigator that participation of the study is difficult due to disease as follow; hepatic cirrhosis, Wilson's disease, malignant tumor, serious metabolic disease, severe renal disease, severe pulmonary disease, severe cardiovascular disease, severe nervous disease/psychiatric disorder, muscle disease and etc. 12. Patients taking vitamin E, herbal supplements, or other investigational products within 90 days prior to the participation in the study. 13. Patients who have been taken any medications that could affect the treatment: hypoglycemic agents, colchicine, penicillamine, corticosteroids, ursodeoxycholic acid, pentoxifylline, long-term use of NSAIDs, statins, neuroleptics, anticonvulsant medications, high-dose acetaminophen(\>=2.5g/day) 14. Patients who have received treatment that may affect liver function within 1 month prior to the participation in the study 15. Patients who could not comply with alcohol abstinence. 16. Patient who considered ineligible for participation in the study as Investigator's judgment

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hospital Canselor Tuanku Muhriz Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak

    Cheras, Kuala Lumpur, 56000, Malaysia

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