Digestive system disorder
MONDO:0004335A disease or disorder that involves the digestive system.
Also known as: digestive disease, digestive system disease, digestive system disease or disorder, digestive system disorder, disease of digestive system, disease or disorder of digestive system, disorder of digestive system, gastroenterological system disease
16300 clinical trials for this condition and its sub-types, 168 tagged with Digestive system disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Digestive system disorder
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Digestive system cancer 267 trials · 7,054 incl. sub-types
15 sub-types
- Digestive system carcinoma 25 trials · 4,876 incl. sub-types Sub-types →
- Intestinal cancer 25 trials · 2,786 incl. sub-types Sub-types →
- Liver cancer 254 trials · 1,700 incl. sub-types Sub-types →
- Malignant pancreatic neoplasm 899 trials · 1,444 incl. sub-types Sub-types →
- Gastric cancer 724 trials · 1,034 incl. sub-types Sub-types →
- Esophageal cancer 408 trials · 787 incl. sub-types Sub-types →
- Pharynx cancer 10 trials · 495 incl. sub-types Sub-types →
- Oral cavity cancer 42 trials · 288 incl. sub-types Sub-types →
- Gastroesophageal cancer 157 trials
- Gallbladder cancer 73 trials · 106 incl. sub-types Sub-types →
- Gastrointestinal lymphoma 0 trials · 7 incl. sub-types Sub-types →
- Jaw cancer 1 trial · 5 incl. sub-types Sub-types →
- Digestive system melanoma 0 trials · 2 incl. sub-types Sub-types →
- Malignant tumor of floor of mouth 0 trials · 2 incl. sub-types Sub-types →
- Spleen cancer 0 trials · 2 incl. sub-types Sub-types →
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Pancreas disorder 44 trials · 5,580 incl. sub-types
14 sub-types
- Endocrine pancreas disorder 1 trial · 3,923 incl. sub-types Sub-types →
- Pancreatic neoplasm 926 trials · 1,573 incl. sub-types Sub-types →
- Pancreatitis 120 trials · 203 incl. sub-types Sub-types →
- Exocrine pancreatic insufficiency 29 trials Sub-types →
- Recurrent acute pancreatitis 19 trials
- Accessory pancreas 0 trials
- Acinar cystic transformation of the pancreas 0 trials
- Annular pancreas 0 trials
- Congenital pancreatic cyst 0 trials
- Follicular cholangitis and pancreatitis 0 trials
- Lymphoepithelial cyst of the pancreas 0 trials
- Pancreatic mucinous ductal ectasia 0 trials
- Pancreatic steatorrhea 0 trials
- Pancreatic triacylglycerol lipase deficiency 0 trials Sub-types →
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Intestinal disorder 70 trials · 5,432 incl. sub-types
58 sub-types
- Large intestine disorder 2 trials · 3,811 incl. sub-types Sub-types →
- Intestinal neoplasm 4 trials · 3,074 incl. sub-types Sub-types →
- Inflammatory bowel disease 429 trials · 1,079 incl. sub-types Sub-types →
- Gastroenteritis 20 trials · 837 incl. sub-types Sub-types →
- Small intestine disorder 7 trials · 385 incl. sub-types Sub-types →
- Irritable bowel syndrome 221 trials
- Bowel dysfunction 11 trials · 210 incl. sub-types Sub-types →
- Glucose-galactose malabsorption 2 trials · 151 incl. sub-types Sub-types →
- Malabsorption syndrome 13 trials · 118 incl. sub-types Sub-types →
- Intestinal obstruction 44 trials · 91 incl. sub-types Sub-types →
- Eosinophilic gastrointestinal disease 9 trials · 73 incl. sub-types Sub-types →
- Intestinal fistula 6 trials · 63 incl. sub-types Sub-types →
- Necrotizing enterocolitis 51 trials Sub-types →
- Intestinal motility disease 10 trials · 39 incl. sub-types Sub-types →
- Short bowel syndrome 39 trials Sub-types →
- Diverticulitis 28 trials · 34 incl. sub-types Sub-types →
- Chronic intestinal failure 24 trials
- Neurogenic bowel 22 trials
- Postgastrectomy syndrome 2 trials · 20 incl. sub-types Sub-types →
- Hypertrophic pyloric stenosis 16 trials Sub-types →
- Parasitic intestinal disorder 0 trials · 16 incl. sub-types Sub-types →
- Ischemic bowel disorder 8 trials · 15 incl. sub-types Sub-types →
- Endometriosis of intestine 9 trials
- Intestinal perforation 9 trials Sub-types →
- Intestinal polyp 8 trials
- Protein-losing enteropathy 7 trials
- Intestinal atresia 3 trials · 6 incl. sub-types Sub-types →
- Chronic intestinal vascular insufficiency 4 trials
- Refractory celiac disease 4 trials
- Volvulus of midgut 4 trials Sub-types →
- Abetalipoproteinemia 2 trials
- Pneumatosis cystoides intestinalis 2 trials
- Angiodysplasia of intestine 1 trial
- Chronic enteropathy associated with SLCO2A1 gene 1 trial
- Cryptogenic multifocal ulcerous stenosing enteritis 1 trial
- Steatorrhea 1 trial Sub-types →
- 4-hydroxyphenylacetic aciduria 0 trials
- Aeromonas hydrophila intestinal disease 0 trials
- NK-cell enteropathy 0 trials
- Satoyoshi syndrome 0 trials
- Whipple disease 0 trials
- Aplasia cutis congenita-intestinal lymphangiectasia syndrome 0 trials
- Chronic atrial and intestinal dysrhythmia 0 trials
- Chronic diarrhea with villous atrophy 0 trials
- Collagenous sprue 0 trials
- Congenital diarrhea 7 with exudative enteropathy 0 trials
- Congenital enterocyte heparan sulfate deficiency 0 trials
- Cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder 0 trials
- Intestinal dysmotility syndrome 0 trials
- Intestinal lymphangiectasia 0 trials Sub-types →
- Intractable diarrhea-choanal atresia-eye anomalies syndrome 0 trials
- Isolated mesenteric vein thrombosis 0 trials
- Malakoplakia 0 trials
- Mucocele of appendix 0 trials
- Primary desmosis coli 0 trials
- Solitary rectal ulcer syndrome 0 trials
- Trichohepatoenteric syndrome 0 trials Sub-types →
- Visceral leiomyopathy, African degenerative 0 trials
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Hepatobiliary disorder 10 trials · 3,893 incl. sub-types
4 sub-types
- Liver disorder 323 trials · 3,604 incl. sub-types Sub-types →
- Hepatobiliary neoplasm 26 trials · 1,772 incl. sub-types Sub-types →
- Biliary tract disorder 22 trials · 1,001 incl. sub-types Sub-types →
- Gallbladder disorder 26 trials · 219 incl. sub-types Sub-types →
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Stomach disorder 4 trials · 1,623 incl. sub-types
19 sub-types
- Gastric neoplasm 685 trials · 1,101 incl. sub-types Sub-types →
- Gastroesophageal reflux disease 217 trials Sub-types →
- Functional gastric disease 47 trials · 213 incl. sub-types Sub-types →
- Gastritis 21 trials · 50 incl. sub-types Sub-types →
- Hiatus hernia 49 trials Sub-types →
- Pyloric stenosis 15 trials · 31 incl. sub-types Sub-types →
- Gastric intestinal metaplasia 18 trials
- Gastric ulcer 13 trials Sub-types →
- Stomach polyp 4 trials · 6 incl. sub-types Sub-types →
- Gastric dilatation 3 trials
- Achlorhydria 1 trial
- Pylorospasm 1 trial
- Dieulafoy lesion 0 trials
- Angiodysplasia of stomach 0 trials
- Cascade stomach 0 trials
- Gastric duplication 0 trials
- Non-hypoproteinemic hypertrophic gastropathy 0 trials
- Pyloric duplication 0 trials
- Stomach diverticulosis 0 trials
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Upper digestive tract disorder 6 trials · 1,226 incl. sub-types
2 sub-types
- Esophageal disorder 20 trials · 1,221 incl. sub-types Sub-types →
- Internal hirudiniasis 0 trials
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Autoimmune disorder of gastrointestinal tract 0 trials · 936 incl. sub-types
7 sub-types
- Type 1 diabetes mellitus 815 trials · 816 incl. sub-types Sub-types →
- Celiac disease 79 trials Sub-types →
- Autoimmune hepatitis 30 trials · 31 incl. sub-types Sub-types →
- Autoimmune enteropathy 2 trials · 11 incl. sub-types Sub-types →
- Autoimmune gastritis 3 trials
- Autoimmune pancreatitis 3 trials Sub-types →
- IgG4-related sclerosing cholangitis 0 trials
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Digestive system infectious disorder 4 trials · 605 incl. sub-types
22 sub-types
- Viral hepatitis 12 trials · 443 incl. sub-types Sub-types →
- Infectious colitis 0 trials · 69 incl. sub-types Sub-types →
- Intestinal infectious disease 3 trials · 49 incl. sub-types Sub-types →
- Small intestinal bacterial overgrowth 18 trials
- Parasitic intestinal disorder 0 trials · 16 incl. sub-types Sub-types →
- Liver abscess (disease) 4 trials
- Campylobacteriosis 3 trials Sub-types →
- Bacterial gastritis 2 trials
- Gastrointestinal tuberculosis 0 trials · 2 incl. sub-types Sub-types →
- Aeromonas hydrophila intestinal disease 0 trials
- Salmonella gastroenteritis 0 trials
- Whipple disease 0 trials
- Anal verrucous carcinoma 0 trials
- Bacterial esophagitis 0 trials
- Colorectal Kaposi sarcoma 0 trials Sub-types →
- Fungal esophagitis 0 trials Sub-types →
- Fungal gastritis 0 trials
- Internal hirudiniasis 0 trials
- Oropharyngeal anthrax 0 trials
- Polycystic echinococcosis 0 trials
- Viral esophagitis 0 trials
- Viral gastritis 0 trials Sub-types →
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Neoplasm of oropharynx 3 trials · 279 incl. sub-types
2 sub-types
- Oropharynx cancer 149 trials · 279 incl. sub-types Sub-types →
- Benign neoplasm of oropharynx 0 trials
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Digestive system neuroendocrine neoplasm 52 trials · 167 incl. sub-types
7 sub-types
- Digestive system neuroendocrine tumor, grade 1/2 66 trials · 145 incl. sub-types Sub-types →
- Pancreatic neuroendocrine neoplasm 9 trials · 85 incl. sub-types Sub-types →
- Intestinal neuroendocrine neoplasm 7 trials · 21 incl. sub-types Sub-types →
- Gastric neuroendocrine neoplasm 3 trials · 6 incl. sub-types Sub-types →
- Liver neuroendocrine carcinoma 3 trials Sub-types →
- Gallbladder neuroendocrine neoplasm 0 trials Sub-types →
- Salivary gland small cell carcinoma 0 trials
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Diarrheal disease 80 trials · 117 incl. sub-types
7 sub-types
- Acute diarrhea 10 trials · 42 incl. sub-types Sub-types →
- Inflammatory diarrhea 0 trials · 33 incl. sub-types Sub-types →
- Chronic diarrheal disease 10 trials Sub-types →
- Congenital diarrhea 0 trials · 5 incl. sub-types Sub-types →
- Secretory diarrhea 0 trials · 5 incl. sub-types Sub-types →
- Diarrheal disease secondary to altered bowel motility 0 trials Sub-types →
- Non-infectious diarrheal disease 0 trials Sub-types →
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Peptic ulcer disease 26 trials · 67 incl. sub-types
6 sub-types
- Peptic esophagitis 24 trials
- Gastric ulcer 13 trials Sub-types →
- Duodenal ulcer 7 trials
- Gastrojejunal ulcer 6 trials
- Active peptic ulcer disease 3 trials
- Peptic ulcer perforation 3 trials
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Gastrointestinal mucositis 3 trials · 52 incl. sub-types
2 sub-types
- Intestinal infectious disease 3 trials · 49 incl. sub-types Sub-types →
- Inflammatory diarrhea 0 trials · 33 incl. sub-types Sub-types →
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Benign digestive system neoplasm 0 trials · 41 incl. sub-types
10 sub-types
- Pleomorphic adenoma 12 trials
- Hepatobiliary benign neoplasm 2 trials · 8 incl. sub-types Sub-types →
- Benign neoplasm of pancreas 7 trials Sub-types →
- Intestinal benign neoplasm 1 trial · 7 incl. sub-types Sub-types →
- Benign neoplasm of esophagus 3 trials Sub-types →
- Benign neoplasm of stomach 1 trial · 2 incl. sub-types Sub-types →
- Hepatocellular adenoma 2 trials Sub-types →
- Benign neoplasm of gallbladder 0 trials Sub-types →
- Benign neoplasm of oropharynx 0 trials
- Bile duct papillary neoplasm 0 trials Sub-types →
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Hereditary mixed polyposis syndrome 5 trials · 6 incl. sub-types
2 sub-types
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Juvenile polyposis syndrome 5 trials
3 sub-types
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Gastrointestinal polyp 0 trials · 3 incl. sub-types
2 sub-types
- Gastrointestinal hamartoma 0 trials · 3 incl. sub-types Sub-types →
- Anal polyp 0 trials Sub-types →
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Cronkhite-Canada syndrome 1 trial
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Hyperplastic polyposis syndrome 1 trial
2 sub-types
- Colon serrated polyposis 1 trial
- Sessile serrated polyposis cancer syndrome 0 trials
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Meckel diverticulum 0 trials
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Caudal duplication 0 trials
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Common mesentery 0 trials
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Congenital peritoneal encapsulation 0 trials
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Digestive duplication 0 trials
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Diverticulosis, small-intestinal 0 trials
Most studied deeper sub-types
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New stapler aims to reduce leaks after colon surgery
Disease control Recruiting nowThis study is testing a new surgical stapler, called the Signia circular stapler, in people having left-sided colon, sigmoid, or rectal surgery. The goal is to see if it lowers the chance of a leak where the colon is reconnected. About 137 adults will take part, and the main focu…
Sponsor: Medtronic - MITG • Aim: Disease control
Last updated Sep 03, 2026 00:00 UTC
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Can robotic tools make stomach cancer surgery safer and faster?
Disease control Recruiting nowThis study looks at whether robotic-assisted surgery using a vessel sealer can improve outcomes for people with locally advanced stomach cancer. The vessel sealer is a tool that cuts and seals blood vessels with less heat damage than older devices. Researchers will track 300 pati…
Sponsor: The First Hospital of Jilin University • Aim: Disease control
Last updated Sep 02, 2026 00:00 UTC
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Real-world study tracks guselkumab's impact on IBD patients
Disease control Recruiting nowThis study will follow 500 people with Crohn's disease or ulcerative colitis who are starting guselkumab, a biologic drug. Researchers will measure how many achieve remission and how the treatment affects daily life, including fatigue and work productivity. The goal is to underst…
Sponsor: Janssen-Cilag G.m.b.H • Aim: Disease control
Last updated Aug 30, 2026 00:00 UTC
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New hope for colorectal cancer: experimental drug faces off against avastin
Disease control Recruiting nowThis Phase 3 trial is testing whether a new medicine called PF-08634404, combined with standard chemotherapy, works better than the current treatment Avastin plus chemo for people whose colorectal cancer has spread. About 800 participants who have not had prior treatment for meta…
Phase 3 • Sponsor: Pfizer • Aim: Disease control
Last updated Aug 19, 2026 00:00 UTC
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Could a weekly shot free short bowel patients from IV bags?
Disease control Recruiting nowThis phase 3 trial tests glepaglutide, a synthetic hormone given as a twice-weekly injection, in 90 adults with short bowel syndrome who rely on IV nutrition. The goal is to see if the drug can safely reduce the amount of IV support needed. Participants will be randomly assigned …
Phase 3 • Sponsor: Zealand Pharma • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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New drug combo aims to tame ulcerative colitis
Disease control Recruiting nowThis study tests two drugs, eltrekibart and mirikizumab, alone or together, in 140 adults with moderate-to-severe ulcerative colitis. The goal is to see if they can safely reduce inflammation and help patients achieve remission. Participants must have tried other treatments witho…
Phase 2 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Aug 01, 2026 00:00 UTC
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Poop pills for sick kids? early trial tests fecal transplants after transplant
Disease control Recruiting nowThis early-phase study tests whether fecal microbiota transplantation (FMT) is safe and feasible for children under 22 who have gut problems after a stem cell transplant. Ten participants will receive FMT via colonoscopy or a nasal tube. The main goal is to check for serious side…
Phase 1 • Sponsor: St. Jude Children's Research Hospital • Aim: Disease control
Last updated Jul 22, 2026 00:00 UTC
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Could a 4-Week radiation course be as good as 5 weeks for prostate cancer?
Disease control Recruiting nowThis study compares two radiotherapy schedules for men whose prostate cancer has returned after surgery. The standard treatment takes 5 weeks, while the shorter one takes 4 weeks. Researchers want to see if the shorter schedule causes no more side effects and controls the cancer …
Sponsor: CHU de Quebec-Universite Laval • Aim: Disease control
Last updated Jul 03, 2026 00:00 UTC
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Could a Plant-Based powder cut the need for IV nutrition?
Disease control Recruiting nowThis phase 2 trial tests crofelemer, a plant-based oral powder, in 18 adults with short bowel syndrome and intestinal failure who rely on IV nutrition. Participants receive either a low dose, a higher dose, or a placebo for 24 weeks. The goal is to see if crofelemer safely reduce…
Phase 2 • Sponsor: Napo Therapeutics, S.p.A. • Aim: Disease control
Last updated Jun 27, 2026 13:05 UTC
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New targeted drug shows promise for Hard-to-Treat cancers
Disease control Recruiting nowThis study tests a new drug called repotrectinib in people with advanced solid tumors that have certain gene changes (ALK, ROS1, or NTRK). The trial has two parts: first, finding a safe dose, and second, seeing how well the drug shrinks tumors. About 500 adults with advanced canc…
Phase 1/2 • Sponsor: Turning Point Therapeutics, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:38 UTC
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Can a daily supplement fix your gut? new study aims to find out
Disease control Recruiting nowThis 12-week study tests whether a synbiotic supplement (a mix of probiotics and prebiotics) can improve gut health in 40 adults with dysbiosis, an imbalance in gut bacteria. Participants take either the supplement or a placebo daily, and researchers measure changes in gut bacter…
Sponsor: OvationLab • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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Could a poop transplant ease autism symptoms?
Disease control Recruiting nowThis study tests whether fecal microbiota transplantation (FMT) can help children and young adults with autism who also have stomach issues. FMT involves transferring healthy donor stool into the patient's gut via colonoscopy. Researchers will track changes in gut and autism symp…
Phase 1/2 • Sponsor: Chang Gung Memorial Hospital • Aim: Disease control
Last updated Jun 27, 2026 11:03 UTC
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New liquid diet trial aims to help patients with severe bowel disorders
Disease control Recruiting nowThis study is testing an upgraded amino acid-based nutritional supplement for 30 children and adults who have severe gut problems like inflammatory bowel disease, short bowel syndrome, or severe allergies. Participants will use the supplement as part of their diet for 28 days. Re…
Sponsor: Nutricia UK Ltd • Aim: Disease control
Last updated Jun 27, 2026 09:06 UTC
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New nerve zap therapy could ease Kids' mysterious stomach and brain symptoms
Disease control Recruiting nowThis study tests a new way to treat children with gut-brain disorders like cyclic vomiting and functional dyspepsia. The therapy uses a mild electrical nerve stimulation to the ear, personalized based on each child's nerve activity. The goal is to improve quality of life and redu…
Sponsor: Medical College of Wisconsin • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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Heated chemo bath during stomach cancer surgery shows promise
Disease control Recruiting nowThis study looks at whether giving heated chemotherapy directly into the abdomen during surgery can help prevent stomach cancer from coming back. About 200 adults with advanced stomach cancer that has spread to the lining of the abdomen will receive the treatment. The goal is to …
Sponsor: Ukrainian Society of Clinical Oncology • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
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Stool test vs. colonoscopy: which is better for older adults with polyps?
Diagnosis Recruiting nowThis study compares two ways to monitor older adults (ages 65-82) who have had colon polyps in the past: an annual stool test (FIT) or a colonoscopy every few years. About 9,000 participants will be randomly assigned to one of the two methods and followed for up to 11 years to se…
Sponsor: Dartmouth-Hitchcock Medical Center • Aim: Diagnosis
Last updated Aug 15, 2026 00:00 UTC
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AI reads your gut scans to spot disease without a scope
Diagnosis Recruiting nowThis study is developing an artificial intelligence system that analyzes CT and MRI scans to diagnose and predict outcomes for digestive diseases like Crohn's disease, ulcerative colitis, and intestinal tuberculosis. Researchers are using data from 21 hospitals in China to train …
Sponsor: First Affiliated Hospital, Sun Yat-Sen University • Aim: Diagnosis
Last updated Jun 27, 2026 12:06 UTC
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C-Section babies get gut health boost in new probiotic trial
Prevention Recruiting nowThis study tests whether giving a daily probiotic supplement to 180 healthy full-term babies born by C-section can help them gain weight, reduce colic and spit-up, and improve their gut bacteria. The babies will receive either one of two probiotic blends or a placebo for the firs…
Sponsor: Anabio R&D • Aim: Prevention
Last updated Aug 15, 2026 00:00 UTC
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App-Based mind therapy tested for Kids' tummy troubles
Symptom relief Recruiting nowThis study tests whether a mobile app that plays guided imagery sessions can help reduce chronic abdominal pain in children aged 7 to 12. Participants listen to 10-15 minute audio sessions five days a week for eight weeks, alongside their usual care. The goal is to see if this ap…
Sponsor: Baylor College of Medicine • Aim: Symptom relief
Last updated Sep 19, 2026 00:00 UTC
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Probiotics may tame nausea from popular Weight-Loss shots
Symptom relief Recruiting nowThis study tests whether taking probiotics can reduce digestive side effects like nausea and diarrhea in people starting weight-loss drugs such as semaglutide or tirzepatide. Fifty adults with obesity will take either a probiotic capsule or a placebo daily for 26 weeks. The goal …
Sponsor: Hospices Civils de Lyon • Aim: Symptom relief
Last updated Aug 21, 2026 00:00 UTC
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No needles, no naps: new nose scope could transform gut checks for Weight-Loss patients
Symptom relief Recruiting nowThis study is testing a new, ultra-thin endoscope that goes through the nose without sedation, instead of the usual mouth-and-sedation approach. Researchers want to see if it improves patient experience and lowers costs for people in bariatric care. About 100 adults will try the …
Sponsor: Christopher C. Thompson, MD, MSc • Aim: Symptom relief
Last updated Jun 27, 2026 14:02 UTC
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Which diet soothes your gut best? new study tests FODMAP approaches
Symptom relief Recruiting nowThis study looks at how different FODMAP diets affect gut bacteria, gut barrier function, and symptoms in people with functional gastrointestinal disorders like IBS. About 60 adults will follow either a low FODMAP, gentle FODMAP, or standard dietary advice for two weeks. Research…
Sponsor: Universiti Kebangsaan Malaysia Medical Centre • Aim: Symptom relief
Last updated Jun 27, 2026 12:32 UTC
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Could a daily shake soothe Athletes' stomach troubles?
Symptom relief Recruiting nowThis study looks at whether a fermented whey protein and fiber supplement can improve digestive comfort in recreational athletes. Researchers will enroll 114 participants, some with and some without stomach complaints, and compare the supplement to a placebo. The goal is to see i…
Sponsor: Arizona State University • Aim: Symptom relief
Last updated Jun 27, 2026 12:31 UTC
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Diet or therapy? new study aims to find the best online treatment for IBS
Symptom relief Recruiting nowThis study compares two online treatments for Irritable Bowel Syndrome (IBS): a low-FODMAP diet program and exposure-based cognitive behavioral therapy (E-CBT). Researchers want to find out which treatment works best for different people and how they work. The study will include …
Sponsor: University of Melbourne • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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Could a common drug ease chronic stomach pain and nausea?
Symptom relief Recruiting nowThis study tests whether domperidone, a drug that helps the stomach empty food, can reduce symptoms like pain, bloating, nausea, and vomiting in people with chronic digestive disorders. About 200 patients who have not improved with standard treatments will take domperidone and re…
Phase 3 • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Jun 27, 2026 12:06 UTC
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Can a daily supplement soothe your gut? new study aims to find out
Symptom relief Recruiting nowThis 8-week study is testing a dietary supplement system called PhytoPower in 50 adults with digestive issues like bloating and discomfort. Participants take the supplement daily and provide stool samples to measure changes in gut health markers. The goal is to see if the supplem…
Sponsor: SF Research Institute, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 09:07 UTC
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Ear device could ease gut woes in kids with bendy joint disorder
Symptom relief Recruiting nowThis study is testing whether a small, battery-powered device worn on the ear can reduce gastrointestinal symptoms in children aged 10-18 with hypermobile Ehlers-Danlos syndrome (hEDS) and related autonomic nervous system problems. The device, called IB-Stim, delivers gentle elec…
Sponsor: Medical College of Wisconsin • Aim: Symptom relief
Last updated Jun 27, 2026 09:04 UTC
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Virtual reality could soothe mysterious chest pain
Symptom relief Recruiting nowThis study tests whether using virtual reality (VR) can reduce symptoms of non-cardiac chest pain, which is chest pain not caused by the heart. Ten adults with this condition will try VR sessions, and researchers will measure changes in pain, anxiety, and quality of life. The goa…
Sponsor: Mayo Clinic • Aim: Symptom relief
Last updated Jun 27, 2026 09:04 UTC
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Can a helping hand help elderly cancer patients finish chemo?
Symptom relief Recruiting nowThis study tests whether a special program of nutritional checks, medication review, and physical therapy can help people aged 75 and older complete their full course of chemotherapy for digestive cancer. About 144 participants will be randomly assigned to receive either the extr…
Sponsor: Centre Paul Strauss • Aim: Symptom relief
Last updated Jun 27, 2026 08:09 UTC
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Ear stimulation device aims to ease chemo side effects in ovarian cancer
Symptom relief Recruiting nowThis study tests whether a non-invasive device that gently stimulates a nerve in the ear can improve quality of life by reducing digestive symptoms like nausea and bloating during first-line chemotherapy for ovarian cancer. About 116 women will be randomly assigned to receive eit…
Phase 3 • Sponsor: Centre Francois Baclesse • Aim: Symptom relief
Last updated Jun 27, 2026 07:54 UTC
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Massive device registry aims to improve patient safety
Knowledge-focused Recruiting nowThis study is a registry that collects information on the safety and effectiveness of Medtronic medical devices already on the market. It will include up to 100,000 people who have or will receive a Medtronic product for conditions like heart, nerve, or digestive disorders. The g…
Sponsor: Medtronic • Aim: Knowledge-focused
Last updated Sep 20, 2026 00:00 UTC
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Can a Yogurt-Like drink boost your Gut's good bacteria?
Knowledge-focused Recruiting nowThis study investigates whether a fermented dairy product containing three specific Bifidobacterium strains can increase the diversity of gut bacteria in healthy adults aged 45 to 60. Participants consume either the test product or a regular yogurt twice daily for 28 days. Resear…
Sponsor: Danone Global Research & Innovation Center • Aim: Knowledge-focused
Last updated Aug 30, 2026 00:00 UTC
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Can we predict and treat cancer wasting better? a new study investigates
Knowledge-focused Recruiting nowThis study is looking at why some people with advanced cancer lose weight and muscle, a condition called cachexia. Researchers will follow 800 patients with advanced lung, pancreatic, or colorectal cancer to see if there are distinct subtypes of cachexia based on symptoms, biomar…
Sponsor: Kaiser Permanente • Aim: Knowledge-focused
Last updated Aug 22, 2026 00:00 UTC
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NIH launches massive GI data bank to fuel future discoveries
Knowledge-focused Recruiting nowThis study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) • Aim: Knowledge-focused
Last updated Aug 12, 2026 00:00 UTC
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Could disposable scopes replace reusable ones for routine stomach exams?
Knowledge-focused Recruiting nowThis trial asks whether single-use gastroscopes work as well as standard reusable ones for elective and subacute upper GI procedures. About 300 adults will be examined with either a disposable or a reusable scope, and endoscopists will rate performance on a questionnaire. The stu…
Sponsor: Zealand University Hospital • Aim: Knowledge-focused
Last updated Jul 30, 2026 00:00 UTC
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Poop power: what makes a perfect stool donor?
Knowledge-focused Recruiting nowThis trial investigates healthy volunteers who donate stool for fecal microbiota transplantation (FMT), a procedure used to treat certain gut disorders. Researchers aim to identify factors that lead to valid donations, such as donor health and lifestyle, to streamline the donatio…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jul 25, 2026 00:00 UTC
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Could a disposable scope at the bedside speed up stomach exams?
Knowledge-focused Recruiting nowThis study tests whether using a single-use gastroscope at the patient's bedside can shorten the time from when a doctor decides a stomach exam is needed to when it actually happens, compared to the usual reusable scopes in the endoscopy unit. The trial includes 180 adults admitt…
Sponsor: Zealand University Hospital • Aim: Knowledge-focused
Last updated Jul 18, 2026 00:00 UTC
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Scientists hunt for hidden clues to inflammatory bowel disease
Knowledge-focused Recruiting nowThis observational study compares inflammatory markers in the blood and tissue of people with active Crohn's disease or ulcerative colitis versus healthy volunteers. Researchers aim to identify differences in the IL-23/Th17 inflammatory pathway and other immune signals. The study…
Sponsor: University of Nottingham • Aim: Knowledge-focused
Last updated Jul 10, 2026 00:00 UTC
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Can stomach electricity reveal gut disease? new study investigates
Knowledge-focused Recruiting nowThis study uses a homemade device with electrodes placed on the belly to record electrical signals from the stomach and intestines. Researchers will compare these signals in healthy volunteers, people with Crohn's disease (with or without fibrosis), and people with functional gas…
Sponsor: Central Hospital, Nancy, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:02 UTC
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Scientists grow 'Mini-Guts' from patient biopsies to unlock secrets of Crohn's and colitis
Knowledge-focused Recruiting nowThis study collects small tissue samples (biopsies) from people undergoing routine endoscopy and grows them into mini-organs called organoids in the lab. These organoids mimic the real intestine and help researchers understand diseases like Crohn's and ulcerative colitis. The goa…
Sponsor: Rennes University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Are future surgeons ready for complex GI procedures? new survey investigates
Knowledge-focused Recruiting nowThis study uses an anonymous survey to understand who teaches advanced gastrointestinal (GI) surgery to fourth- and fifth-year general surgery residents in the U.S. It also measures residents' comfort with common and complex GI procedures and their interest in a specialized GI fe…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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Are surgery fellowships worth it? new study aims to find out
Knowledge-focused Recruiting nowThis study surveys current and past surgery fellows and their senior surgeons to see if advanced training in HPB (liver, pancreas, bile duct) and complex GI surgery prepares them for independent practice. About 100 participants will answer questions about their training and readi…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
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Can fixing reflux fix your esophagus? new study investigates
Knowledge-focused Recruiting nowThis study looks at whether weak esophageal contractions (ineffective motility) improve after partial fundoplication surgery for gastroesophageal reflux. Researchers will perform high-resolution manometry 18-24 months after surgery in 100 patients who had weak contractions before…
Sponsor: Prof Urs Zingg • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:04 UTC
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Mini-Livers could unlock secrets of liver cancer
Knowledge-focused Recruiting nowThis study creates miniature, lab-grown versions of liver cancer tumors from patient biopsies. Researchers will test how well different treatments work on these models and look at how gut health and the tumor's environment affect the disease. The goal is to better understand live…
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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Can a virtual health coach get more minorities into cancer trials?
Knowledge-focused Recruiting nowThis study is testing whether a website with a virtual community health educator can help Black and Hispanic cancer patients in Florida learn about and sign up for clinical trials. About 350 adults will be randomly assigned to either a standard information portal or one with a vi…
Sponsor: University of Florida • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:31 UTC
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New registry aims to unravel mysteries of chronic stomach conditions
Knowledge-focused Recruiting nowThis study is creating a registry of 250 people with symptoms of gastroparesis or functional dyspepsia, such as nausea, vomiting, and abdominal pain. Participants will fill out questionnaires, take a nutrient drink test, and have a gastric emptying scan. The goal is to collect da…
Sponsor: Johns Hopkins Bloomberg School of Public Health • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC
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New study tracks stomach paralysis in kids to uncover clues
Knowledge-focused Recruiting nowThis study is creating a national registry of 216 children, teens, and young adults (ages 8-25) with gastroparesis or similar symptoms. Researchers will track how symptoms like nausea and stomach pain change over 48 weeks using questionnaires and stomach-emptying tests. The goal …
Sponsor: Johns Hopkins Bloomberg School of Public Health • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC
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New survey aims to improve care for esophageal patients
Knowledge-focused Recruiting nowThis study is collecting survey responses from 1,000 people who have had or will have surgery on their esophagus. The goal is to validate new questionnaires that measure recovery and symptoms. The information will help doctors set expected recovery scores and improve treatment pl…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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New study aims to uncover hidden threat of enterovirus in newborns
Knowledge-focused Recruiting nowThis study is tracking enterovirus infections in newborns across Italy, with a special focus on a dangerous strain called Echovirus 11. Researchers will analyze samples from 1,600 babies in intensive care to understand how common these infections are, what makes some cases severe…
Sponsor: Fondazione IRCCS Policlinico San Matteo di Pavia • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC
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25-Year ERCP study aims to reduce pancreatitis risk
Knowledge-focused Recruiting nowThis study is a registry that collects information from patients who have had an ERCP, a procedure to examine the bile and pancreatic ducts. Researchers will look at data from 100 patients treated between 2000 and 2025 to understand what factors increase the risk of pancreatitis …
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Scientists hunt for biomarkers linking everyday toxins to allergies and illness
Knowledge-focused Recruiting nowThis study is collecting blood, urine, and breath samples from 280 adults—including those with metal allergies and healthy volunteers—to see if exposure to heavy metals and pollutants leaves distinct biological markers. Researchers will compare levels of metals, lung function, an…
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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Scientists investigate role of gut microbes in healing digestive leaks
Knowledge-focused Recruiting nowThis study looks at how bacteria in the gut (the microbiome) influence healing of leaks in the esophagus or stomach. Researchers will collect tissue and fluid samples from 50 adults during routine procedures to analyze microbial changes and the body's response. The goal is to und…
Sponsor: Baylor Research Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:07 UTC
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Can a simple tool improve swallowing care for cancer patients?
Knowledge-focused Recruiting nowThis study looks at how to get cancer clinics to use a standard tool called DIGEST to measure swallowing problems. Researchers will compare different training methods to see which works best. The goal is to improve how swallowing issues are tracked and managed in cancer care.
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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New stomach mapping device could unlock mysteries of Kids' tummy troubles
Knowledge-focused Recruiting nowThis observational study aims to understand stomach electrical activity in children aged 8-25 with digestive issues like slow stomach emptying or chronic pain. Researchers will use a non-invasive device (BSGM) to record stomach signals for up to 4 hours and compare them to health…
Sponsor: Children's Hospital of Philadelphia • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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Video tutorial may boost colonoscopy prep quality
Knowledge-focused Recruiting nowThis study compares two ways of explaining colonoscopy prep: a standard talk with the doctor versus watching a video tutorial at home. About 574 adults having their first colonoscopy will take part. The goal is to see if the video leads to better bowel cleanliness and helps docto…
Sponsor: Centre Hospitalier Saint Joseph Saint Luc de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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Are disposable scopes as good as reusable ones? new study investigates
Knowledge-focused Recruiting nowThis study looks at whether single-use gastroscopes work just as well as reusable ones when used in the operating room for upper stomach exams. About 700 adults will take part, and researchers will compare how often each scope successfully completes the procedure. The goal is to …
Sponsor: Zealand University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC