New stapler aims to reduce leaks after colon surgery
NCT ID NCT07351071
First seen Jan 20, 2026 · Last updated Jun 20, 2026 · Updated 17 times
Summary
This study is testing a new surgical stapler, called the Signia circular stapler, in people having left-sided colon, sigmoid, or rectal surgery. The goal is to see if it lowers the chance of a leak where the colon is reconnected. About 137 adults will take part, and the main focus is safety and how well the stapler works.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Duke University
RECRUITINGDurham, North Carolina, 27705, United States
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Lankenau Institute for Medical Research
RECRUITINGWynnewood, Pennsylvania, 19096, United States
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Massachusetts General Hospital
NOT_YET_RECRUITINGBoston, Massachusetts, 02114, United States
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Mayo Clinic
NOT_YET_RECRUITINGRochester, Minnesota, 55902, United States
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SSM Health St. Mary's Hospital - Madison
NOT_YET_RECRUITINGMadison, Wisconsin, 53715, United States
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The Ohio State University Wexner Medical Center
RECRUITINGColumbus, Ohio, 43210, United States
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The University of South Florida
RECRUITINGTampa, Florida, 33620, United States
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University of Texas Health Science Center at Houston
RECRUITINGHouston, Texas, 77030, United States
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Yale University
RECRUITINGNew Haven, Connecticut, 06520, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Signia circular stapler (a surgical device used to reconnect the colon after resection)
What this could lead to
If successful, this could show that the Signia stapler is safe and effective for left-sided colon surgery, potentially reducing the risk of anastomotic leaks.
What could go wrong
This is a single-arm, post-market study with no comparison group, so results may not prove superiority over other staplers. The main risk is still anastomotic leakage, which can be serious.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.