Anastomotic leak

This study is testing a new surgical stapler, called the Signia circular stapler, in people having left-sided colon, sigmoid, or rectal surgery. The goal is to see if it lowers the chance of a leak where the colon is reconnected. About 137 adults will take part, and the main focu…

This trial tests whether a modified transanal drainage tube can prevent anastomotic leakage—a serious complication where the new connection in the bowel leaks—after surgery for rectal cancer. About 968 adults with rectal adenocarcinoma will receive either the modified tube or sta…

This study is testing whether a procedure called gastric preconditioning—done before esophageal cancer surgery—can lower the risk of a serious complication called an anastomotic leak. The procedure uses a tiny tube to redirect blood flow in the stomach, which may help the surgica…

This study compares two surgical methods (Parks and Bacon) for ultra-low rectal cancer to see which one leads to better bowel function and quality of life a year after surgery. About 256 adults with rectal cancer will take part. The goal is to help doctors choose the best techniq…

This study looks at whether a specific dissolvable stitch (Monoplus) can lower the chance of a leak where the bowel is reconnected after colon cancer surgery. About 249 people having either keyhole or open surgery will take part. The main goal is to see if the leak rate within 30…

This study will follow 430 adults having colorectal surgery to understand why some develop a leak where the bowel is reconnected. Researchers will look at factors before, during, and after surgery. The goal is to create a way to predict and prevent this serious complication.

This study tests whether a quick, finger-prick blood test for C-reactive protein (CRP) can predict a serious complication called anastomotic leak after planned colorectal surgery. The goal is to catch leaks earlier, reduce the need for repeated blood draws, and help patients reco…