GASTROINTESTINAL DISEASES

This Phase 3 study tests a new medicine called PF-08634404 combined with chemotherapy for people whose colorectal cancer has spread. About 800 participants will be randomly assigned to receive either the new drug or the approved drug Avastin, both with chemo. The goal is to see i…

This study is testing whether fecal microbiota transplantation (FMT) can improve both gastrointestinal and autism-related symptoms in people aged 7 to 30 with autism and gut issues. Participants receive a colonoscopy to transplant healthy donor stool into their colon. The researc…

This study is testing a new surgical stapler, called the Signia circular stapler, in people having left-sided colon, sigmoid, or rectal surgery. The goal is to see if it lowers the chance of a leak where the colon is reconnected. About 137 adults will take part, and the main focu…

This study is the first time IDRX-42 is being tested in people. It aims to find out if the drug is safe and can shrink tumors in adults with advanced GIST that has spread or cannot be removed by surgery. Participants must have already tried the standard treatment imatinib without…

This study tests whether using virtual reality (VR) can reduce symptoms of non-cardiac chest pain, which is chest pain not caused by the heart. Ten adults with this condition will try VR sessions, and researchers will measure changes in pain, anxiety, and quality of life. The goa…

This study tests whether a daily supplement called Skål Pro (containing a friendly bacteria and a prebiotic fiber) can reduce belly pain, bloating, and irregular bowel movements in people with irritable bowel syndrome (IBS). About 60 adults with IBS will take either the supplemen…

This study looks at the bacteria and other microbes present in leaks that occur in the esophagus or stomach after surgery or injury. Researchers want to understand how these microbes change over time and how the body responds, with the goal of finding ways to help leaks heal fast…

This study is testing a new, ultra-thin endoscope that can be used without sedation to examine the upper digestive tract in people being treated for obesity. The goal is to see if this approach is more comfortable and convenient than traditional endoscopy, which usually requires …

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…