GASTROINTESTINAL DISEASES

This study tests a new medicine (PF-08634404) combined with standard chemotherapy against an approved drug (bevacizumab) plus chemotherapy for people with colorectal cancer that has spread. About 800 adults who have not had prior treatment for metastatic disease will be randomly …

This study tests a new drug, IDRX-42, for people with advanced gastrointestinal stromal tumors (GIST) that have spread or cannot be removed by surgery. The goal is to see if the drug is safe and can shrink or control these tumors. About 278 adults who have already tried the stand…

This study is testing whether transferring healthy gut bacteria (via fecal transplant) can improve both stomach issues and autism-related behaviors in 60 people aged 7-30 with autism and gastrointestinal problems. Researchers will measure changes in gut symptoms, social skills, a…

This study is testing a new surgical stapler (Signia circular stapler) in about 137 people having elective left-sided colon, sigmoid, or rectal surgery. The main goal is to see how often a serious complication called anastomotic leak (a leak where the bowel is reconnected) happen…

This study tests if using virtual reality (VR) can improve symptoms of non-cardiac chest pain — chest pain that isn't from a heart problem. Ten adults with this condition will try VR sessions, and researchers will measure changes in pain, anxiety, and quality of life using questi…

This study looks at the bacteria (microbiome) involved in leaks from the esophagus or stomach. Researchers want to understand how these germs change over time and how the body responds, so they can find better ways to help patients heal. About 50 adults with such leaks will provi…

This study is testing a new, ultra-thin endoscope that goes through the nose without sedation, making it easier and cheaper to examine the upper digestive tract in people with obesity. Researchers want to see if patients and doctors find it acceptable and comfortable. If successf…

This study collects medical information and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal disorders. The goal is to build a resource for future research to better understand and treat these diseases. Particip…