New drug combo aims to tame ulcerative colitis
NCT ID NCT06598943
First seen Jun 26, 2026 · Last updated Jul 31, 2026 · Updated 5 times
Summary
This study tests two drugs, eltrekibart and mirikizumab, alone or together, in 140 adults with moderate-to-severe ulcerative colitis. The goal is to see if they can safely reduce inflammation and help patients achieve remission. Participants must have tried other treatments without success.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- eltrekibart and mirikizumab
- What this could lead to
- If successful, this could provide a new treatment option for people with ulcerative colitis who haven't responded to other therapies.
- What could go wrong
- This is an early Phase 2 trial with only 140 participants, so results may not apply to everyone. The drugs may cause side effects or fail to improve symptoms.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 143 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Oct 2024
- Expected to finish
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Sep 2028
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Have had an established diagnosis of UC of ≥3 months in duration before baseline. * Have moderately to severely active UC as assessed by the UC disease activity score. * Have an inadequate response to, loss of response to, or intolerance to at least one conventional medication (including corticosteroids) or one advanced therapy (including biologics, Janus Kinase (JAK) inhibitors, or sphingosine-1-phosphate (S1P) immunomodulators). * Are on a stable dose of certain oral UC medications (including corticosteroids). * Must meet contraception requirements. Exclusion Criteria: * Have received anti-interleukin (IL)-23p19 or anti-IL-12p40 antibodies in the past. * Have experienced a thrombotic event within 24 weeks before baseline. * Have a current diagnosis of Crohn's Disease or certain other inflammatory gastrointestinal diseases. * Have had certain abdominal surgeries within the past 3 months or are likely to require surgery for UC during the study. * Have a history of certain adenomas, dysplasia's, or malignancies.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Ulcerative colitis are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
207 sites in 21 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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A.O.U. Citta' della Salute e della Scienza di Torino
RECRUITINGTorino, 10126, Italy
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A.O.U. Policlinico G. Martino
RECRUITINGGazzi - Messina, 98125, Italy
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AST Pesaro Urbino - Presidio Ospedaliero Santa Croce
RECRUITINGFano, 61032, Italy
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AZ Gastro Care - Chandler
NOT_YET_RECRUITINGChandler, Arizona, 85225, United States
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Advanced Research Institute - South Ogden
RECRUITINGOgden, Utah, 84405, United States
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AdventHealth Orlando
NOT_YET_RECRUITINGOrlando, Florida, 32803, United States
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Alexandra Hospital
RECRUITINGAthens, 11528, Greece
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Applied Research Center of Arkansas
RECRUITINGLittle Rock, Arkansas, 72205, United States
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Avicenna Clinical Research - SW Gastroenterology
RECRUITINGOak Lawn, Illinois, 60453-3754, United States
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Azienda Ospedale Università di Padova
RECRUITINGPadova, 35128, Italy
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Azienda Ospedaliera Universitaria Careggi
RECRUITINGFlorence, 50134, Italy
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Azienda Ospedaliero Universitaria
NOT_YET_RECRUITINGModena, 41124, Italy
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Baylor College of Medicine
RECRUITINGHouston, Texas, 77030, United States
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Beaumont Hospital, Dublin
RECRUITINGDublin, D9, Ireland
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Bispebjerg Hospital
NOT_YET_RECRUITINGKøbenhavn NV, 2400, Denmark
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Bugát Pál Kórház
NOT_YET_RECRUITINGGyöngyös, 3200, Hungary
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CEIM Hospital Universitario y Politecnico la Fe
RECRUITINGValencia, 46026, Spain
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CER Instituto Medico
NOT_YET_RECRUITINGQuilmes, B1878DVB, Argentina
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CHU De Grenoble Hopital Albert Michallon
RECRUITINGGrenoble, 38043, France
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CHU UCL Namur site Godinne
RECRUITINGYvoir, 5530, Belgium
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CHU de Nice Hopital de L'Archet
RECRUITINGNice, 06202, France
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CIPREC
RECRUITINGCABA, C1061AAS, Argentina
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CIUSSS de l'Est-de-l'Île-de-Montréal
NOT_YET_RECRUITINGMontreal, H1T 2M4, Canada
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Care Access-Ogden
RECRUITINGOgden, Utah, 84403, United States
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Centre Hospitalier Departemental (CHD) Vendee
RECRUITINGLa Roche-sur-Yon, 85925, France
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Centro Medico Privado de Reumatologia
RECRUITINGSAN M. de Tucuman, T4000AXL, Argentina
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Centro Medico Teknon - DIGESTIVO
RECRUITINGBarcelona, 8022, Spain
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Centro de Inmunología y Genética (CIGE)
NOT_YET_RECRUITINGMedellín, 5001000, Colombia
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Centrum Medyczne Kermed Renata Bojata-Bronisz i Ewa Kowalińska Sp.j.
RECRUITINGBydgoszcz, 85-231, Poland
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Centrum Medyczne Oporów
RECRUITINGWroclaw, 52-416, Poland
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Centrum Medyczne Plejady Magdalena Celińska-Löwenhoff, Michał Żołnowski sp.k
RECRUITINGKrakow, 30-363, Poland
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Centrum Nowoczesnych Terapii "Dobry Lekarz" sp. z o. o.
RECRUITINGKrakow, 31-011, Poland
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Charité Campus Virchow-Klinikum
RECRUITINGBerlin, 13353, Germany
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Chiba University Hospital
NOT_YET_RECRUITINGChiba, 260-8677, Japan
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Chu Tivoli
RECRUITINGLa Louvière, 7100, Belgium
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Chu de Rouen Hopital Charles Nicolle
RECRUITINGRouen, 76031, France
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Clinexpert Egészségügyi Szolgáltató és Kereskedelmi Kft
RECRUITINGBudapest, 1033, Hungary
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Clinexpert Gyöngyös Kft.
NOT_YET_RECRUITINGGyöngyös, 3200, Hungary
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Clinical Center " Dr Dragisa Misovic Dedinje"
RECRUITINGBelgrade, 11000, Serbia
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Clinical Center of Vojvodina
RECRUITINGNovi Sad, 21000, Serbia
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Clinical Hospital Center Bezanijska Kosa
RECRUITINGBelgrade, 11000, Serbia
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Clinical Hospital Center Zvezdara
RECRUITINGBelgrade, 11000, Serbia
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Clinical Hospital Centre Zemun
NOT_YET_RECRUITINGBelgrade, 11000, Serbia
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Clinical Trials Management Services, LLC
RECRUITINGThousand Oaks, California, 91360, United States
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Clinical Trials Management, LLC
NOT_YET_RECRUITINGMetairie, Louisiana, 70006, United States
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Clinnova Research
RECRUITINGOrange, California, 92868-4402, United States
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Clínica Privada Independencia
NOT_YET_RECRUITINGMunro, 1605, Argentina
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Colentina Clinical Hospital
RECRUITINGBucharest, 020125, Romania
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Comité de Ética en Investigación Biomédica IPS Centro Médico Julián Coronel
NOT_YET_RECRUITINGCali, 750035, Colombia
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DHR Health Gastroenterology - Edinburg
RECRUITINGEdinburg, Texas, 78539, United States
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Digestive Disease Consultants DDCJAX
NOT_YET_RECRUITINGOrange Park, Florida, 32073-4752, United States
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Digestive Disease Medicine of Central New York
RECRUITINGUtica, New York, 13502, United States
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Dr.Carol Davila Emergency University Central Military Hospital
NOT_YET_RECRUITINGBucharest, 010825, Romania
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Ege Universitesi Hastanesi
NOT_YET_RECRUITINGIzmir, 35100, Turkey (Türkiye)
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Ellipsis Research Group
RECRUITINGBrooklyn, New York, 11215, United States
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Emergency University Hospital
RECRUITINGBucharest, 50098, Romania
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Endoskopia Sp. z.o.o.
RECRUITINGSopot, 81-756, Poland
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Erick Alayo Medical Corp/Gastro SB Clinic
RECRUITINGChula Vista, California, 91910, United States
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Etická komise Krajské nemocnice T. Bati, a. s.
RECRUITINGZlín, 762 75, Czechia
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Etická komise Nemocnice Slaný
RECRUITINGSlaný, 27401, Czechia
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Fejér Megyei Szent György Egyetemi Oktató Kórház
RECRUITINGSzékesfehérvár, 8000, Hungary
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Florida Research Institute
NOT_YET_RECRUITINGLakewood Rch, Florida, 34211, United States
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Fondazione IRCCS Policlinico San Matteo
RECRUITINGPavia, 27100, Italy
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Fondazione Poliambulanza
NOT_YET_RECRUITINGBrescia, 25124, Italy
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Fukuoka University Chikushi Hospital
RECRUITINGChikushino-shi, 818-8502, Japan
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GCGA Physicians, LLC dba / Gastro Health Research
RECRUITINGCincinnati, Ohio, 45219, United States
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GCP Clinical Research, LLC
RECRUITINGTampa, Florida, 33609, United States
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Gastroenterology Associates of Western Michigan, P.L.C.
RECRUITINGWyoming, Michigan, 49519, United States
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Gastroenterology Research of San Antonio
RECRUITINGSan Antonio, Texas, 78229, United States
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Gastromed Sp. z o.o.
RECRUITINGTorun, 87-100, Poland
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Gazi University Medical Faculty Gazi Hospital
NOT_YET_RECRUITINGAnkara, 6560, Turkey (Türkiye)
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General Hospital "Djordje Joanovic"
RECRUITINGZrenjanin, 23000, Serbia
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General Hospital Dr Andjelko Visic Bjelovar
RECRUITINGBjelovar, 43000, Croatia
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General Hospital Dr. J. Bencevic
NOT_YET_RECRUITINGSlavonski Brod, 35 000, Croatia
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General Hospital Pancevo
RECRUITINGPančevo, 26101, Serbia
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General Hospital of Athens 'Evangelismos'
RECRUITINGAthens, 10676, Greece
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General Hospital of Athens Hippokratio
RECRUITINGAthens, 115 27, Greece
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General Oncology Hospital of Kifissia "Agioi Anargiroi"
NOT_YET_RECRUITINGNea Kifissia, 14564, Greece
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H-T. Centrum Medyczne-Endoterapia
NOT_YET_RECRUITINGTychy, 43-100, Poland
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HaFCED e.K. - Hamburgisches Forschungsinstitut für chronisch entzündliche Darmerkrankungen
NOT_YET_RECRUITINGHamburg, 20251, Germany
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Hachinohe City Hospital
NOT_YET_RECRUITINGHachinohe-shi, 031-8555, Japan
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Henri Mondor Hospital
RECRUITINGCréteil, 94010, France
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Hiroshima City North Medical Center Asa Citizens Hospital
RECRUITINGHiroshima, 731-0293, Japan
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Hiroshima University Hospital
NOT_YET_RECRUITINGHiroshima, 734-8551, Japan
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Hoshi General Hospital Foundation
NOT_YET_RECRUITINGKoriyama-shi, 963-8801, Japan
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Hospices Civils de Lyon - Centre Hospitalier Lyon Sud -
RECRUITINGPierre-Bénite, 69495, France
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Hospital Clínico Universitario de Santiago de Compostela
RECRUITINGSantiago de Compostela, 15706, Spain
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Hospital General Tomelloso
RECRUITINGCiudad Real, 13700, Spain
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Hospital Provincial del Centenario
RECRUITINGRosario, S2002KDS, Argentina
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Hospital Universitario Juan Ramon Jimenez
RECRUITINGHuelva, 21005, Spain
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Hospital Universitario La Paz
RECRUITINGMadrid, 28046, Spain
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Hospital Universitario Mayor Méderi
NOT_YET_RECRUITINGBogotá, 111411, Colombia
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Hospital Universitario Reina Sofia Comite Etico
RECRUITINGCórdoba, 14004, Spain
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Hospital Universitario Virgen Macarena
RECRUITINGSeville, 41009, Spain
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Hospital Universitario de Gran Canaria Doctor Negrín
RECRUITINGLas Palmas de GC, 35019, Spain
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Hyogo College of Medicine
RECRUITINGNishinomiya, 663-8501, Japan
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I.V.A.M. Clinical & Investigational Center, LLC
NOT_YET_RECRUITINGDoral, Florida, 33126, United States
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IRCCS - AOU di Bologna
RECRUITINGBologna, 40138, Italy
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IRCCS Ospedale Casa Sollievo della Sofferenza
RECRUITINGSan Giovanni Rotondo, 71013, Italy
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IRCCS Ospedale San Raffaele
RECRUITINGSegrate, 20132, Italy
-
IRCCS Policlinico San Donato
RECRUITINGSan Donato Milanese, 20097, Italy
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Infusion Clinic
RECRUITINGOsaka, 530-0011, Japan
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Inquest Clinical Research
RECRUITINGBaytown, Texas, 77521, United States
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Institutul Regional de Gastroenterologie și Hepatologie Prof. Dr. Octavian Fodor
RECRUITINGCluj-Napoca, 400162, Romania
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Interdisziplinäres Crohn Colitis Centrum Rhein-Main
NOT_YET_RECRUITINGFrankfurt am Main, 60594, Germany
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Intergrity Research
RECRUITINGHouston, Texas, 77043, United States
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International Center for Research LLC
RECRUITINGTampa, Florida, 33614, United States
-
Ip Clinic Sp. Z O. O.
RECRUITINGLodz, 90-752, Poland
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Isesaki Municipal Hospital
RECRUITINGIsesaki-shi, 372-0817, Japan
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Istituto Clinico Humanitas
RECRUITINGRozzano, 20089, Italy
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Iwate Medical University Hospital
RECRUITINGMorioka, 020-8505, Japan
-
JCHO Kyushu Hospital
NOT_YET_RECRUITINGKitakyushu-Shi, 806 8501, Japan
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JHCO Tokyo Yamate Medical Center
NOT_YET_RECRUITINGShinjuku-ku, 169-0073, Japan
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Kagoshima IBD Gastroenterology Clinic
RECRUITINGKagoshima, 892-0843, Japan
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Kitasato University Kitasato Institute Hospital
RECRUITINGMinatoku, 108 8642, Japan
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Klinikum Rechts der Isar der TU München
RECRUITINGMünchen, 81675, Germany
-
Kyorin University Hospital
RECRUITINGMitaka, 181-8611, Japan
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Liepaja Regional Hospital
RECRUITINGLiepāja, LV-3414, Latvia
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London Digestive Disease Institute
NOT_YET_RECRUITINGLondon, N6K 1M6, Canada
-
London Health Sciences Centre
RECRUITINGLondon, N6A 5W9, Canada
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MVZ für spezialärztliche Versorgung Dr. Friedrichs GmbH
RECRUITINGDuisburg, 47055, Germany
-
Magen-Darm-Zentrum Remscheid
RECRUITINGRemscheid, 42859, Germany
-
ManerMed Sp z o.o. Centrum Medyczne ,Medis
RECRUITINGBydgoszcz, 85-229, Poland
-
Matsushima Hospital
NOT_YET_RECRUITINGYokohama, 220 0041, Japan
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Mautalen Salud e Investigacion-Centro de Osteopatías Médicas
RECRUITINGCiudad Autonoma de Buenos Air, C1128AAF, Argentina
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Med-GASTR SP. Z O.O., SP.K.
RECRUITINGLodz, 91 034, Poland
-
Medical Research Center of Connecticut, LLC
RECRUITINGHamden, Connecticut, 06518-3602, United States
-
Medizinische Hochschule Hannover
RECRUITINGHanover, 30625, Germany
-
Medrise Sp. z o.o
RECRUITINGLublin, 20-582, Poland
-
Melita Medical
RECRUITINGWroclaw, 53-611, Poland
-
Mersin University Medical Faculty Hospital
NOT_YET_RECRUITINGMersin, 33169, Turkey (Türkiye)
-
Mie University Hospital
RECRUITINGTsu, 514-8507, Japan
-
Military Medical Academy
RECRUITINGBelgrade, 11000, Serbia
-
Montreal General Hospital
NOT_YET_RECRUITINGMontreal, H3G 1A4, Canada
-
NTT Medical Center Tokyo
NOT_YET_RECRUITINGShinagawa-KU, 141-8625, Japan
-
NZOZ FOR MED sp. z o.o.
RECRUITINGWadowice, 34-100, Poland
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Nara Prefecture General Medical Center
RECRUITINGNara, 630-8054, Japan
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National Hospital Organization Hirosaki General Medical Center
NOT_YET_RECRUITINGHirosaki, 036-8545, Japan
-
National Hospital Organization Kanazawa Medical Center
NOT_YET_RECRUITINGKanazawa, 920-8650, Japan
-
National Hospital Organization Shizuoka Medical Center
RECRUITINGSunto-gun, 411-8611, Japan
-
NexGen Research
RECRUITINGLima, Ohio, 45801, United States
-
Nodal Medical Center
RECRUITINGTampa, Florida, 33607, United States
-
Northwestern University
NOT_YET_RECRUITINGChicago, Illinois, 60611, United States
-
Novum Research, LLC
NOT_YET_RECRUITINGClermont, Florida, 34711, United States
-
Oita Red Cross Hospital
NOT_YET_RECRUITINGŌita, 870-0033, Japan
-
Om Research LLC
RECRUITINGVictorville, California, 92395, United States
-
Om Research, LLC
RECRUITINGLancaster, California, 93534, United States
-
Orlando Health Digestive Health Institute
RECRUITINGOrlando, Florida, 32803-1248, United States
-
Ospedale S. Paolo
RECRUITINGMilan, 20142, Italy
-
Ospedale Sandro Pertini
NOT_YET_RECRUITINGRoma, 157, Italy
-
Our Lady of the Snow St. Mary's Hospital
NOT_YET_RECRUITINGKurume-shi, 830 8543, Japan
-
PAGNI-University General Hospital of Heraklion
RECRUITINGHeraklion, 71500, Greece
-
Pauls Stradins Clinical Univeristy Hospital
RECRUITINGRiga, LV-1002, Latvia
-
Peak Gastroenterology Associates
RECRUITINGColorado Springs, Colorado, 80907-6262, United States
-
Pioneer Clinical Research NY
RECRUITINGNew York, New York, 10012-3645, United States
-
Policlinico Tor Vergata
RECRUITINGRoma, 00133, Italy
-
Policlinico Universitario Campus Bio-Medico
RECRUITINGRome, 00128, Italy
-
Poliklinika Borzan
RECRUITINGOsijek, 31000, Croatia
-
Poliklinika Solmed
RECRUITINGZagreb, 10000, Croatia
-
Preferred Research Partners
NOT_YET_RECRUITINGLittle Rock, Arkansas, 72211, United States
-
Prospective Research Innovations
RECRUITINGRancho Cucamonga, California, 91730-4850, United States
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Research Bay,Inc.
RECRUITINGTampa, Florida, 33607, United States
-
Reserka
NOT_YET_RECRUITINGMiami, Florida, 33176, United States
-
S.C Centrul de Gastroenterologie Dr. Goldis S.R.L
RECRUITINGTimișoara, 300002, Romania
-
S.C. Centrul Medical Medicum SRL
RECRUITINGBucharest, 012015, Romania
-
SC Farmacia AO Ordine Mauriziano
RECRUITINGTorino, 10128, Italy
-
Saiseikai Fukuoka General Hospital
NOT_YET_RECRUITINGFukuoak, 810-0001, Japan
-
Sapporo Higashi Tokushukai Hospital
RECRUITINGSapporo, 065-0033, Japan
-
Sapporo IBD Clinic
RECRUITINGSapporo Shi Chuo Ku, 064-0919, Japan
-
Semmelweis University
RECRUITINGBudapest, 1088, Hungary
-
Showa University Koto Toyosu Hospital
NOT_YET_RECRUITINGKōtoku, 135 8577, Japan
-
Smart Medical Research - Jackson Heights
RECRUITINGJackson Heights, New York, 11372, United States
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Sotiria Thoracic Diseases Hospital of Athens
RECRUITINGAthens, 11527, Greece
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Southern California GI and Liver Centers (SCLC)
RECRUITINGCoronado, California, 92118, United States
-
Special Hospital Medico
RECRUITINGRijeka, 51000, Croatia
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Studiengesellschaft BSF Unternehmergesellschaft
RECRUITINGHalle, 06108, Germany
-
SurGal clinic s.r.o.
NOT_YET_RECRUITINGBrno, 60200, Czechia
-
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ
NOT_YET_RECRUITINGSzeged, 6725, Hungary
-
Tokai University Hospital
RECRUITINGIsehara, 259-1193, Japan
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Tokushukai Sapporo Tokushukai Hospital
RECRUITINGSapporo, 40041, Japan
-
Tokyo Metro Bokutoh Hospital
NOT_YET_RECRUITINGSumida-ku, 130-8575, Japan
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Topolowa Medicenter Ryszawa & Wspólnicy Sp.j.
RECRUITINGKrakow, 31-506, Poland
-
Toyama University Hospital
RECRUITINGToyama, 930-0194, Japan
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Tsujinaka Hospital Kashiwanoha
RECRUITINGKashiwa, 277-0871, Japan
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Twoja Przychodnia Opolskie Centrum Medyczne
RECRUITINGOpole, 45 819, Poland
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Twoja Przychodnia Pcm
RECRUITINGPoznan, 60-324, Poland
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Tyler Research Institute
RECRUITINGTyler, Texas, 75701, United States
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United Medical Doctors
RECRUITINGLos Alamitos, California, 90720-3433, United States
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University Hospital Center Zagreb
NOT_YET_RECRUITINGZagreb, 10000, Croatia
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University Hospital of Ioannina
RECRUITINGIoannina, 45500, Greece
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University of North Carolina
RECRUITINGChapel Hill, North Carolina, 27599, United States
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University of Washington School Medicine
NOT_YET_RECRUITINGSeattle, Washington, 98195, United States
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Università di Cagliari - Presidio Policlinico Monserrato
RECRUITINGMonserrato, 09042, Italy
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Universitätsklinikum Augsburg, III. Medizinische Klinik Studienzentrum
RECRUITINGAugsburg, 86156, Germany
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Universitätsklinikum Brandenburg GmbH
RECRUITINGBrandenburg an der Havel, 14770, Germany
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Universitätsklinikum Frankfurt Goethe-Universität, Medizinische Klinik 1
RECRUITINGFrankfurt am Main, 60590, Germany
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Universitätsklinikum Schleswig-Holstein
RECRUITINGKiel, 24105, Germany
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Universitätsklinikum Ulm
NOT_YET_RECRUITINGUlm, 89081, Germany
-
VISTAMED
RECRUITINGWroclaw, 53-149, Poland
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Valahia Medical Center SRL
RECRUITINGPloieşti, 100032, Romania
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Valley View Research
RECRUITINGGarden Grove, California, 92845, United States
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Vojenska nemocnice Brno p.o.
RECRUITINGBrno, 615 00, Czechia
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WIP Warsaw IBD Point Profesor Kierkus
RECRUITINGWarsaw, 04-501, Poland
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Well Pharma Medical Research Corp.
RECRUITINGMiami, Florida, 33173, United States
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Yamanashi Prefectural Central Hospital
NOT_YET_RECRUITINGKofu, 400-8506, Japan
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Óbudai Egészségügyi Centrum
RECRUITINGBudapest, 1036, Hungary
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İnönü Üniversitesi Tıp Fakültesi
NOT_YET_RECRUITINGMalatya, 44280, Turkey (Türkiye)
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